microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR451A Gene

Subcategory (RNA class) for MIR451A Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR451A Gene

  • MicroRNA 451a 2 3 5
  • Hsa-Mir-451 2 3 178
  • MicroRNA 451 2 3
  • Hsa-MiR-451a 163 173
  • MIR451A 2 5
  • Hsa-Mir-451a 3
  • MIMAT0001631 50
  • MI0001729 50
  • Mir-451a 3
  • MIRN451 3
  • RF00722 168
  • MIR451 3

External Ids for MIR451A Gene

Previous HGNC Symbols for MIR451A Gene

  • MIRN451
  • MIR451

Previous GeneCards Identifiers for MIR451A Gene

  • GC17M027190
  • GC17M027194
  • GC17M027268

Summaries for MIR451A Gene

Entrez Gene Summary for MIR451A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR451A Gene

MIR451A (MicroRNA 451a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR451A include Glioma Susceptibility 1 and Gastric Cancer. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR451A Gene

Additional gene information for MIR451A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR451A Gene

Genomics for MIR451A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR451A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J028861 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 600.7 -0.9 -912 1.9 LEF1 IKZF1 JUND MTA2 MTA1 NR2C1 HDAC1 TARDBP CBX3 UBTF ENSG00000264066 MIR144 MIR451A MIR451B MIR4732 lnc-ERAL1-1 FLOT2 DHRS13 KIAA0100 PROCA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR451A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR451A Gene

Genomic Locations for MIR451A Gene
chr17:28,861,369-28,861,440
(GRCh38/hg38)
Size:
72 bases
Orientation:
Minus strand
chr17:27,188,090-27,188,984
(GRCh37/hg19)
Size:
895 bases
Orientation:
Minus strand

Genomic View for MIR451A Gene

Genes around MIR451A on UCSC Golden Path with GeneCards custom track
MIR451A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR451A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR451A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR451A Gene

Proteins for MIR451A Gene

Post-translational modifications for MIR451A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR451A Gene

Domains & Families for MIR451A Gene

Gene Families for MIR451A Gene

genes like me logo Genes that share domains with MIR451A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR451A Gene

Function for MIR451A Gene

Phenotypes From GWAS Catalog for MIR451A Gene

Animal Model Products

CRISPR Products

miRNA for MIR451A Gene

miRTarBase miRNAs that target MIR451A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR451A Gene

Localization for MIR451A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR451A gene
Compartment Confidence
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR451A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 20159880
GO:0070062 extracellular exosome IDA 28159509
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR451A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR451A Gene

Pathways & Interactions for MIR451A Gene

PathCards logo

SuperPathways for MIR451A Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR451A: view

Pathways by source for MIR451A Gene

1 KEGG pathway for MIR451A Gene

Gene Ontology (GO) - Biological Process for MIR451A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 negative regulation of gene expression IDA 20816946
GO:0030336 negative regulation of cell migration IDA 20816946
GO:0035195 gene silencing by miRNA IEA --
GO:0035470 positive regulation of vascular wound healing IDA 25006399
GO:0043065 positive regulation of apoptotic process IDA 20816946
genes like me logo Genes that share ontologies with MIR451A: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR451A Gene

Drugs & Compounds for MIR451A Gene

No Compound Related Data Available

Transcripts for MIR451A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR451A Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000068196F_9606 precursor_RNA 72 6

HGNC: 32053,

RefSeq: NR_029970,

Ensembl: ENST00000385059 (view in UCSC) ,

miRBase: MI0001729,

Rfam: RF00722,

ENA: LM609031.1:1..72:precursor_RNA,

URS00002E857A_9606 miRNA 22 5

RefSeq: NR_029970,

LncBase: hsa-miR-451a,

miRBase: MIMAT0001631,

TarBase: hsa-miR-451a,

ENA: LM379535.1:1..22:ncRNA, LM609031.1:17..38:ncRNA,

URS0000EFE3FD_9606 precursor_RNA 43 1

MirGeneDB: Hsa-Mir-451,

URS00002AB26F_9606 miRNA 23 1

MirGeneDB: Hsa-Mir-451_5p,

URS00000ED3D8_9606 miRNA 21 1

ENA: AY940875.1:1..21:ncRNA,

MIR451A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR451A Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR451A Gene

No ASD Table

Relevant External Links for MIR451A Gene

GeneLoc Exon Structure for
MIR451A

Expression for MIR451A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR451A

Evidence on tissue expression from TISSUES for MIR451A Gene

  • Blood(2.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR451A Gene

Orthologs for MIR451A Gene

Evolution for MIR451A Gene

ENSEMBL:
Gene Tree for MIR451A (if available)
TreeFam:
Gene Tree for MIR451A (if available)

No data available for Orthologs for MIR451A Gene

Paralogs for MIR451A Gene

No data available for Paralogs for MIR451A Gene

Variants for MIR451A Gene

Additional dbSNP identifiers (rs#s) for MIR451A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR451A Gene

Variant ID Type Subtype PubMed ID
esv3640315 CNV loss 21293372

Additional Variant Information for MIR451A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR451A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR451A Gene

Disorders for MIR451A Gene

MalaCards: The human disease database

(13) MalaCards diseases for MIR451A Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
glioma susceptibility 1
  • glm1
gastric cancer
  • gastric cancer, somatic
colorectal cancer
  • crc
breast cancer
  • breast lobular carcinoma
pulmonary hypertension
  • primary pulmonary hypertension
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR451A

genes like me logo Genes that share disorders with MIR451A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR451A Gene

Publications for MIR451A Gene

  1. Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zeta. (PMID: 20679397) Patrick DM … Olson EN (Genes & development 2010) 2 3
  2. microRNA-451a prevents activation of matrix metalloproteinases 2 and 9 in human cardiomyocytes during pathological stress stimulation. (PMID: 31618079) Scrimgeour NR … Høydal MA (American journal of physiology. Cell physiology 2020) 3
  3. The CAV1 Gene 3' Untranslated Region Single Nucleotide Polymorphisms Are Associated with the Risk of Pulmonary Hypertension in Chinese Han Chronic Obstructive Pulmonary Patients. (PMID: 31386584) Li M … Dong L (Genetic testing and molecular biomarkers 2019) 3
  4. E2F7, EREG, miR-451a and miR-106b-5p are associated with the cervical cancer development. (PMID: 30607582) Zong S … Yue Y (Archives of gynecology and obstetrics 2019) 3
  5. Exosomal miR-451a Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting LPIN1. (PMID: 31162914) Zhao S … Yang S (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2019) 3

Products for MIR451A Gene

Sources for MIR451A Gene