microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4531 Gene

Subcategory (RNA class) for MIR4531 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR4531 Gene

  • MicroRNA 4531 2 3 5
  • Hsa-Mir-4531 2 3
  • MIR4531 2 5
  • MIMAT0019070 50
  • MI0016898 50

External Ids for MIR4531 Gene

Previous GeneCards Identifiers for MIR4531 Gene

  • GC19U901538
  • GC19M045157

Summaries for MIR4531 Gene

Entrez Gene Summary for MIR4531 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4531 Gene

MIR4531 (MicroRNA 4531) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4531 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4531 Gene

Genomics for MIR4531 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4531 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J044653 Enhancer 0.9 Ensembl ENCODE 600.7 -0.6 -560 1.5 CTCF BACH1 JUND MTA2 ZNF143 PKNOX1 REST RAD21 TCF12 TRIM22 MIR4531 PVR CEACAM19 LOC107985305 ENSG00000266903
GH19J044657 Enhancer 0.9 Ensembl ENCODE 0.7 -3.7 -3730 0.8 HNRNPL CTCF ZNF143 RBFOX2 PKNOX1 RXRB REST RAD21 POLR2A TRIM22 PVR CEACAM19 MIR4531 LOC107985305 ENSG00000266903
GH19J044647 Enhancer 0.9 Ensembl ENCODE dbSUPER 0.7 +5.0 4966 3.2 RBFOX2 SP1 SCRT2 ZSCAN29 HNF4A RXRA ZNF664 REST HNF4G PVR CEACAM19 CEACAM22P MIR4531 ENSG00000266903 LOC107985305
GH19J044648 Promoter/Enhancer 0.7 Ensembl dbSUPER 0.4 +6.8 6832 0.2 ZBTB33 MAFK PVR MIR4531 CEACAM19 ENSG00000266903 LOC107985305
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4531 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4531 Gene

Genomic Locations for MIR4531 Gene
chr19:44,653,686-44,653,732
(GRCh38/hg38)
Size:
47 bases
Orientation:
Minus strand
chr19:45,156,956-45,157,002
(GRCh37/hg19)
Size:
47 bases
Orientation:
Minus strand

Genomic View for MIR4531 Gene

Genes around MIR4531 on UCSC Golden Path with GeneCards custom track
MIR4531 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4531 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4531 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4531 Gene

Proteins for MIR4531 Gene

Post-translational modifications for MIR4531 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4531 Gene

Domains & Families for MIR4531 Gene

Gene Families for MIR4531 Gene

HGNC:
genes like me logo Genes that share domains with MIR4531: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4531 Gene

Function for MIR4531 Gene

Phenotypes From GWAS Catalog for MIR4531 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4531 Gene

Localization for MIR4531 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4531 Gene

Pathways & Interactions for MIR4531 Gene

PathCards logo

SuperPathways for MIR4531 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4531 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4531 Gene

Drugs & Compounds for MIR4531 Gene

No Compound Related Data Available

Transcripts for MIR4531 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4531 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000759ABE_9606 precursor_RNA 47 4

HGNC: 41872,

RefSeq: NR_039756,

Ensembl: ENST00000636960 (view in UCSC) ,

miRBase: MI0016898,

URS0000034450_9606 miRNA 17 2

RefSeq: NR_039756,

miRBase: MIMAT0019070,

MIR4531 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4531 Gene

No ASD Table

Relevant External Links for MIR4531 Gene

GeneLoc Exon Structure for
MIR4531

No data available for mRNA/cDNA for MIR4531 Gene

Expression for MIR4531 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4531 Gene

Orthologs for MIR4531 Gene

Evolution for MIR4531 Gene

ENSEMBL:
Gene Tree for MIR4531 (if available)
TreeFam:
Gene Tree for MIR4531 (if available)

No data available for Orthologs for MIR4531 Gene

Paralogs for MIR4531 Gene

No data available for Paralogs for MIR4531 Gene

Variants for MIR4531 Gene

Additional dbSNP identifiers (rs#s) for MIR4531 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4531 Gene

Variant ID Type Subtype PubMed ID
nsv1062812 CNV gain 25217958
nsv483005 CNV loss 15286789

Additional Variant Information for MIR4531 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4531

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4531 Gene

Disorders for MIR4531 Gene

Additional Disease Information for MIR4531

No disorders were found for MIR4531 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4531 Gene

Publications for MIR4531 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4531 Gene

Sources for MIR4531 Gene