microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4517 Gene

Subcategory (RNA class) for MIR4517 Gene

miRNA

Number of RNA Genes sources:

4 / 17

Aliases for MIR4517 Gene

  • MicroRNA 4517 2 3 5
  • Hsa-Mir-4517 2 3
  • Hsa-MiR-4517 163 173
  • MIR4517 2 5
  • MIMAT0019054 50
  • MI0016883 50
  • Mir-4517 3

External Ids for MIR4517 Gene

Previous GeneCards Identifiers for MIR4517 Gene

  • GC16U901341
  • GC16P028971
  • GC16P028963

Summaries for MIR4517 Gene

Entrez Gene Summary for MIR4517 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4517 Gene

MIR4517 (MicroRNA 4517) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4517 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4517 Gene

Genomics for MIR4517 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4517 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J028950 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 0.4 -7.1 -7142 2.7 SP1 HNRNPL CREB1 GATAD2A TEAD4 PRDM10 ZNF629 RFX1 SIX5 IKZF1 NFATC2IP EIF3C SULT1A2 SMG1P2 SGF29 EIF3CL KCTD13 TMEM219 MIR4517 SPNS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4517 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4517 Gene

Genomic Locations for MIR4517 Gene
chr16:28,958,583-28,958,661
(GRCh38/hg38)
Size:
79 bases
Orientation:
Plus strand
chr16:28,969,904-28,969,982
(GRCh37/hg19)
Size:
79 bases
Orientation:
Plus strand

Genomic View for MIR4517 Gene

Genes around MIR4517 on UCSC Golden Path with GeneCards custom track
MIR4517 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4517 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4517 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4517 Gene

Proteins for MIR4517 Gene

Post-translational modifications for MIR4517 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4517 Gene

Domains & Families for MIR4517 Gene

Gene Families for MIR4517 Gene

HGNC:
genes like me logo Genes that share domains with MIR4517: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4517 Gene

Function for MIR4517 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4517 Gene

Localization for MIR4517 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR4517 gene
Compartment Confidence
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4517 Gene

Pathways & Interactions for MIR4517 Gene

PathCards logo

SuperPathways for MIR4517 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4517 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4517 Gene

Drugs & Compounds for MIR4517 Gene

No Compound Related Data Available

Transcripts for MIR4517 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4517 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075EBD5_9606 precursor_RNA 79 5

HGNC: 41878,

RefSeq: NR_039742,

Ensembl: ENST00000578855 (view in UCSC) ,

miRBase: MI0016883,

ENA: LM611343.1:1..79:precursor_RNA,

URS00003FA24D_9606 miRNA 25 5

RefSeq: NR_039742,

LncBase: hsa-miR-4517,

miRBase: MIMAT0019054,

TarBase: hsa-miR-4517,

ENA: LM382434.1:1..25:ncRNA, LM611343.1:5..29:ncRNA,

MIR4517 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR4517 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4517 Gene

No ASD Table

Relevant External Links for MIR4517 Gene

GeneLoc Exon Structure for
MIR4517

Expression for MIR4517 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4517 Gene

genes like me logo Genes that share expression patterns with MIR4517: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4517 Gene

Orthologs for MIR4517 Gene

Evolution for MIR4517 Gene

ENSEMBL:
Gene Tree for MIR4517 (if available)
TreeFam:
Gene Tree for MIR4517 (if available)

No data available for Orthologs for MIR4517 Gene

Paralogs for MIR4517 Gene

No data available for Paralogs for MIR4517 Gene

Variants for MIR4517 Gene

Additional dbSNP identifiers (rs#s) for MIR4517 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4517 Gene

Variant ID Type Subtype PubMed ID
dgv2830n100 CNV gain 25217958
dgv2831n100 CNV gain 25217958
dgv4987n54 CNV gain 21841781
esv2758640 CNV gain+loss 17122850
esv3570454 CNV gain 25503493
esv3892826 CNV gain+loss 25118596
nsv1059555 CNV gain 25217958
nsv457480 CNV gain 19166990
nsv518648 CNV loss 19592680
nsv519100 CNV gain 19592680
nsv571805 CNV loss 21841781
nsv571808 CNV gain 21841781

Additional Variant Information for MIR4517 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4517

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4517 Gene

Disorders for MIR4517 Gene

Additional Disease Information for MIR4517

No disorders were found for MIR4517 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4517 Gene

Publications for MIR4517 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4517 Gene

Sources for MIR4517 Gene