microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4493 Gene

Data sources for MIR4493 Gene:

RNA type for MIR4493 Gene

miRNA

Aliases for MIR4493 Gene

External Ids for MIR4493 Gene

Previous GeneCards Identifiers for MIR4493 Gene

  • GC11U901854
  • GC11M123254

Summaries for MIR4493 Gene

Entrez Gene Summary for MIR4493 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4493 Gene

MIR4493 (MicroRNA 4493) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4493 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4493 Gene

Genomics for MIR4493 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4493 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J123381 Enhancer 0.9 Ensembl ENCODE 250.7 -0.6 -599 2.2 BCLAF1 SP1 BCL11A IRF4 EBF1 CBFB MAX SMARCA5 BHLHE40 BATF MIR4493 GRAMD1B HSALNG0087833 SCN3B
GH11J123380 Enhancer 0.2 Ensembl 250.7 +0.6 611 0.2 MIR4493 lnc-CLMP-8 GRAMD1B SCN3B
GH11J123425 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.3 -48.0 -47984 7.4 BCLAF1 ZNF207 POLR2A ZIC2 TRIM22 ZNF341 SIN3A GABPA SP2 RFX5 HSALNG0087833 MIR4493 GRAMD1B SCN3B
GH11J123377 Enhancer 0.6 Ensembl ENCODE 0.7 +3.5 3511 2.8 TCF7L2 SCRT1 GATA2 EED RUNX3 SCRT2 MIR4493 lnc-CLMP-8 GRAMD1B SCN3B
GH11J123404 Enhancer 0.8 Ensembl ENCODE 0.4 -23.7 -23689 2.8 SPI1 STAT5A IKZF1 HDGF NR2F1 MTA3 ATF2 JUNB PKNOX1 ZSCAN4 MIR4493 HSALNG0087833 GRAMD1B SCN3B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4493 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4493 Gene

Latest Assembly
chr11:123,381,440-123,381,512
(GRCh38/hg38)
Size:
73 bases
Orientation:
Minus strand

Previous Assembly
chr11:123,252,148-123,252,220
(GRCh37/hg19 by Entrez Gene)
Size:
73 bases
Orientation:
Minus strand

chr11:123,252,148-123,252,220
(GRCh37/hg19 by Ensembl)
Size:
73 bases
Orientation:
Minus strand

Genomic View for MIR4493 Gene

Genes around MIR4493 on UCSC Golden Path with GeneCards custom track
MIR4493 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR4493 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4493 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4493 Gene

Proteins for MIR4493 Gene

Post-translational modifications for MIR4493 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4493 Gene

Domains & Families for MIR4493 Gene

Gene Families for MIR4493 Gene

HGNC:
genes like me logo Genes that share domains with MIR4493: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4493 Gene

Function for MIR4493 Gene

Phenotypes From GWAS Catalog for MIR4493 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4493 Gene

Localization for MIR4493 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4493 Gene

Pathways & Interactions for MIR4493 Gene

PathCards logo

SuperPathways for MIR4493 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4493 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4493 Gene

Drugs & Compounds for MIR4493 Gene

No Compound Related Data Available

Transcripts for MIR4493 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4493 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000075A151_9606 precursor_RNA 73 3

RefSeq: NR_039714,

Ensembl: ENST00000584016 (view in UCSC) ,

miRBase: MI0016855,

URS000075E54E_9606 miRNA 21 2

RefSeq: NR_039714,

miRBase: MIMAT0019028,

MIR4493 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4493 Gene

No ASD Table

Relevant External Links for MIR4493 Gene

GeneLoc Exon Structure for
MIR4493

No data available for mRNA/cDNA for MIR4493 Gene

Expression for MIR4493 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR4493

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4493 Gene

Orthologs for MIR4493 Gene

Evolution for MIR4493 Gene

ENSEMBL:
Gene Tree for MIR4493 (if available)
TreeFam:
Gene Tree for MIR4493 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR4493

No data available for Orthologs for MIR4493 Gene

Paralogs for MIR4493 Gene

No data available for Paralogs for MIR4493 Gene

Variants for MIR4493 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR4493 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for MIR4493 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4493
Leiden Open Variation Database (LOVD)
MIR4493

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR4493 Gene

Disorders for MIR4493 Gene

Additional Disease Information for MIR4493

No disorders were found for MIR4493 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4493 Gene

Publications for MIR4493 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4493 Gene

Sources for MIR4493 Gene