microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4516 Gene

Subcategory (RNA class) for MIR4516 Gene

miRNA

Number of RNA Genes sources:

4 / 17

Aliases for MIR4516 Gene

  • MicroRNA 4516 2 3 5
  • Hsa-Mir-4516 2 3
  • Hsa-MiR-4516 163 173
  • MIR4516 2 5
  • MIMAT0019053 50
  • MI0016882 50
  • Mir-4516 3

External Ids for MIR4516 Gene

Previous GeneCards Identifiers for MIR4516 Gene

  • GC16U901349
  • GC16P002187
  • GC16P002142
  • GC16P002148
  • GC16P002228
  • GC16P002298
  • GC16P002350
  • GC16P002392
  • GC16P002150
  • GC16P002152
  • GC16P002154
  • GC16P002167
  • GC16P002191
  • GC16P002219
  • GC16P002246
  • GC16P002257

Summaries for MIR4516 Gene

Entrez Gene Summary for MIR4516 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4516 Gene

MIR4516 (MicroRNA 4516) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4516 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4516 Gene

Genomics for MIR4516 Gene

Genomic Locations for MIR4516 Gene

Genomic Locations for MIR4516 Gene
chr16:2,133,119-2,133,204
(GRCh38/hg38)
Size:
86 bases
Orientation:
Plus strand
chr16:2,183,120-2,183,205
(GRCh37/hg19)
Size:
86 bases
Orientation:
Plus strand

Genomic View for MIR4516 Gene

Genes around MIR4516 on UCSC Golden Path with GeneCards custom track
MIR4516 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4516 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4516 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4516 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR4516 Gene

Proteins for MIR4516 Gene

Post-translational modifications for MIR4516 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4516 Gene

Domains & Families for MIR4516 Gene

Gene Families for MIR4516 Gene

HGNC:
genes like me logo Genes that share domains with MIR4516: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4516 Gene

Function for MIR4516 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4516 Gene

Localization for MIR4516 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR4516 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4516 Gene

Pathways & Interactions for MIR4516 Gene

PathCards logo

SuperPathways for MIR4516 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4516 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4516 Gene

Drugs & Compounds for MIR4516 Gene

No Compound Related Data Available

Transcripts for MIR4516 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4516 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075C976_9606 precursor_RNA 86 5

HGNC: 41617,

RefSeq: NR_039741,

Ensembl: ENST00000583451 (view in UCSC) ,

miRBase: MI0016882,

ENA: LM611342.1:1..86:precursor_RNA,

URS00000BF7F9_9606 miRNA 17 5

RefSeq: NR_039741,

LncBase: hsa-miR-4516,

miRBase: MIMAT0019053,

TarBase: hsa-miR-4516,

ENA: LM382433.1:1..17:ncRNA, LM611342.1:2..18:ncRNA,

MIR4516 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR4516 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4516 Gene

No ASD Table

Relevant External Links for MIR4516 Gene

GeneLoc Exon Structure for
MIR4516

Expression for MIR4516 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4516 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR4516

genes like me logo Genes that share expression patterns with MIR4516: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4516 Gene

Orthologs for MIR4516 Gene

Evolution for MIR4516 Gene

ENSEMBL:
Gene Tree for MIR4516 (if available)
TreeFam:
Gene Tree for MIR4516 (if available)

No data available for Orthologs for MIR4516 Gene

Paralogs for MIR4516 Gene

No data available for Paralogs for MIR4516 Gene

Variants for MIR4516 Gene

Additional dbSNP identifiers (rs#s) for MIR4516 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4516 Gene

Variant ID Type Subtype PubMed ID
dgv4859n54 CNV loss 21841781
dgv4861n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
esv26637 CNV loss 19812545
nsv1052260 CNV gain 25217958
nsv457349 CNV loss 19166990
nsv471072 CNV loss 18288195
nsv471381 CNV gain 19718026
nsv482186 CNV gain 20164927
nsv571190 CNV loss 21841781
nsv571197 CNV gain 21841781
nsv827505 CNV gain 20364138
nsv827507 CNV gain 20364138
nsv9332 CNV loss 18304495
nsv952901 CNV deletion 24416366
nsv984250 CNV duplication 23825009

Additional Variant Information for MIR4516 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4516

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4516 Gene

Disorders for MIR4516 Gene

Additional Disease Information for MIR4516

No disorders were found for MIR4516 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4516 Gene

Publications for MIR4516 Gene

  1. The stromal loss of miR-4516 promotes the FOSL1-dependent proliferation and malignancy of triple negative breast cancer. (PMID: 31672492) Kim JE … Cho NH (Cancer letters 2020) 3
  2. miR-4516 predicts poor prognosis and functions as a novel oncogene via targeting PTPN14 in human glioblastoma. (PMID: 30559405) Cui T … Chakravarti A (Oncogene 2019) 3
  3. Long Stress Induced Non-Coding Transcripts 5 (LSINCT5) Promotes Hepatocellular Carcinoma Progression Through Interaction with High-Mobility Group AT-hook 2 and MiR-4516. (PMID: 30472720) Li O … Lei G (Medical science monitor : international medical journal of experimental and clinical research 2018) 3
  4. microRNA-4516 Contributes to Different Functions of Epithelial Permeability Barrier by Targeting Poliovirus Receptor Related Protein 1 in Enterovirus 71 and Coxsackievirus A16 Infections. (PMID: 29686973) Hu Y … Li Q (Frontiers in cellular and infection microbiology 2018) 3
  5. miR-4516, a microRNA downregulated in psoriasis inhibits keratinocyte motility by targeting fibronectin/integrin α9 signaling. (PMID: 28844950) Chowdhari S … Saini N (Biochimica et biophysica acta. Molecular basis of disease 2017) 3

Products for MIR4516 Gene

Sources for MIR4516 Gene