microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4491 Gene

Data sources for MIR4491 Gene:

RNA type for MIR4491 Gene


Aliases for MIR4491 Gene

External Ids for MIR4491 Gene

Previous GeneCards Identifiers for MIR4491 Gene

  • GC11U901870
  • GC11P111220

Summaries for MIR4491 Gene

Entrez Gene Summary for MIR4491 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4491 Gene

MIR4491 (MicroRNA 4491) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4491 Gene

Genomics for MIR4491 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4491 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J111348 Enhancer 0.6 Ensembl dbSUPER 250.7 +1.5 1544 1.4 IKZF1 PKNOX1 ARID3A IKZF2 MTA2 DPF2 MIR4491 COLCA2 COLCA1 HSALNG0087098 HSALNG0087096 POU2AF1
GH11J111351 Enhancer 0.8 Ensembl dbSUPER 0.7 +3.7 3744 0.2 FEZF1 FOXA2 ZNF843 FOXP1 NRF1 HHEX GATA4 POLR2A TRIM28 NFIL3 COLCA1 HSALNG0087098 MIR4491 COLCA2 POU2AF1
GH11J111352 Enhancer 0.8 Ensembl ENCODE dbSUPER 0.4 +5.4 5418 1.6 POLR2A ZNF366 RAD21 EGR2 YY1 ETV6 ZFHX2 HSALNG0087098 COLCA1 COLCA2 RNU2-60P MIR4491 lnc-BTG4-3 POU2AF1
GH11J111344 Enhancer 0.5 Ensembl 0.7 -3.4 -3357 0.4 NFE2 NFE2L2 ATF4 MAFK IKZF1 CEBPB ZBTB20 HSALNG0087096 COLCA1 COLCA2 MIR4491 POU2AF1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4491 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4491 Gene

Latest Assembly
68 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
68 bases
Plus strand

(GRCh37/hg19 by Ensembl)
68 bases
Plus strand

Genomic View for MIR4491 Gene

Genes around MIR4491 on UCSC Golden Path with GeneCards custom track
MIR4491 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR4491 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4491 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4491 Gene

Proteins for MIR4491 Gene

Post-translational modifications for MIR4491 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4491 Gene

Domains & Families for MIR4491 Gene

Gene Families for MIR4491 Gene

genes like me logo Genes that share domains with MIR4491: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4491 Gene

Function for MIR4491 Gene

Phenotypes From GWAS Catalog for MIR4491 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4491 Gene

Localization for MIR4491 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR4491 gene
Compartment Confidence
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4491 Gene

Pathways & Interactions for MIR4491 Gene

PathCards logo

SuperPathways for MIR4491 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4491 Gene


No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4491 Gene

Drugs & Compounds for MIR4491 Gene

No Compound Related Data Available

Transcripts for MIR4491 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4491 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS0000759EB8_9606 miRNA 22 5

RefSeq: NR_039712,

LncBase: hsa-miR-4491,

miRBase: MIMAT0019026,

TarBase: hsa-miR-4491,

ENA: LM382420.1:1..22:ncRNA, LM611329.1:46..67:ncRNA,

URS0000759FFE_9606 precursor_RNA 68 4

RefSeq: NR_039712,

Ensembl: ENST00000581087 (view in UCSC) ,

miRBase: MI0016853,

ENA: LM611329.1:1..68:precursor_RNA,

MIR4491 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR4491 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4491 Gene

No ASD Table

Relevant External Links for MIR4491 Gene

GeneLoc Exon Structure for

Expression for MIR4491 Gene

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4491 Gene

Orthologs for MIR4491 Gene

Evolution for MIR4491 Gene

Gene Tree for MIR4491 (if available)
Gene Tree for MIR4491 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR4491

No data available for Orthologs for MIR4491 Gene

Paralogs for MIR4491 Gene

No data available for Paralogs for MIR4491 Gene

Variants for MIR4491 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR4491 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR4491 Gene

Variant ID Type Subtype PubMed ID
esv2666308 CNV deletion 23128226
esv3627735 CNV loss 21293372
esv3627736 CNV loss 21293372
esv3627737 CNV gain 21293372
nsv490 CNV deletion 18451855
nsv832268 CNV loss 17160897

Additional Variant Information for MIR4491 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4491 Gene

Disorders for MIR4491 Gene

Additional Disease Information for MIR4491

No disorders were found for MIR4491 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4491 Gene

Publications for MIR4491 Gene

  1. Identification of cardiac-related circulating microRNA profile in human chronic heart failure. (PMID: 26683101) Li H … Wang DW (Oncotarget 2016) 3
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  3. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4491 Gene

Sources for MIR4491 Gene