microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4490 Gene

Subcategory (RNA class) for MIR4490 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR4490 Gene

  • MicroRNA 4490 2 3 5
  • Hsa-Mir-4490 2 3
  • MIR4490 2 5
  • MIMAT0019025 50
  • MI0016852 50

External Ids for MIR4490 Gene

Previous GeneCards Identifiers for MIR4490 Gene

  • GC11U901883
  • GC11M090290

Summaries for MIR4490 Gene

Entrez Gene Summary for MIR4490 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4490 Gene

MIR4490 (MicroRNA 4490) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4490 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4490 Gene

Genomics for MIR4490 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4490 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J090531 Enhancer 0.2 Ensembl 0.4 +23.8 23756 0.6 piR-54987-022 MIR4490 DISC1FP1 CHORDC1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4490 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4490 Gene

Genomic Locations for MIR4490 Gene
chr11:90,555,774-90,555,857
(GRCh38/hg38)
Size:
84 bases
Orientation:
Minus strand
chr11:90,288,942-90,289,025
(GRCh37/hg19)
Size:
84 bases
Orientation:
Minus strand

Genomic View for MIR4490 Gene

Genes around MIR4490 on UCSC Golden Path with GeneCards custom track
MIR4490 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4490 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4490 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4490 Gene

Proteins for MIR4490 Gene

Post-translational modifications for MIR4490 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4490 Gene

Domains & Families for MIR4490 Gene

Gene Families for MIR4490 Gene

HGNC:
genes like me logo Genes that share domains with MIR4490: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4490 Gene

Function for MIR4490 Gene

Phenotypes From GWAS Catalog for MIR4490 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4490 Gene

Localization for MIR4490 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4490 Gene

Pathways & Interactions for MIR4490 Gene

PathCards logo

SuperPathways for MIR4490 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4490 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4490 Gene

Drugs & Compounds for MIR4490 Gene

No Compound Related Data Available

Transcripts for MIR4490 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4490 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075D402_9606 precursor_RNA 84 4

HGNC: 41871,

RefSeq: NR_039711,

Ensembl: ENST00000582647 (view in UCSC) ,

miRBase: MI0016852,

URS000075ABA2_9606 miRNA 22 2

RefSeq: NR_039711,

miRBase: MIMAT0019025,

MIR4490 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4490 Gene

No ASD Table

Relevant External Links for MIR4490 Gene

GeneLoc Exon Structure for
MIR4490

No data available for mRNA/cDNA for MIR4490 Gene

Expression for MIR4490 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4490 Gene

Orthologs for MIR4490 Gene

Evolution for MIR4490 Gene

ENSEMBL:
Gene Tree for MIR4490 (if available)
TreeFam:
Gene Tree for MIR4490 (if available)

No data available for Orthologs for MIR4490 Gene

Paralogs for MIR4490 Gene

No data available for Paralogs for MIR4490 Gene

Variants for MIR4490 Gene

Additional dbSNP identifiers (rs#s) for MIR4490 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4490 Gene

Variant ID Type Subtype PubMed ID
esv3579993 CNV gain 25503493
esv3627209 CNV loss 21293372
esv3892062 CNV loss 25118596
esv3892063 CNV loss 25118596
nsv1039065 CNV gain 25217958
nsv1048624 CNV loss 25217958
nsv1053196 CNV loss 25217958

Additional Variant Information for MIR4490 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4490

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4490 Gene

Disorders for MIR4490 Gene

Additional Disease Information for MIR4490

No disorders were found for MIR4490 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4490 Gene

Publications for MIR4490 Gene

  1. Proteasome subunit-α type-6 protein is post-transcriptionally repressed by the microRNA-4490 in diabetic nephropathy. (PMID: 30287505) Feng Y … Wei L (Bioscience reports 2018) 3
  2. A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus. (PMID: 25130324) Cai DC … Hagoort P (Genes, brain, and behavior 2014) 3
  3. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4490 Gene

Sources for MIR4490 Gene