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Aliases for MIR4539 Gene

Subcategory (RNA class) for MIR4539 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4539 Gene

  • MicroRNA 4539 2 3 5
  • Hsa-Mir-4539 3

External Ids for MIR4539 Gene

Previous GeneCards Identifiers for MIR4539 Gene

  • GC14U901284
  • GC14M107726
  • GC14M105926
  • GC14M105985
  • GC14M105998
  • GC14M106077
  • GC14M106175
  • GC14M106270
  • GC14M108070

Summaries for MIR4539 Gene

Entrez Gene Summary for MIR4539 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4539 Gene

MIR4539 (MicroRNA 4539) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4539 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4539 Gene

Genomics for MIR4539 Gene

GeneHancer (GH) Regulatory Elements for MIR4539 Gene

Promoters and enhancers for MIR4539 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I105857 Enhancer 0.8 ENCODE dbSUPER 550.8 +1.5 1541 0.2 PKNOX1 ZNF687 EBF1 MNT POLR2A IKZF1 ATF7 IKZF2 IGHM MIR4539 IGHD
GH14I105855 Enhancer 0.6 ENCODE dbSUPER 550.8 +1.9 1941 0.2 ZNF687 POLR2A BACH1 MIR4539 IGHM IGHD
GH14I105858 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 0.8 -2.9 -2882 8.6 PKNOX1 SMAD1 NFIB BMI1 BATF KLF5 IRF4 ATF7 ETV6 BCLAF1 MIR4537 ENSG00000225200 ENSG00000257270 CDCA4 MTA1 TEX22 IGHJ3 IGHJ3P IGHJ4 IGHJ5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4539 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4539 Gene

Genomic Locations for MIR4539 Gene
chr14:105,857,513-105,857,572
(GRCh38/hg38)
Size:
60 bases
Orientation:
Minus strand
chr14:106,323,682-106,323,741
(GRCh37/hg19)

Genomic View for MIR4539 Gene

Genes around MIR4539 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4539 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4539 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4539 Gene

Proteins for MIR4539 Gene

Post-translational modifications for MIR4539 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4539 Gene

Domains & Families for MIR4539 Gene

Gene Families for MIR4539 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4539: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4539 Gene

Function for MIR4539 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4539 Gene

Localization for MIR4539 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4539 Gene

Pathways & Interactions for MIR4539 Gene

SuperPathways for MIR4539 Gene

No Data Available

Interacting Proteins for MIR4539 Gene

Gene Ontology (GO) - Biological Process for MIR4539 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4539 Gene

Drugs & Compounds for MIR4539 Gene

No Compound Related Data Available

Transcripts for MIR4539 Gene

mRNA/cDNA for MIR4539 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4539 Gene

No ASD Table

Relevant External Links for MIR4539 Gene

GeneLoc Exon Structure for
MIR4539
ECgene alternative splicing isoforms for
MIR4539

Expression for MIR4539 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4539 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4539 Gene:

MIR4539
genes like me logo Genes that share expression patterns with MIR4539: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4539 Gene

Orthologs for MIR4539 Gene

Evolution for MIR4539 Gene

ENSEMBL:
Gene Tree for MIR4539 (if available)
TreeFam:
Gene Tree for MIR4539 (if available)

No data available for Orthologs for MIR4539 Gene

Paralogs for MIR4539 Gene

No data available for Paralogs for MIR4539 Gene

Variants for MIR4539 Gene

Sequence variations from dbSNP and Humsavar for MIR4539 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs111174256 -- 105,858,270(-) C/A upstream_transcript_variant
rs111207013 -- 105,857,847(-) G/A upstream_transcript_variant
rs111207015 -- 105,858,237(-) A/C upstream_transcript_variant
rs111207016 -- 105,858,667(-) T/C upstream_transcript_variant
rs11160884 -- 105,859,111(-) C/T upstream_transcript_variant

Additional Variant Information for MIR4539 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4539

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR4539 Gene

Disorders for MIR4539 Gene

Additional Disease Information for MIR4539

No disorders were found for MIR4539 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4539 Gene

Publications for MIR4539 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 58
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4539 Gene

Sources for MIR4539 Gene

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