microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4520-2 Gene

Subcategory (RNA class) for MIR4520-2 Gene

miRNA

Number of RNA Genes sources:

2 / 14

Aliases for MIR4520-2 Gene

  • MicroRNA 4520-2 2 3 5
  • MicroRNA 4520b 2 3
  • Hsa-Mir-4520-2 3
  • Hsa-Mir-4520b 3
  • MIMAT0020300 51
  • MIMAT0019235 51
  • Mir-4520-2 3
  • MI0017358 51
  • MIR4520-2 2
  • MIR4520B 3

External Ids for MIR4520-2 Gene

Previous HGNC Symbols for MIR4520-2 Gene

  • MIR4520B

Summaries for MIR4520-2 Gene

Entrez Gene Summary for MIR4520-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4520-2 Gene

MIR4520-2 (MicroRNA 4520-2) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4520-2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4520-2 Gene

Genomics for MIR4520-2 Gene

GeneHancer (GH) Regulatory Elements for MIR4520-2 Gene

Promoters and enhancers for MIR4520-2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J006654 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 500.7 +0.7 652 3.8 ZBTB40 CTCF ZIC2 GABPA ZBTB26 RFX1 POLR2A ZNF341 SP2 ZBTB17 ENSG00000261996 ALOX15P1 MIR4520-1 MIR4520-2 lnc-TXNDC17-1 KIAA0753 TNK1 C17orf100
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4520-2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4520-2 Gene

Genomic Locations for MIR4520-2 Gene
chr17:6,655,449-6,655,502
(GRCh38/hg38)
Size:
54 bases
Orientation:
Plus strand

Genomic View for MIR4520-2 Gene

Genes around MIR4520-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4520-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4520-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4520-2 Gene

Proteins for MIR4520-2 Gene

Post-translational modifications for MIR4520-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4520-2 Gene

Domains & Families for MIR4520-2 Gene

Gene Families for MIR4520-2 Gene

HGNC:
genes like me logo Genes that share domains with MIR4520-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4520-2 Gene

Function for MIR4520-2 Gene

Phenotypes From GWAS Catalog for MIR4520-2 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4520-2 Gene

Localization for MIR4520-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4520-2 Gene

Pathways & Interactions for MIR4520-2 Gene

PathCards logo

SuperPathways for MIR4520-2 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR4520-2 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4520-2 Gene

Drugs & Compounds for MIR4520-2 Gene

No Compound Related Data Available

Transcripts for MIR4520-2 Gene

mRNA/cDNA for MIR4520-2 Gene

3 RNACentral transcripts :
2 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
8 ENA transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4520-2 Gene

No ASD Table

Relevant External Links for MIR4520-2 Gene

GeneLoc Exon Structure for
MIR4520-2

Expression for MIR4520-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4520-2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR4520-2

genes like me logo Genes that share expression patterns with MIR4520-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4520-2 Gene

Orthologs for MIR4520-2 Gene

Evolution for MIR4520-2 Gene

ENSEMBL:
Gene Tree for MIR4520-2 (if available)
TreeFam:
Gene Tree for MIR4520-2 (if available)

No data available for Orthologs for MIR4520-2 Gene

Paralogs for MIR4520-2 Gene

No data available for Paralogs for MIR4520-2 Gene

Variants for MIR4520-2 Gene

Additional dbSNP identifiers (rs#s) for MIR4520-2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4520-2 Gene

Variant ID Type Subtype PubMed ID
nsv574278 CNV gain 21841781

Additional Variant Information for MIR4520-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4520-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4520-2 Gene

Disorders for MIR4520-2 Gene

Additional Disease Information for MIR4520-2

No disorders were found for MIR4520-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4520-2 Gene

Publications for MIR4520-2 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 54
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3 54
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54

Products for MIR4520-2 Gene

Sources for MIR4520-2 Gene