microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4525 Gene

Subcategory (RNA class) for MIR4525 Gene

miRNA

Number of RNA Genes sources:

4 / 14

Aliases for MIR4525 Gene

  • MicroRNA 4525 2 3 5
  • Hsa-MiR-4525 166 177
  • Hsa-Mir-4525 3
  • MIMAT0019064 51
  • MI0016892 51
  • MIR4525 2

External Ids for MIR4525 Gene

Previous GeneCards Identifiers for MIR4525 Gene

  • GC17U901644
  • GC17M080628

Summaries for MIR4525 Gene

Entrez Gene Summary for MIR4525 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4525 Gene

MIR4525 (MicroRNA 4525) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4525 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4525 Gene

Genomics for MIR4525 Gene

GeneHancer (GH) Regulatory Elements for MIR4525 Gene

Promoters and enhancers for MIR4525 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J082668 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 -0.4 -366 1.1 CTCF POLR2G GABPA REST ZBTB25 TGIF2 RAD21 TEAD1 SMC3 ZSCAN9 MIR4525 WDR45B FN3K ENSG00000263063 ENSG00000262147 ENSG00000261888 lnc-FOXK2-2 lnc-WDR45B-6 RAB40B
GH17J082669 Enhancer 0.5 ENCODE dbSUPER 500.7 -1.7 -1720 1 NR2F2 RXRA MIR4525 lnc-FOXK2-2 WDR45B FN3K ENSG00000263063 FN3KRP ENSG00000262663 RAB40B lnc-WDR45B-6
GH17J082664 Enhancer 0.8 Ensembl CraniofacialAtlas dbSUPER 0.7 +3.5 3544 0.9 NRF1 ZNF423 TAF15 KLF1 MAZ RBM39 RFX1 FN3K ENSG00000262147 WDR45B MIR4525 lnc-WDR45B-3 RAB40B lnc-WDR45B-6
GH17J082661 Enhancer 0.3 dbSUPER 0.4 +6.2 6152 0.9 ZNF263 FN3K WDR45B ENSG00000262147 MIR4525 lnc-WDR45B-3 lnc-WDR45B-6 RAB40B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4525 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4525 Gene

Genomic Locations for MIR4525 Gene
chr17:82,668,233-82,668,307
(GRCh38/hg38)
Size:
75 bases
Orientation:
Minus strand
chr17:80,626,109-80,626,183
(GRCh37/hg19)
Size:
75 bases
Orientation:
Minus strand

Genomic View for MIR4525 Gene

Genes around MIR4525 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4525 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4525 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4525 Gene

Proteins for MIR4525 Gene

Post-translational modifications for MIR4525 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4525 Gene

Domains & Families for MIR4525 Gene

Gene Families for MIR4525 Gene

HGNC:
genes like me logo Genes that share domains with MIR4525: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4525 Gene

Function for MIR4525 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4525 Gene

Localization for MIR4525 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR4525 gene
Compartment Confidence
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4525 Gene

Pathways & Interactions for MIR4525 Gene

PathCards logo

SuperPathways for MIR4525 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR4525 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4525 Gene

Drugs & Compounds for MIR4525 Gene

No Compound Related Data Available

Transcripts for MIR4525 Gene

mRNA/cDNA for MIR4525 Gene

2 RNACentral transcripts :
1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 miRBase transcripts :
3 ENA transcripts :
1 LncBase transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4525 Gene

No ASD Table

Relevant External Links for MIR4525 Gene

GeneLoc Exon Structure for
MIR4525

Expression for MIR4525 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4525 Gene

Orthologs for MIR4525 Gene

Evolution for MIR4525 Gene

ENSEMBL:
Gene Tree for MIR4525 (if available)
TreeFam:
Gene Tree for MIR4525 (if available)

No data available for Orthologs for MIR4525 Gene

Paralogs for MIR4525 Gene

No data available for Paralogs for MIR4525 Gene

Variants for MIR4525 Gene

Additional dbSNP identifiers (rs#s) for MIR4525 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4525 Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
esv2762577 CNV gain+loss 21179565
nsv1062980 CNV gain 25217958
nsv1067362 CNV gain 25217958
nsv1067553 CNV loss 25217958
nsv428351 CNV gain 18775914
nsv509680 CNV insertion 20534489
nsv833575 CNV loss 17160897
nsv952395 CNV deletion 24416366

Additional Variant Information for MIR4525 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4525

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4525 Gene

Disorders for MIR4525 Gene

Additional Disease Information for MIR4525

No disorders were found for MIR4525 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4525 Gene

Publications for MIR4525 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 54
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54

Products for MIR4525 Gene

Sources for MIR4525 Gene