microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4481 Gene

Subcategory (RNA class) for MIR4481 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR4481 Gene

  • MicroRNA 4481 2 3 5
  • Hsa-Mir-4481 2 3
  • MIR4481 2 5
  • MIMAT0019015 50
  • MI0016842 50

External Ids for MIR4481 Gene

Previous GeneCards Identifiers for MIR4481 Gene

  • GC10U901561

Summaries for MIR4481 Gene

Entrez Gene Summary for MIR4481 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4481 Gene

MIR4481 (MicroRNA 4481) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4481 include Thiopurines, Poor Metabolism Of, 1.

Additional gene information for MIR4481 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4481 Gene

Genomics for MIR4481 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4481 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J012656 Enhancer 0.8 Ensembl ENCODE 0.7 -3.2 -3159 1.1 CTCF REST RAD21 ZNF501 TRIM22 ZNF140 CBX3 RUNX3 SMC3 EBF1 SEPHS1 ENSG00000228302 ENSG00000239665 CAMK1D MIR548Q CCDC3 OPTN MIR4481 piR-57461-021
GH10J012632 Enhancer 0.9 Ensembl ENCODE 0.4 +20.8 20849 1.2 SP1 ZNF341 FOXA2 YY1 PKNOX1 CHD1 JUND SIN3A SAP130 RAD21 MIR548Q CAMK1D CCDC3 OPTN MIR4481 RF00017-588
GH10J012603 Enhancer 1 ENCODE dbSUPER 0.3 +48.0 47952 4.1 HNRNPL GATAD2A REST POLR2A TARDBP FOXA1 RXRB SP1 GABPA CEBPA MIR548Q RF00017-588 MIR4481 CAMK1D OPTN
GH10J012637 Enhancer 0.7 Ensembl ENCODE 0.4 +15.7 15740 3.3 TEAD4 ZIC2 ZNF600 ZNF341 ZBTB17 PRDM6 ZNF664 KLF1 MIR548Q CAMK1D CCDC3 OPTN MIR4481 RF00017-588
GH10J012628 Enhancer 0.7 Ensembl ENCODE 0.4 +23.9 23896 1.8 SP1 ATF3 YY1 HNF4A RXRA ELF1 ELF3 MIR4481 RF00017-588 CAMK1D OPTN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4481 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4481 Gene

Genomic Locations for MIR4481 Gene
chr10:12,653,138-12,653,197
(GRCh38/hg38)
Size:
60 bases
Orientation:
Minus strand
chr10:12,695,137-12,695,196
(GRCh37/hg19)
Size:
60 bases
Orientation:
Minus strand

Genomic View for MIR4481 Gene

Genes around MIR4481 on UCSC Golden Path with GeneCards custom track
MIR4481 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4481 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4481 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4481 Gene

Proteins for MIR4481 Gene

Post-translational modifications for MIR4481 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4481 Gene

Domains & Families for MIR4481 Gene

Gene Families for MIR4481 Gene

HGNC:
genes like me logo Genes that share domains with MIR4481: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4481 Gene

Function for MIR4481 Gene

Phenotypes From GWAS Catalog for MIR4481 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4481 Gene

Localization for MIR4481 Gene

Gene Ontology (GO) - Cellular Components for MIR4481 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR4481: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR4481 Gene

Pathways & Interactions for MIR4481 Gene

PathCards logo

SuperPathways for MIR4481 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4481 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4481 Gene

Drugs & Compounds for MIR4481 Gene

No Compound Related Data Available

Transcripts for MIR4481 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4481 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075BEB1_9606 precursor_RNA 60 4

HGNC: 41781,

RefSeq: NR_039701,

Ensembl: ENST00000637781 (view in UCSC) ,

miRBase: MI0016842,

URS0000759B99_9606 miRNA 17 2

RefSeq: NR_039701,

miRBase: MIMAT0019015,

MIR4481 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4481 Gene

No ASD Table

Relevant External Links for MIR4481 Gene

GeneLoc Exon Structure for
MIR4481

No data available for mRNA/cDNA for MIR4481 Gene

Expression for MIR4481 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR4481

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4481 Gene

Orthologs for MIR4481 Gene

Evolution for MIR4481 Gene

ENSEMBL:
Gene Tree for MIR4481 (if available)
TreeFam:
Gene Tree for MIR4481 (if available)

No data available for Orthologs for MIR4481 Gene

Paralogs for MIR4481 Gene

No data available for Paralogs for MIR4481 Gene

Variants for MIR4481 Gene

Additional dbSNP identifiers (rs#s) for MIR4481 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4481 Gene

Variant ID Type Subtype PubMed ID
esv3622363 CNV gain 21293372
nsv1041648 CNV gain 25217958
nsv831786 CNV loss 17160897

Additional Variant Information for MIR4481 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4481

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4481 Gene

Disorders for MIR4481 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR4481 Gene - From: DISEASES

Disorder Aliases PubMed IDs
thiopurines, poor metabolism of, 1
  • thpm1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR4481

genes like me logo Genes that share disorders with MIR4481: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR4481 Gene

Publications for MIR4481 Gene

  1. Identification of the novel 3' UTR sequences of human IL-21 mRNA as potential targets of miRNAs. (PMID: 28798470) Enomoto Y … Miyajima A (Scientific reports 2017) 3
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4481 Gene

Sources for MIR4481 Gene