microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4519 Gene

Subcategory (RNA class) for MIR4519 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR4519 Gene

  • MicroRNA 4519 2 3 5
  • Hsa-Mir-4519 2 3
  • MIR4519 2 5
  • MIMAT0019056 50
  • MI0016885 50

External Ids for MIR4519 Gene

Previous GeneCards Identifiers for MIR4519 Gene

  • GC16U901343
  • GC16P030886

Summaries for MIR4519 Gene

Entrez Gene Summary for MIR4519 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4519 Gene

MIR4519 (MicroRNA 4519) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4519 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4519 Gene

Genomics for MIR4519 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4519 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J030872 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 600.7 +0.4 438 5.3 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 TFE3 LEF1 IKZF1 NFKBIZ MIR762HG MIR4519 RNF40 SETD1A BCL7C SRCAP TAOK2 KAT8 ENSG00000260267 NPIPB13
GH16J030881 Enhancer 0.8 Ensembl ENCODE 0.4 -7.0 -6978 2.6 ZNF692 RFX1 ZIC2 ZNF600 ZNF341 SCRT2 BMI1 ZNF189 SPI1 ZNF384 CCDC189 SNORA30 SRCAP MIR4519 MIR762HG ENSG00000262721 BCL7C MIR762 ZNF629
GH16J030893 Promoter/Enhancer 0.6 Ensembl dbSUPER 0.4 -17.2 -17178 0.2 ZNF600 MIR762 ZNF629 BCL7C ENSG00000262721 MIR4519 MIR762HG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4519 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4519 Gene

Genomic Locations for MIR4519 Gene
chr16:30,875,266-30,875,323
(GRCh38/hg38)
Size:
58 bases
Orientation:
Minus strand
chr16:30,886,587-30,886,644
(GRCh37/hg19)
Size:
58 bases
Orientation:
Minus strand

Genomic View for MIR4519 Gene

Genes around MIR4519 on UCSC Golden Path with GeneCards custom track
MIR4519 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4519 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4519 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4519 Gene

Proteins for MIR4519 Gene

Post-translational modifications for MIR4519 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4519 Gene

Domains & Families for MIR4519 Gene

Gene Families for MIR4519 Gene

HGNC:
genes like me logo Genes that share domains with MIR4519: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4519 Gene

Function for MIR4519 Gene

Phenotypes From GWAS Catalog for MIR4519 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4519 Gene

Localization for MIR4519 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4519 Gene

Pathways & Interactions for MIR4519 Gene

PathCards logo

SuperPathways for MIR4519 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4519 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4519 Gene

Drugs & Compounds for MIR4519 Gene

No Compound Related Data Available

Transcripts for MIR4519 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4519 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075A0A9_9606 precursor_RNA 58 4

HGNC: 41544,

RefSeq: NR_039744,

Ensembl: ENST00000579767 (view in UCSC) ,

miRBase: MI0016885,

URS000075DD24_9606 miRNA 18 2

RefSeq: NR_039744,

miRBase: MIMAT0019056,

MIR4519 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4519 Gene

No ASD Table

Relevant External Links for MIR4519 Gene

GeneLoc Exon Structure for
MIR4519

No data available for mRNA/cDNA for MIR4519 Gene

Expression for MIR4519 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4519 Gene

Orthologs for MIR4519 Gene

Evolution for MIR4519 Gene

ENSEMBL:
Gene Tree for MIR4519 (if available)
TreeFam:
Gene Tree for MIR4519 (if available)

No data available for Orthologs for MIR4519 Gene

Paralogs for MIR4519 Gene

No data available for Paralogs for MIR4519 Gene

Variants for MIR4519 Gene

Additional dbSNP identifiers (rs#s) for MIR4519 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4519 Gene

Variant ID Type Subtype PubMed ID
dgv35n68 CNV loss 17160897
nsv833189 CNV loss 17160897

Additional Variant Information for MIR4519 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4519

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4519 Gene

Disorders for MIR4519 Gene

No disorders were found for MIR4519 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4519 Gene

Publications for MIR4519 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4519 Gene

Sources for MIR4519 Gene