microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR449B Gene

Subcategory (RNA class) for MIR449B Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR449B Gene

  • MicroRNA 449b 2 3 5
  • Hsa-MiR-449b-5p 163 173
  • Hsa-Mir-449b 2 3
  • MIR449B 2 5
  • Hsa-Mir-34-P3b 178
  • MIMAT0003327 50
  • MIMAT0009203 50
  • MI0003673 50
  • MIRN449B 3
  • Mir-449b 3
  • RF00711 168

External Ids for MIR449B Gene

Previous HGNC Symbols for MIR449B Gene

  • MIRN449B

Previous GeneCards Identifiers for MIR449B Gene

  • GC05M054507
  • GC05M054467
  • GC05M054472
  • GC05M054488

Summaries for MIR449B Gene

Entrez Gene Summary for MIR449B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR449B Gene

MIR449B (MicroRNA 449b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are DNA Damage Response and miRNAs involved in DNA damage response.

Rfam classification for MIR449B Gene

Additional gene information for MIR449B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR449B Gene

Genomics for MIR449B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR449B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J054900 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +268.6 268642 4.2 POLR2A RELA TCF12 CTCF PKNOX1 EED CEBPB RUNX3 GATAD2B BCLAF1 GPX8 ENSG00000226810 ENSG00000249016 GZMK MIR449A MIR449B MIR449C CDC20B ENSG00000240535 SNX18
GH05J054906 Enhancer 0.8 Ensembl ENCODE 10.6 +264.3 264305 0.7 CTCF TEAD4 REST RAD21 NFE2 ZNF316 SMC3 TEAD1 MAFG ZNF654 GPX8 ENSG00000249016 GZMK MIR449A MIR449B CDC20B MIR449C ENSG00000240535 ENSG00000226810 SNX18
GH05J054932 Enhancer 0.3 Ensembl 10.4 +237.6 237642 0.6 SMARCA4 ENSG00000249016 GPX8 ENSG00000226810 MIR449A MIR449B MIR449C CDC20B HSALNG0041852 ESM1 SNX18
GH05J054936 Enhancer 0.2 Ensembl 10.4 +234.1 234141 0.4 ENSG00000249016 GPX8 ENSG00000226810 MIR449A MIR449B CDC20B MIR449C HSALNG0041852 ESM1 SNX18
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR449B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR449B Gene

Genomic Locations for MIR449B Gene
chr5:55,170,646-55,170,742
(GRCh38/hg38)
Size:
97 bases
Orientation:
Minus strand
chr5:54,466,474-54,466,570
(GRCh37/hg19)
Size:
97 bases
Orientation:
Minus strand

Genomic View for MIR449B Gene

Genes around MIR449B on UCSC Golden Path with GeneCards custom track
MIR449B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR449B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR449B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR449B Gene

Proteins for MIR449B Gene

Post-translational modifications for MIR449B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR449B Gene

Domains & Families for MIR449B Gene

Gene Families for MIR449B Gene

genes like me logo Genes that share domains with MIR449B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR449B Gene

Function for MIR449B Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR449B Gene

Localization for MIR449B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR449B gene
Compartment Confidence
nucleus 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR449B Gene

Pathways & Interactions for MIR449B Gene

genes like me logo Genes that share pathways with MIR449B: view

Pathways by source for MIR449B Gene

Gene Ontology (GO) - Biological Process for MIR449B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR449B: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR449B Gene

Drugs & Compounds for MIR449B Gene

No Compound Related Data Available

Transcripts for MIR449B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR449B Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075B9B1_9606 precursor_RNA 97 5

HGNC: 32794,

RefSeq: NR_030387,

Ensembl: ENST00000384995 (view in UCSC) ,

miRBase: MI0003673,

ENA: LM609592.1:1..97:precursor_RNA,

URS00003758F0_9606 miRNA 22 5

RefSeq: NR_030387,

LncBase: hsa-miR-449b-5p,

miRBase: MIMAT0003327,

TarBase: hsa-miR-449b-5p,

ENA: LM379889.1:1..22:ncRNA, LM609592.1:16..37:ncRNA,

URS0000490063_9606 miRNA 22 3

RefSeq: NR_030387,

miRBase: MIMAT0009203,

ENA: FM956503.1:1..22:ncRNA, LM609592.1:55..76:ncRNA,

URS0000673896_9606 precursor_RNA 89 1

Rfam: RF00711,

URS0000EFD056_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-34-P3b,

MIR449B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR449B Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR449B Gene

No ASD Table

Relevant External Links for MIR449B Gene

GeneLoc Exon Structure for
MIR449B

Expression for MIR449B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR449B

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR449B Gene

Orthologs for MIR449B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR449B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-449b 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-449b 31
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 92 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir449b 31
  • 86 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-449b 31 31
  • 69 (a)
OneToMany
Chicken
(Gallus gallus)
Aves gga-mir-449b 31
  • 65 (a)
OneToOne
Species where no ortholog for MIR449B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR449B Gene

ENSEMBL:
Gene Tree for MIR449B (if available)
TreeFam:
Gene Tree for MIR449B (if available)

Paralogs for MIR449B Gene

No data available for Paralogs for MIR449B Gene

Variants for MIR449B Gene

Additional dbSNP identifiers (rs#s) for MIR449B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR449B Gene

Variant ID Type Subtype PubMed ID
nsv830302 CNV gain 17160897

Additional Variant Information for MIR449B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR449B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR449B Gene

Disorders for MIR449B Gene

Additional Disease Information for MIR449B

No disorders were found for MIR449B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR449B Gene

Publications for MIR449B Gene

  1. [Effect of CASC19 on proliferation, apoptosis and radiation sensitivity of cervical cancer cells by regulating miR-449b-5p expression]. (PMID: 32074771) Liu YJ … Liu MZ (Zhonghua fu chan ke za zhi 2020) 3
  2. MiR-449b-5p regulates cell proliferation, migration and radioresistance in cervical cancer by interacting with the transcription suppressor FOXP1. (PMID: 31103631) Cheng L … Zhang H (European journal of pharmacology 2019) 3
  3. MicroRNA-449b-5p Suppresses Proliferation, Migration, and Invasion of Osteosarcoma by Targeting c-Met. (PMID: 31425497) Li Q … Gao W (Medical science monitor : international medical journal of experimental and clinical research 2019) 3
  4. MicroRNA-449b-5p suppresses the growth and invasion of breast cancer cells via inhibiting CREPT-mediated Wnt/β-catenin signaling. (PMID: 30738779) Jiang J … Yu S (Chemico-biological interactions 2019) 3
  5. MicroRNA-449b-5p suppresses cell proliferation, migration and invasion by targeting TPD52 in nasopharyngeal carcinoma. (PMID: 31350893) Yin W … Mao Y (Journal of biochemistry 2019) 3

Products for MIR449B Gene

Sources for MIR449B Gene