microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4518 Gene

Subcategory (RNA class) for MIR4518 Gene

miRNA

Number of RNA Genes sources:

4 / 17

Aliases for MIR4518 Gene

  • MicroRNA 4518 2 3 5
  • Hsa-Mir-4518 2 3
  • Hsa-MiR-4518 163 173
  • MIR4518 2 5
  • MIMAT0019055 50
  • MI0016884 50
  • Mir-4518 3

External Ids for MIR4518 Gene

Previous GeneCards Identifiers for MIR4518 Gene

  • GC16U901347

Summaries for MIR4518 Gene

Entrez Gene Summary for MIR4518 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4518 Gene

MIR4518 (MicroRNA 4518) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4518 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4518 Gene

Genomics for MIR4518 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4518 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J030521 Enhancer 1.2 Ensembl ENCODE dbSUPER 0.4 +18.7 18682 2 GATAD2A ATF7 PRDM10 TFE3 NFKBIZ GABPA PKNOX1 RXRB IRF2 SP1 hsa-miR-5095-194 piR-43284 ENSG00000235560 ZNF768 MIR4518 ITGAL
GH16J030509 Enhancer 0.8 Ensembl ENCODE dbSUPER 0.4 +6.2 6180 1.8 ZNF7 ZSCAN29 KDM1A ZMYM3 ZNF121 ENSG00000235560 MIR4518 hsa-miR-5095-194 ZNF768 ITGAL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4518 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4518 Gene

Genomic Locations for MIR4518 Gene
chr16:30,503,919-30,504,001
(GRCh38/hg38)
Size:
83 bases
Orientation:
Plus strand
chr16:30,515,240-30,515,322
(GRCh37/hg19)
Size:
83 bases
Orientation:
Plus strand

Genomic View for MIR4518 Gene

Genes around MIR4518 on UCSC Golden Path with GeneCards custom track
MIR4518 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4518 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4518 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4518 Gene

Proteins for MIR4518 Gene

Post-translational modifications for MIR4518 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4518 Gene

Domains & Families for MIR4518 Gene

Gene Families for MIR4518 Gene

HGNC:
genes like me logo Genes that share domains with MIR4518: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4518 Gene

Function for MIR4518 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4518 Gene

Localization for MIR4518 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4518 Gene

Pathways & Interactions for MIR4518 Gene

PathCards logo

SuperPathways for MIR4518 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4518 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4518 Gene

Drugs & Compounds for MIR4518 Gene

No Compound Related Data Available

Transcripts for MIR4518 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4518 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000759B50_9606 precursor_RNA 83 5

HGNC: 41809,

RefSeq: NR_039743,

Ensembl: ENST00000580665 (view in UCSC) ,

miRBase: MI0016884,

ENA: LM611344.1:1..83:precursor_RNA,

URS00004DEA91_9606 miRNA 26 5

RefSeq: NR_039743,

LncBase: hsa-miR-4518,

miRBase: MIMAT0019055,

TarBase: hsa-miR-4518,

ENA: LM382435.1:1..26:ncRNA, LM611344.1:50..75:ncRNA,

MIR4518 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR4518 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4518 Gene

No ASD Table

Relevant External Links for MIR4518 Gene

GeneLoc Exon Structure for
MIR4518

Expression for MIR4518 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4518 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR4518

genes like me logo Genes that share expression patterns with MIR4518: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4518 Gene

Orthologs for MIR4518 Gene

Evolution for MIR4518 Gene

ENSEMBL:
Gene Tree for MIR4518 (if available)
TreeFam:
Gene Tree for MIR4518 (if available)

No data available for Orthologs for MIR4518 Gene

Paralogs for MIR4518 Gene

No data available for Paralogs for MIR4518 Gene

Variants for MIR4518 Gene

Additional dbSNP identifiers (rs#s) for MIR4518 Gene

Additional Variant Information for MIR4518 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4518

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR4518 Gene

Disorders for MIR4518 Gene

No disorders were found for MIR4518 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4518 Gene

Publications for MIR4518 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4518 Gene

Sources for MIR4518 Gene