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Aliases for MIR4497 Gene

Subcategory (RNA class) for MIR4497 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR4497 Gene

  • MicroRNA 4497 2 3 5
  • Hsa-Mir-4497 3
  • Mir-4497 3

External Ids for MIR4497 Gene

Previous GeneCards Identifiers for MIR4497 Gene

  • GC12U901598
  • GC12P110272

Summaries for MIR4497 Gene

Entrez Gene Summary for MIR4497 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4497 Gene

MIR4497 (MicroRNA 4497) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4497 include Scapuloperoneal Spinal Muscular Atrophy and Brachyolmia.

Additional gene information for MIR4497 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4497 Gene

Genomics for MIR4497 Gene

GeneHancer (GH) Regulatory Elements for MIR4497 Gene

Promoters and enhancers for MIR4497 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J109833 Promoter 1.4 EPDnew Ensembl 600.7 0.0 -47 1.8 ZNF121 ZNF24 ZIC2 POLR2A ZFHX2 ELF1 GLIS1 KDM1A ZMYM3 TRPV4 MIR4497 GLTP GPN3 FAM222A-AS1
GH12J109822 Enhancer 1.1 FANTOM5 ENCODE 0.4 -10.3 -10262 1.3 ELF3 TFE3 SP5 KAT8 GLIS2 HMG20B ZIC2 GATAD2A NFKBIZ RXRB TRPV4 MIR4497 FAM222A-AS1
GH12J109827 Enhancer 0.8 FANTOM5 ENCODE 0.4 -5.1 -5065 0.4 SP1 ZSCAN4 CTCF STAT5A RXRA GIT2 ANKRD13A GLTP MIR4497 TRPV4 FAM222A-AS1
GH12J109820 Enhancer 0.8 ENCODE 0.4 -12.2 -12217 0.9 CEBPG SP7 PRDM1 ZBTB8A ZNF600 PRDM10 ZIC2 ZEB2 ZNF629 PATZ1 MIR4497 TRPV4 FAM222A-AS1
GH12J109805 Enhancer 1 Ensembl ENCODE 0.3 -27.7 -27747 0.8 CTCF CEBPG RAD21 RXRA RELA CEBPA GATAD2A ZNF143 REST RXRB GLTP MIR4497 TRPV4 FAM222A-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4497 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4497 Gene

Genomic Locations for MIR4497 Gene
chr12:109,833,348-109,833,436
(GRCh38/hg38)
Size:
89 bases
Orientation:
Plus strand
chr12:110,271,153-110,271,241
(GRCh37/hg19)
Size:
89 bases
Orientation:
Plus strand

Genomic View for MIR4497 Gene

Genes around MIR4497 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4497 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4497 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4497 Gene

Proteins for MIR4497 Gene

Post-translational modifications for MIR4497 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4497 Gene

Domains & Families for MIR4497 Gene

Gene Families for MIR4497 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4497: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4497 Gene

Function for MIR4497 Gene

Phenotypes From GWAS Catalog for MIR4497 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4497 Gene

Localization for MIR4497 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4497 Gene

Pathways & Interactions for MIR4497 Gene

PathCards logo

SuperPathways for MIR4497 Gene

No Data Available

Interacting Proteins for MIR4497 Gene

Gene Ontology (GO) - Biological Process for MIR4497 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4497 Gene

Drugs & Compounds for MIR4497 Gene

No Compound Related Data Available

Transcripts for MIR4497 Gene

mRNA/cDNA for MIR4497 Gene

(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNA Central transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4497 Gene

No ASD Table

Relevant External Links for MIR4497 Gene

GeneLoc Exon Structure for
MIR4497
ECgene alternative splicing isoforms for
MIR4497

Expression for MIR4497 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4497 Gene

mRNA differential expression in normal tissues according to GTEx for MIR4497 Gene

This gene is overexpressed in Minor Salivary Gland (x10.9), Esophagus - Mucosa (x6.4), and Kidney - Cortex (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of MIR4497 Gene:

MIR4497
genes like me logo Genes that share expression patterns with MIR4497: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4497 Gene

Orthologs for MIR4497 Gene

Evolution for MIR4497 Gene

ENSEMBL:
Gene Tree for MIR4497 (if available)
TreeFam:
Gene Tree for MIR4497 (if available)

No data available for Orthologs for MIR4497 Gene

Paralogs for MIR4497 Gene

No data available for Paralogs for MIR4497 Gene

Variants for MIR4497 Gene

Sequence variations from dbSNP and Humsavar for MIR4497 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs56079803 likely-benign, Charcot-Marie-Tooth disease, type 2, Scapuloperoneal spinal muscular atrophy, Distal spinal muscular atrophy, congenital nonprogressive, Brachyolmia, Metatrophic dysplasia, Spondylometaphyseal dysplasia 109,833,413(+) C/T non_coding_transcript_variant
rs886048942 uncertain-significance, Spondylometaphyseal dysplasia, Brachyolmia, Distal spinal muscular atrophy, congenital nonprogressive, Charcot-Marie-Tooth disease, type 2, Metatrophic dysplasia, Scapuloperoneal spinal muscular atrophy 109,833,392(+) C/G/T non_coding_transcript_variant
rs1403366205 likely-benign, not specified 109,833,369(+) C/T non_coding_transcript_variant
rs1000648757 -- 109,832,927(+) C/T upstream_transcript_variant
rs1002233901 -- 109,833,429(+) C/T non_coding_transcript_variant

Additional Variant Information for MIR4497 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4497

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR4497 Gene

Disorders for MIR4497 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR4497 Gene - From: GeneCards

Disorder Aliases PubMed IDs
scapuloperoneal spinal muscular atrophy
  • spsma
brachyolmia
  • brachyrachia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR4497

genes like me logo Genes that share disorders with MIR4497: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR4497 Gene

Publications for MIR4497 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 58
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4497 Gene

Sources for MIR4497 Gene

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