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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR4481 (MicroRNA 4481) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4481 include Thiopurines, Poor Metabolism Of, 1.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH10J012656 | Enhancer | 0.8 | Ensembl ENCODE | 0.7 | -3.2 | -3159 | 1.1 | CTCF REST RAD21 ZNF501 TRIM22 ZNF140 CBX3 RUNX3 SMC3 EBF1 | SEPHS1 ENSG00000228302 ENSG00000239665 CAMK1D MIR548Q CCDC3 OPTN MIR4481 piR-57461-021 | |
GH10J012632 | Enhancer | 0.9 | Ensembl ENCODE | 0.4 | +20.8 | 20849 | 1.2 | SP1 ZNF341 FOXA2 YY1 PKNOX1 CHD1 JUND SIN3A SAP130 RAD21 | MIR548Q CAMK1D CCDC3 OPTN MIR4481 RF00017-588 | |
GH10J012603 | Enhancer | 1 | ENCODE dbSUPER | 0.3 | +48.0 | 47952 | 4.1 | HNRNPL GATAD2A REST POLR2A TARDBP FOXA1 RXRB SP1 GABPA CEBPA | MIR548Q RF00017-588 MIR4481 CAMK1D OPTN | |
GH10J012637 | Enhancer | 0.7 | Ensembl ENCODE | 0.4 | +15.7 | 15740 | 3.3 | TEAD4 ZIC2 ZNF600 ZNF341 ZBTB17 PRDM6 ZNF664 KLF1 | MIR548Q CAMK1D CCDC3 OPTN MIR4481 RF00017-588 | |
GH10J012628 | Enhancer | 0.7 | Ensembl ENCODE | 0.4 | +23.9 | 23896 | 1.8 | SP1 ATF3 YY1 HNF4A RXRA ELF1 ELF3 | MIR4481 RF00017-588 CAMK1D OPTN |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903561 | extracellular vesicle | HDA | 28798470 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075BEB1_9606 | precursor_RNA | 60 | 4 |
HGNC: 41781, RefSeq: NR_039701, Ensembl: ENST00000637781 (view in UCSC) , miRBase: MI0016842, |
URS0000759B99_9606 | miRNA | 17 | 2 |
RefSeq: NR_039701, miRBase: MIMAT0019015, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3622363 | CNV | gain | 21293372 |
nsv1041648 | CNV | gain | 25217958 |
nsv831786 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
thiopurines, poor metabolism of, 1 |
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