microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4506 Gene

Data sources for MIR4506 Gene:

Subcategory (RNA class) for MIR4506 Gene

miRNA

Aliases for MIR4506 Gene

External Ids for MIR4506 Gene

Previous GeneCards Identifiers for MIR4506 Gene

  • GC14U901280
  • GC14M094416

Summaries for MIR4506 Gene

Entrez Gene Summary for MIR4506 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4506 Gene

MIR4506 (MicroRNA 4506) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4506 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4506 Gene

Genomics for MIR4506 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4506 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J093947 Enhancer 0.2 dbSUPER 250.7 +0.0 35 0.7 MIR4506 ENSG00000258987 FAM181A lnc-DDX24-1 ASB2
GH14J093939 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 +8.7 8701 1.2 CTCF REST TRIM22 SMC3 RAD21 SMARCA5 MAX BHLHE40 MAZ ZNF24 ENSG00000258987 HSALNG0103331 FAM181A-AS1 MIR4506 FAM181A ASB2 lnc-DDX24-1
GH14J093944 Enhancer 1 Ensembl ENCODE dbSUPER 0.7 +2.5 2507 3.6 IRF4 BATF ZNF664 IKZF1 NR2F1 ATF2 ZNF652 JUNB ZFP36 GATA2 MIR4506 ENSG00000258987 FAM181A lnc-DDX24-1 ASB2
GH14J093940 Enhancer 0.8 ENCODE dbSUPER 0.4 +6.6 6624 2.6 FEZF1 ZIC2 ZNF513 ZNF843 SPI1 JUND GLIS1 ZNF398 ZNF768 ZNF18 ENSG00000258987 MIR4506 FAM181A ASB2 lnc-DDX24-1
GH14J093951 Enhancer 0.5 dbSUPER 0.7 -3.7 -3703 1.9 ZIC2 BATF MTA3 GLIS1 EP300 HSALNG0103335 ASB2 CCDC197 FAM181A-AS1 MIR4506 lnc-DDX24-1 FAM181A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4506 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4506 Gene

Latest Assembly
chr14:93,948,226-93,948,302
(GRCh38/hg38)
Size:
77 bases
Orientation:
Minus strand

Previous Assembly
chr14:94,414,572-94,414,648
(GRCh37/hg19 by Entrez Gene)
Size:
77 bases
Orientation:
Minus strand

chr14:94,414,572-94,414,648
(GRCh37/hg19 by Ensembl)
Size:
77 bases
Orientation:
Minus strand

Genomic View for MIR4506 Gene

Genes around MIR4506 on UCSC Golden Path with GeneCards custom track
MIR4506 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR4506 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4506 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4506 Gene

Proteins for MIR4506 Gene

Post-translational modifications for MIR4506 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4506 Gene

Domains & Families for MIR4506 Gene

Gene Families for MIR4506 Gene

HGNC:
genes like me logo Genes that share domains with MIR4506: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4506 Gene

Function for MIR4506 Gene

Phenotypes From GWAS Catalog for MIR4506 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4506 Gene

Localization for MIR4506 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4506 Gene

Pathways & Interactions for MIR4506 Gene

PathCards logo

SuperPathways for MIR4506 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4506 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4506 Gene

Drugs & Compounds for MIR4506 Gene

No Compound Related Data Available

Transcripts for MIR4506 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4506 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075A611_9606 precursor_RNA 77 4

RefSeq: NR_039728,

Ensembl: ENST00000584693 (view in UCSC) ,

miRBase: MI0016869,

ENA: LM611336.1:1..77:precursor_RNA,

URS000075D2D9_9606 miRNA 20 3

RefSeq: NR_039728,

miRBase: MIMAT0019042,

ENA: LM382427.1:1..20:ncRNA, LM611336.1:51..70:ncRNA,

MIR4506 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4506 Gene

No ASD Table

Relevant External Links for MIR4506 Gene

GeneLoc Exon Structure for
MIR4506

No data available for mRNA/cDNA for MIR4506 Gene

Expression for MIR4506 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4506 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR4506

genes like me logo Genes that share expression patterns with MIR4506: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4506 Gene

Orthologs for MIR4506 Gene

Evolution for MIR4506 Gene

ENSEMBL:
Gene Tree for MIR4506 (if available)
TreeFam:
Gene Tree for MIR4506 (if available)

No data available for Orthologs for MIR4506 Gene

Paralogs for MIR4506 Gene

No data available for Paralogs for MIR4506 Gene

Variants for MIR4506 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR4506 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for MIR4506 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4506

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR4506 Gene

Disorders for MIR4506 Gene

Additional Disease Information for MIR4506

No disorders were found for MIR4506 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4506 Gene

Publications for MIR4506 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4506 Gene

Sources for MIR4506 Gene