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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR4493 (MicroRNA 4493) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH11J123381 | Enhancer | 0.9 | Ensembl ENCODE | 600.7 | -0.6 | -599 | 2.2 | SP1 STAT3 ZNF143 RELA IKZF2 RCOR1 EED CEBPB ARID3A DPF2 | MIR4493 GRAMD1B lnc-OR8D4-1 SCN3B | |
GH11J123425 | Promoter/Enhancer | 1.8 | Ensembl ENCODE CraniofacialAtlas dbSUPER | 0.3 | -48.0 | -47984 | 7.4 | KDM1A LARP7 ZNF143 ZIC2 PATZ1 IKZF2 RCOR1 TRIM22 POLR2A ZNF341 | lnc-OR8D4-1 MIR4493 GRAMD1B SCN3B | |
GH11J123377 | Enhancer | 0.7 | Ensembl ENCODE | 0.7 | +3.6 | 3627 | 3 | RELA SCRT2 EED RUNX3 SCRT1 TCF7L2 GATA2 | MIR4493 lnc-CLMP-8 GRAMD1B SCN3B | |
GH11J123449 | Promoter/Enhancer | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 0.2 | -72.8 | -72839 | 9.3 | ZNF629 ZNF512 RFX1 BACH1 JUND TCF12 REST IKZF2 SOX6 PKNOX1 | lnc-OR8D4-1 GRAMD1B MIR4493 SCN3B | |
GH11J123404 | Enhancer | 0.8 | Ensembl ENCODE | 0.4 | -23.7 | -23689 | 1.2 | PRDM1 ZSCAN4 IKZF2 PKNOX1 DPF2 RUNX3 GATAD2B NBN HDGF IKZF1 | MIR4493 lnc-OR8D4-1 GRAMD1B SCN3B |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075A151_9606 | precursor_RNA | 73 | 4 |
HGNC: 41778, RefSeq: NR_039714, Ensembl: ENST00000584016 (view in UCSC) , miRBase: MI0016855, |
URS000075E54E_9606 | miRNA | 21 | 2 |
RefSeq: NR_039714, miRBase: MIMAT0019028, |
No disorders were found for MIR4493 Gene.