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Aliases for MIR4485 Gene

Subcategory (RNA class) for MIR4485 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4485 Gene

  • MicroRNA 4485 2 3 5
  • Hsa-Mir-4485 3
  • Mir-4485 3

External Ids for MIR4485 Gene

Previous GeneCards Identifiers for MIR4485 Gene

  • GC11U901877
  • GC11M010542
  • GC11M010549
  • GC11M010516
  • GC11M010523
  • GC11M010545
  • GC11M010557
  • GC11M010564
  • GC11M010569
  • GC11M010574

Summaries for MIR4485 Gene

Entrez Gene Summary for MIR4485 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4485 Gene

MIR4485 (MicroRNA 4485) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4485 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4485 Gene

Genomics for MIR4485 Gene

GeneHancer (GH) Regulatory Elements for MIR4485 Gene

Promoters and enhancers for MIR4485 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I010509 Promoter/Enhancer 0.9 EPDnew Ensembl ENCODE 550.8 -1.0 -975 1 GC11M010511 MTRNR2L8 PIR32636 MIR4485 PIR43375 MRVI1-AS1
GH11I010508 Promoter 0.5 EPDnew 550.8 -0.4 -378 0.1 GC11M010511 MTRNR2L8 PIR32636 MIR4485 PIR43375
GH11I010507 Enhancer 0.4 Ensembl ENCODE 550.8 +0.3 284 0.5 GC11M010511 MTRNR2L8 MIR4485 PIR43375 MRVI1-AS1 GC11M010474
GH11I010510 Enhancer 0.2 ENCODE 550.8 -1.9 -1923 0.2 GC11M010511 MTRNR2L8 PIR32636 MIR4485 PIR43375 GC11M010583
GH11I010512 Enhancer 0.2 ENCODE 550.8 -1.7 -1703 0.2 GC11M010511 MTRNR2L8 PIR32636 MIR4485 PIR43375 RNF141
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4485 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4485 Gene

Genomic Locations for MIR4485 Gene
chr11:10,508,270-10,508,326
(GRCh38/hg38)
Size:
57 bases
Orientation:
Minus strand
chr11:10,529,817-10,529,873
(GRCh37/hg19)

Genomic View for MIR4485 Gene

Genes around MIR4485 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4485 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4485 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4485 Gene

Proteins for MIR4485 Gene

Post-translational modifications for MIR4485 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4485 Gene

Domains & Families for MIR4485 Gene

Gene Families for MIR4485 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4485: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4485 Gene

Function for MIR4485 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4485 Gene

Localization for MIR4485 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4485 Gene

Pathways & Interactions for MIR4485 Gene

SuperPathways for MIR4485 Gene

No Data Available

Interacting Proteins for MIR4485 Gene

Gene Ontology (GO) - Biological Process for MIR4485 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4485 Gene

Drugs & Compounds for MIR4485 Gene

No Compound Related Data Available

Transcripts for MIR4485 Gene

mRNA/cDNA for MIR4485 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4485 Gene

No ASD Table

Relevant External Links for MIR4485 Gene

GeneLoc Exon Structure for
MIR4485
ECgene alternative splicing isoforms for
MIR4485

Expression for MIR4485 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4485 Gene:

MIR4485
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4485 Gene

Orthologs for MIR4485 Gene

Evolution for MIR4485 Gene

ENSEMBL:
Gene Tree for MIR4485 (if available)
TreeFam:
Gene Tree for MIR4485 (if available)

No data available for Orthologs for MIR4485 Gene

Paralogs for MIR4485 Gene

No data available for Paralogs for MIR4485 Gene

Variants for MIR4485 Gene

Sequence variations from dbSNP and Humsavar for MIR4485 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000344130 -- 10,508,381(-) C/A upstream_transcript_variant
rs1005664312 -- 10,510,101(-) T/C/G upstream_transcript_variant
rs1005695481 -- 10,509,858(-) G/C upstream_transcript_variant
rs1005813493 -- 10,507,833(-) T/C downstream_transcript_variant
rs1006030691 -- 10,508,796(-) C/G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4485 Gene

Variant ID Type Subtype PubMed ID
nsv975881 CNV duplication 23825009
nsv972946 CNV duplication 23825009
nsv1044011 CNV gain 25217958
esv3625358 CNV gain 21293372
esv22967 CNV gain 19812545

Additional Variant Information for MIR4485 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4485

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4485 Gene

Disorders for MIR4485 Gene

Additional Disease Information for MIR4485

No disorders were found for MIR4485 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4485 Gene

Publications for MIR4485 Gene

  1. Differential expression of microRNA in peripheral blood mononuclear cells as specific biomarker for major depressive disorder patients. (PMID: 25201637) Fan HM … Lu J (Journal of psychiatric research 2014) 3 58
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  3. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 58
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58
  5. hsa-miR-4485 regulates mitochondrial functions and inhibits the tumorigenicity of breast cancer cells. (PMID: 28220193) Sripada L … Singh R (Journal of molecular medicine (Berlin, Germany) 2017) 3

Products for MIR4485 Gene

Sources for MIR4485 Gene

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