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Aliases for MIR450B Gene

Subcategory (RNA class) for MIR450B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR450B Gene

  • MicroRNA 450b 2 3 5
  • Hsa-Mir-450b 3
  • Mir-450b 3
  • MIRN450B 3

External Ids for MIR450B Gene

Previous HGNC Symbols for MIR450B Gene

  • MIRN450B

Previous GeneCards Identifiers for MIR450B Gene

  • GC0XM133516
  • GC0XM133524
  • GC0XM133674

Summaries for MIR450B Gene

Entrez Gene Summary for MIR450B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR450B Gene

MIR450B (MicroRNA 450b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DNA damage response.

Additional gene information for MIR450B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR450B Gene

Genomics for MIR450B Gene

GeneHancer (GH) Regulatory Elements for MIR450B Gene

Promoters and enhancers for MIR450B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI134675 Enhancer 1 Ensembl ENCODE dbSUPER 12.5 -136.4 -136428 1.9 BCOR JUN ZMYM3 EP300 SP1 MAFF JUND GATA3 ZFP36 FOS LINC00629 MIR450A1 MIR450A2 MIR450B MIR542 MIR503 MIR503HG GC0XP134651 GC0XM134761 RNU4-44P
GH0XI134570 Enhancer 0.7 ENCODE 12.9 -31.6 -31601 3.5 PKNOX1 REST ZIC2 FOXA1 SP1 GATA3 JUND PRDM6 NFIC ZSCAN16 MIR503HG LINC00629 MIR503 MIR450A1 MIR450A2 MIR450B MIR542 ENSG00000235813 PLAC1
GH0XI134751 Enhancer 0.6 ENCODE 13 -212.7 -212671 2.5 CTCF ZNF654 REST RAD21 GATA3 SCRT2 HMBOX1 SMC3 PRDM10 ZBTB17 LINC00629 MIR503 MIR503HG MIR450A1 MIR450A2 MIR450B MIR542 GC0XM134761 RNU4-44P PLAC1
GH0XI134678 Enhancer 0.4 ENCODE 12.5 -139.1 -139138 1.3 SRF SPI1 LINC00629 MIR450A1 MIR450A2 MIR450B MIR542 MIR503 MIR503HG GC0XP134651 GC0XM134761 PLAC1
GH0XI134681 Enhancer 0.2 dbSUPER 12.5 -142.1 -142135 1.3 MIR503 MIR503HG LINC00629 MIR450A1 MIR450A2 MIR450B MIR542 GC0XP134651 GC0XM134761 RNU4-44P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR450B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR450B Gene

Genomic Locations for MIR450B Gene
chrX:134,540,185-134,540,262
(GRCh38/hg38)
Size:
78 bases
Orientation:
Minus strand
chrX:133,674,215-133,674,292
(GRCh37/hg19)

Genomic View for MIR450B Gene

Genes around MIR450B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR450B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR450B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR450B Gene

Proteins for MIR450B Gene

Post-translational modifications for MIR450B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR450B Gene

Domains & Families for MIR450B Gene

Gene Families for MIR450B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR450B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR450B Gene

Function for MIR450B Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR450B Gene

Localization for MIR450B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR450B Gene

Pathways & Interactions for MIR450B Gene

genes like me logo Genes that share pathways with MIR450B: view

Pathways by source for MIR450B Gene

1 BioSystems pathway for MIR450B Gene

Interacting Proteins for MIR450B Gene

Gene Ontology (GO) - Biological Process for MIR450B Gene

None

No data available for SIGNOR curated interactions for MIR450B Gene

Drugs & Compounds for MIR450B Gene

No Compound Related Data Available

Transcripts for MIR450B Gene

mRNA/cDNA for MIR450B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR450B Gene

No ASD Table

Relevant External Links for MIR450B Gene

GeneLoc Exon Structure for
MIR450B
ECgene alternative splicing isoforms for
MIR450B

Expression for MIR450B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR450B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR450B Gene:

MIR450B
genes like me logo Genes that share expression patterns with MIR450B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR450B Gene

Orthologs for MIR450B Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR450B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-450b 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-450b 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-450b 34
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir450b 34
  • 84 (a)
OneToOne
Species where no ortholog for MIR450B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR450B Gene

ENSEMBL:
Gene Tree for MIR450B (if available)
TreeFam:
Gene Tree for MIR450B (if available)

Paralogs for MIR450B Gene

No data available for Paralogs for MIR450B Gene

Variants for MIR450B Gene

Sequence variations from dbSNP and Humsavar for MIR450B Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000102752 -- 134,541,665(-) G/A upstream_transcript_variant
rs1004364929 -- 134,541,852(-) A/C upstream_transcript_variant
rs1004826828 -- 134,540,788(-) C/T upstream_transcript_variant
rs1005199261 -- 134,540,000(-) A/G downstream_transcript_variant
rs1010962031 -- 134,540,056(-) G/C downstream_transcript_variant

Additional Variant Information for MIR450B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR450B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR450B Gene

Disorders for MIR450B Gene

Additional Disease Information for MIR450B

No disorders were found for MIR450B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR450B Gene

Publications for MIR450B Gene

  1. miR-450b-5p Suppresses Stemness and the Development of Chemoresistance by Targeting SOX2 in Colorectal Cancer. (PMID: 26845645) Jin Y … Wang X (DNA and cell biology 2016) 3 58
  2. TGF-β1 suppression of microRNA-450b-5p expression: a novel mechanism for blocking myogenic differentiation of rhabdomyosarcoma. (PMID: 23665678) Sun MM … Wang SL (Oncogene 2014) 3 58
  3. Targeting HER3 with miR-450b-3p suppresses breast cancer cells proliferation. (PMID: 25046105) Zhao Z … Liu T (Cancer biology & therapy 2014) 3 58
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  5. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3 58

Products for MIR450B Gene

Sources for MIR450B Gene

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