microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR449A Gene

Subcategory (RNA class) for MIR449A Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR449A Gene

  • MicroRNA 449a 2 3 5
  • MicroRNA 449 2 3
  • Hsa-Mir-449a 2 3
  • Hsa-MiR-449a 163 173
  • Hsa-Mir-449 2 3
  • MIR449A 2 5
  • Hsa-Mir-34-P3a 178
  • MIMAT0001541 50
  • MI0001648 50
  • MIRN449A 3
  • Mir-449a 3
  • MIRN449 3
  • RF00711 168

External Ids for MIR449A Gene

Previous HGNC Symbols for MIR449A Gene

  • MIRN449
  • MIRN449A

Previous GeneCards Identifiers for MIR449A Gene

  • GC05M054506
  • GC05M054466

Summaries for MIR449A Gene

Entrez Gene Summary for MIR449A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR449A Gene

MIR449A (MicroRNA 449a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR449A include Prostate Cancer. Among its related pathways are DNA Damage Response and MicroRNAs in cancer.

Rfam classification for MIR449A Gene

Additional gene information for MIR449A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR449A Gene

Genomics for MIR449A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR449A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR449A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR449A Gene

Genomic Locations for MIR449A Gene
chr5:55,170,532-55,170,622
(GRCh38/hg38)
Size:
91 bases
Orientation:
Minus strand
chr5:54,466,360-54,466,450
(GRCh37/hg19)
Size:
91 bases
Orientation:
Minus strand

Genomic View for MIR449A Gene

Genes around MIR449A on UCSC Golden Path with GeneCards custom track
MIR449A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR449A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR449A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR449A Gene

Proteins for MIR449A Gene

Post-translational modifications for MIR449A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR449A Gene

Domains & Families for MIR449A Gene

Gene Families for MIR449A Gene

genes like me logo Genes that share domains with MIR449A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR449A Gene

Function for MIR449A Gene

Gene Ontology (GO) - Molecular Function for MIR449A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 24429361
genes like me logo Genes that share ontologies with MIR449A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR449A Gene

Localization for MIR449A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR449A gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR449A Gene

Pathways & Interactions for MIR449A Gene

genes like me logo Genes that share pathways with MIR449A: view

Pathways by source for MIR449A Gene

1 KEGG pathway for MIR449A Gene

Gene Ontology (GO) - Biological Process for MIR449A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 25487955
GO:0010629 negative regulation of gene expression IDA 25487955
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling IDA 25487955
GO:0030336 negative regulation of cell migration IDA 25487955
GO:0035195 gene silencing by miRNA IDA,IEA --
genes like me logo Genes that share ontologies with MIR449A: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR449A Gene

Drugs & Compounds for MIR449A Gene

No Compound Related Data Available

Transcripts for MIR449A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR449A Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00006A0D74_9606 precursor_RNA 91 6

HGNC: 27645,

RefSeq: NR_029960,

Ensembl: ENST00000362113 (view in UCSC) ,

miRBase: MI0001648,

Rfam: RF00711,

ENA: LM609022.1:1..91:precursor_RNA,

URS00001F5B39_9606 miRNA 22 6

RefSeq: NR_029960,

LncBase: hsa-miR-449a,

miRBase: MIMAT0001541,

MirGeneDB: Hsa-Mir-34-P3a_5p,

TarBase: hsa-miR-449a,

ENA: LM379509.1:1..22:ncRNA, LM609022.1:16..37:ncRNA,

URS0000EFD5EA_9606 precursor_RNA 63 1

MirGeneDB: Hsa-Mir-34-P3a,

URS0000EFE90F_9606 miRNA 22 1

MirGeneDB: Hsa-Mir-34-P3a_3p,

MIR449A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR449A Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR449A Gene

No ASD Table

Relevant External Links for MIR449A Gene

GeneLoc Exon Structure for
MIR449A

Expression for MIR449A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR449A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR449A

genes like me logo Genes that share expression patterns with MIR449A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR449A Gene

Orthologs for MIR449A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR449A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-449a 31
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-449 31
  • 93 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-449a 31
  • 91 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir449a 31
  • 86 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia mdo-mir-449a 31
  • 77 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-449a 31
  • 63 (a)
OneToMany
-- 31
  • 62 (a)
OneToMany
Chicken
(Gallus gallus)
Aves gga-mir-449a 31
  • 76 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia aca-mir-449a 31
  • 72 (a)
OneToOne
Species where no ortholog for MIR449A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR449A Gene

ENSEMBL:
Gene Tree for MIR449A (if available)
TreeFam:
Gene Tree for MIR449A (if available)

Paralogs for MIR449A Gene

No data available for Paralogs for MIR449A Gene

Variants for MIR449A Gene

Additional dbSNP identifiers (rs#s) for MIR449A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR449A Gene

Variant ID Type Subtype PubMed ID
nsv830302 CNV gain 17160897

Additional Variant Information for MIR449A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR449A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR449A Gene

Disorders for MIR449A Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR449A Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR449A

genes like me logo Genes that share disorders with MIR449A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR449A Gene

Publications for MIR449A Gene

  1. Expression Level of MicroRNA-449a Predicts the Prognosis of Patients With Gastric Cancer. (PMID: 31892572) Ishikawa D … Shimada M (Anticancer research 2020) 3
  2. The microRNAs miR-449a and miR-424 suppress osteosarcoma by targeting cyclin A2 expression. (PMID: 30679313) Shekhar R … Saxena S (The Journal of biological chemistry 2019) 3
  3. Flot2 targeted by miR-449 acts as a prognostic biomarker in glioma. (PMID: 30663389) Huang S … Lin W (Artificial cells, nanomedicine, and biotechnology 2019) 3
  4. The Significance of MicroRNA-449a and Its Potential Target HDAC1 in Patients With Colorectal Cancer. (PMID: 31177123) Ishikawa D … Shimada M (Anticancer research 2019) 3
  5. miR-449a inhibits cell proliferation, migration, and inflammation by regulating high-mobility group box protein 1 and forms a mutual inhibition loop with Yin Yang 1 in rheumatoid arthritis fibroblast-like synoviocytes. (PMID: 31159863) Cai Y … Qiu Y (Arthritis research & therapy 2019) 3

Products for MIR449A Gene

Sources for MIR449A Gene