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Aliases for MIR4491 Gene

Subcategory (RNA class) for MIR4491 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR4491 Gene

  • MicroRNA 4491 2 3 5
  • Hsa-Mir-4491 3
  • Mir-4491 3

External Ids for MIR4491 Gene

Previous GeneCards Identifiers for MIR4491 Gene

  • GC11U901870
  • GC11P111220

Summaries for MIR4491 Gene

Entrez Gene Summary for MIR4491 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4491 Gene

MIR4491 (MicroRNA 4491) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4491 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4491 Gene

Genomics for MIR4491 Gene

GeneHancer (GH) Regulatory Elements for MIR4491 Gene

Promoters and enhancers for MIR4491 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J111357 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 0.4 +17.1 17147 15.7 HDGF PKNOX1 FOXA2 SMAD1 MLX ZFP64 ARID4B DMAP1 YBX1 IRF4 COLCA2 COLCA1 LAYN BTG4 C11orf88 MIR34B MIR34C POU2AF1 MIR4491 RNU2-60P
GH11J111375 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 0.3 +30.7 30730 5.1 HDGF PKNOX1 RB1 BMI1 BATF KLF5 IRF4 ZBTB40 ZNF207 ZNF143 POU2AF1 COLCA1 COLCA2 LOC644277 BTG4 C11orf88 MIR34B MIR34C RNU2-60P MIR4491
GH11J111351 Enhancer 0.7 dbSUPER 0.7 +3.7 3686 0.7 DRAP1 ELF3 FOXA2 MZF1 FEZF1 ZNF644 ZNF335 MIXL1 GATAD2A SOX5 COLCA1 COLCA2 RNU2-60P MIR4491
GH11J111333 Enhancer 1.2 ENCODE dbSUPER 0.4 -12.2 -12192 3.5 FOXA2 MLX ARID4B DMAP1 ETS1 YY1 ZNF121 RXRA SP5 MIER2 COLCA1 COLCA2 LOC105369491 MIR4491
GH11J111352 Enhancer 0.8 ENCODE dbSUPER 0.4 +5.4 5418 1.6 STAT1 FOXA2 RAD21 PCBP2 ZFHX2 ZNF366 ETV6 EGR2 COLCA1 COLCA2 RNU2-60P RPS6P16 MIR4491 POU2AF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4491 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4491 Gene

Genomic Locations for MIR4491 Gene
chr11:111,347,757-111,347,824
(GRCh38/hg38)
Size:
68 bases
Orientation:
Plus strand
chr11:111,218,482-111,218,549
(GRCh37/hg19)
Size:
68 bases
Orientation:
Plus strand

Genomic View for MIR4491 Gene

Genes around MIR4491 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4491 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4491 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4491 Gene

Proteins for MIR4491 Gene

Post-translational modifications for MIR4491 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4491 Gene

Domains & Families for MIR4491 Gene

Gene Families for MIR4491 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4491: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4491 Gene

Function for MIR4491 Gene

Phenotypes From GWAS Catalog for MIR4491 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4491 Gene

Localization for MIR4491 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4491 Gene

Pathways & Interactions for MIR4491 Gene

SuperPathways for MIR4491 Gene

No Data Available

Interacting Proteins for MIR4491 Gene

Gene Ontology (GO) - Biological Process for MIR4491 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4491 Gene

Drugs & Compounds for MIR4491 Gene

No Compound Related Data Available

Transcripts for MIR4491 Gene

mRNA/cDNA for MIR4491 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(2) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4491 Gene

No ASD Table

Relevant External Links for MIR4491 Gene

GeneLoc Exon Structure for
MIR4491
ECgene alternative splicing isoforms for
MIR4491

Expression for MIR4491 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4491 Gene:

MIR4491
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4491 Gene

Orthologs for MIR4491 Gene

Evolution for MIR4491 Gene

ENSEMBL:
Gene Tree for MIR4491 (if available)
TreeFam:
Gene Tree for MIR4491 (if available)

No data available for Orthologs for MIR4491 Gene

Paralogs for MIR4491 Gene

No data available for Paralogs for MIR4491 Gene

Variants for MIR4491 Gene

Sequence variations from dbSNP and Humsavar for MIR4491 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1001202415 -- 111,347,377(+) T/C upstream_transcript_variant
rs1001303152 -- 111,348,199(+) G/A downstream_transcript_variant
rs1002899711 -- 111,347,304(+) A/G upstream_transcript_variant
rs1003388323 -- 111,346,959(+) G/A upstream_transcript_variant
rs1004252157 -- 111,346,299(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4491 Gene

Variant ID Type Subtype PubMed ID
nsv832268 CNV loss 17160897
nsv490 CNV deletion 18451855
esv3627737 CNV gain 21293372
esv3627736 CNV loss 21293372
esv3627735 CNV loss 21293372
esv2666308 CNV deletion 23128226

Additional Variant Information for MIR4491 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4491

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4491 Gene

Disorders for MIR4491 Gene

Additional Disease Information for MIR4491

No disorders were found for MIR4491 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4491 Gene

Publications for MIR4491 Gene

  1. Identification of cardiac-related circulating microRNA profile in human chronic heart failure. (PMID: 26683101) Li H … Wang DW (Oncotarget 2016) 3 58
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  3. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 58
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4491 Gene

Sources for MIR4491 Gene

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