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Aliases for MIR449A Gene

Subcategory (RNA class) for MIR449A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR449A Gene

  • MicroRNA 449a 2 3 5
  • MicroRNA 449 2 3
  • Hsa-Mir-449a 3
  • Hsa-Mir-449 3
  • Mir-449a 3
  • MIRN449A 3
  • MIRN449 3

External Ids for MIR449A Gene

Previous HGNC Symbols for MIR449A Gene

  • MIRN449
  • MIRN449A

Previous GeneCards Identifiers for MIR449A Gene

  • GC05M054506
  • GC05M054466

Summaries for MIR449A Gene

Entrez Gene Summary for MIR449A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR449A Gene

MIR449A (MicroRNA 449a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNAs involved in DNA damage response and DNA Damage Response.

fRNAdb sequence ontologies for MIR449A Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

Additional gene information for MIR449A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR449A Gene

Genomics for MIR449A Gene

GeneHancer (GH) Regulatory Elements for MIR449A Gene

Promoters and enhancers for MIR449A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I055173 Enhancer 0.8 ENCODE 550.8 -1.6 -1646 0.2 RB1 ZSCAN4 ARID4B SIN3A BMI1 ZNF2 RAD21 RFX5 ZEB1 ZNF335 CDC20B GC05M055174 MIR449A MIR449B MIR449C
GH05I054900 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +268.4 268443 2.7 PKNOX1 MAX EBF1 BATF IRF4 RELA NFATC1 ETV6 FOS BCLAF1 GPX8 LOC100130990 ENSG00000249016 GZMK MIR449A MIR449B CDC20B MIR449C ENSG00000240535 SNX18
GH05I054906 Enhancer 0.6 ENCODE 10.6 +264.5 264484 0.1 CTCF ZNF654 TEAD1 TEAD4 INSM2 MAFG REST RAD21 YY1 TEAD3 GPX8 ENSG00000249016 GZMK MIR449A MIR449B CDC20B MIR449C ENSG00000240535 LOC100130990 SNX18
GH05I055159 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 0.4 +9.8 9831 2.4 FOXA2 INSM2 MZF1 SIN3A BRCA1 ZNF2 RAD21 RFX5 ZNF335 ZNF366 GPX8 CCNO LOC105378973 ENSG00000249016 LOC100130990 SNX18 CDC20B MIR449A
GH05I055162 Enhancer 0.3 ENCODE 0.4 +7.8 7774 0.2 USF2 LOC105378973 CCNO SNX18 GPX8 MIR449A CDC20B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR449A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR449A Gene

Genomic Locations for MIR449A Gene
chr5:55,170,532-55,170,622
(GRCh38/hg38)
Size:
91 bases
Orientation:
Minus strand
chr5:54,466,360-54,466,450
(GRCh37/hg19)

Genomic View for MIR449A Gene

Genes around MIR449A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR449A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR449A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR449A Gene

ORGUL Member Location for MIR449A Gene

ORGUL Member Location for MIR449A gene

Proteins for MIR449A Gene

Post-translational modifications for MIR449A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR449A Gene

Domains & Families for MIR449A Gene

Gene Families for MIR449A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR449A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR449A Gene

Function for MIR449A Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR449A Gene

Localization for MIR449A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR449A Gene

Pathways & Interactions for MIR449A Gene

genes like me logo Genes that share pathways with MIR449A: view

Pathways by source for MIR449A Gene

1 KEGG pathway for MIR449A Gene

Interacting Proteins for MIR449A Gene

Gene Ontology (GO) - Biological Process for MIR449A Gene

None

No data available for SIGNOR curated interactions for MIR449A Gene

Drugs & Compounds for MIR449A Gene

No Compound Related Data Available

Transcripts for MIR449A Gene

mRNA/cDNA for MIR449A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR449A Gene

No ASD Table

Relevant External Links for MIR449A Gene

GeneLoc Exon Structure for
MIR449A
ECgene alternative splicing isoforms for
MIR449A

Expression for MIR449A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR449A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR449A Gene:

MIR449A
genes like me logo Genes that share expression patterns with MIR449A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR449A Gene

Orthologs for MIR449A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR449A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-449a 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-449 34
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-449a 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir449a 34
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-449a 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-449a 34
  • 63 (a)
OneToMany
-- 34
  • 62 (a)
OneToMany
chicken
(Gallus gallus)
Aves gga-mir-449a 34
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-449a 34
  • 72 (a)
OneToOne
Species where no ortholog for MIR449A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR449A Gene

ENSEMBL:
Gene Tree for MIR449A (if available)
TreeFam:
Gene Tree for MIR449A (if available)

Paralogs for MIR449A Gene

No data available for Paralogs for MIR449A Gene

Variants for MIR449A Gene

Sequence variations from dbSNP and Humsavar for MIR449A Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000390144 -- 55,170,864(-) A/G upstream_transcript_variant
rs1000759722 -- 55,171,151(-) T/A upstream_transcript_variant
rs1001054977 -- 55,170,260(-) C/T downstream_transcript_variant
rs1001785608 -- 55,172,453(-) T/G upstream_transcript_variant
rs1004125397 -- 55,172,042(-) C/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR449A Gene

Variant ID Type Subtype PubMed ID
nsv830302 CNV gain 17160897

Additional Variant Information for MIR449A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR449A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR449A Gene

Disorders for MIR449A Gene

Additional Disease Information for MIR449A

No disorders were found for MIR449A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR449A Gene

Publications for MIR449A Gene

  1. Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. (PMID: 15735639) Xie X … Kellis M (Nature 2005) 1 3 58
  2. Hsa_circ_0009910 promotes carcinogenesis by promoting the expression of miR-449a target IL6R in osteosarcoma. (PMID: 29117539) Deng N … Liu Y (Biochemical and biophysical research communications 2018) 3 58
  3. Characterizing isomiR variants within the microRNA-34/449 family. (PMID: 28192603) Mercey O … Marcet B (FEBS letters 2017) 3 58
  4. The microRNA-449 family inhibits TGF-β-mediated liver cancer cell migration by targeting SOX4. (PMID: 28088579) Sandbothe M … Skawran B (Journal of hepatology 2017) 3 58
  5. Mir-449a, a potential diagnostic biomarker for WNT group of medulloblastoma. (PMID: 27406588) Li Y … Chang Q (Journal of neuro-oncology 2016) 3 58

Products for MIR449A Gene

Sources for MIR449A Gene

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