Free for academic non-profit institutions. Other users need a Commercial license
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR4481 Gene
Data sources for MIR4481 Gene:
Subcategory (RNA class) for MIR4481 Gene
miRNA
Aliases for MIR4481 Gene
- MicroRNA 4481 (HGNC, NCBI Entrez Gene, Ensembl)
- Hsa-Mir-4481 (HGNC, NCBI Entrez Gene)
- MIMAT0019015 (miRBase)
- MI0016842 (miRBase)
- MIR4481 (Ensembl)
External Ids for MIR4481 Gene
- HGNC: 41781
- NCBI Entrez Gene: 100616320
- Ensembl: ENSG00000283699
- miRBase: hsa-mir-4481
Previous GeneCards Identifiers for MIR4481 Gene
- GC10U901561
Summaries for MIR4481 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR4481 Gene
MIR4481 (MicroRNA 4481) is an RNA Gene, and is affiliated with the miRNA class.
Additional gene information for MIR4481 Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4481 Gene
Genomics for MIR4481 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR4481 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH10J012656 | Enhancer | 0.8 | Ensembl ENCODE | 0.7 | -3.2 | -3159 | 1.1 | CTCF REST TRIM22 EBF1 SMC3 RAD21 ZNF140 TRIM28 ZSCAN21 KLF16 | SEPHS1 ENSG00000228302 ENSG00000239665 CAMK1D MIR548Q CCDC3 OPTN MIR4481 piR-57461-021 | |
| GH10J012632 | Enhancer | 0.9 | Ensembl ENCODE | 0.3 | +20.8 | 20849 | 1.2 | FOXA2 SAP130 ZNF341 RXRA JUND FOXA1 HMG20A HNF4A PKNOX1 ZNF48 | MIR548Q CAMK1D CCDC3 OPTN MIR4481 RF00017-588 | |
| GH10J012603 | Enhancer | 1 | ENCODE dbSUPER | 0.3 | +48.0 | 47952 | 4.1 | CEBPA ZNF217 POLR2A ELF1 MBD2 CUX1 FOXA2 SAP130 RXRA ZBTB33 | MIR548Q RF00017-588 MIR4481 CAMK1D OPTN | |
| GH10J012637 | Enhancer | 0.6 | Ensembl ENCODE | 0.4 | +15.4 | 15440 | 2.7 | ZIC2 ZNF341 ZNF664 KLF1 ZBTB17 ZNF600 | MIR548Q CAMK1D CCDC3 OPTN MIR4481 RF00017-588 | |
| GH10J012628 | Enhancer | 0.7 | Ensembl ENCODE | 0.3 | +23.9 | 23896 | 1.4 | RXRA HNF4A ELF3 SP1 ELF1 ATF3 YY1 | MIR4481 RF00017-588 CAMK1D OPTN |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR4481 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR4481 Gene
Latest Assembly
- chr10:12,653,138-12,653,197
- (GRCh38/hg38)
- Size:
- 60 bases
- Orientation:
- Minus strand
Previous Assembly
- chr10:12,695,137-12,695,196
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 60 bases
- Orientation:
- Minus strand
Genomic View for MIR4481 Gene
Genes around MIR4481 on UCSC Golden Path with GeneCards custom track
MIR4481 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 10p13 by HGNC
- 10p13 by Entrez Gene
- 10p13 by Ensembl
MIR4481 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR4481 Gene
Proteins for MIR4481 Gene
Post-translational modifications for MIR4481 Gene
No Post-translational modifications
No data available for DME Specific Peptides for MIR4481 Gene
Domains & Families for MIR4481 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4481 Gene
Function for MIR4481 Gene
Phenotypes From GWAS Catalog for MIR4481 Gene
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR4481 - Starting at $85 >
- * MIR4481 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR4481 - Starting at $45 >
- * MIR4481 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4481 Gene
Localization for MIR4481 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:1903561 | extracellular vesicle | HDA | 28798470 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR4481 Gene
Transcripts for MIR4481 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4481 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS000075BEB1_9606 | precursor_RNA | 60 | 3 |
RefSeq: NR_039701, Ensembl: ENST00000637781 (view in UCSC) , miRBase: MI0016842, |
| URS0000759B99_9606 | miRNA | 17 | 2 |
RefSeq: NR_039701, miRBase: MIMAT0019015, |
MIR4481 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR4481 - Starting at $85 >
- * MIR4481 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR4481 - Starting at $45 >
- * MIR4481 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for MIR4481 Gene
- GeneLoc Exon Structure for
- MIR4481
No data available for mRNA/cDNA for MIR4481 Gene
Expression for MIR4481 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR4481
No Expression Related Data Available
Gene Expression Assays for research
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4481 Gene
Orthologs for MIR4481 Gene
No data available for Orthologs for MIR4481 Gene
Paralogs for MIR4481 Gene
No data available for Paralogs for MIR4481 Gene
Variants for MIR4481 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3622363 | CNV | gain | 21293372 |
| nsv1041648 | CNV | gain | 25217958 |
| nsv831786 | CNV | loss | 17160897 |
Additional Variant Information for MIR4481 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR4481
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4481 Gene
Disorders for MIR4481 Gene
Additional Disease Information for MIR4481
No disorders were found for MIR4481 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4481 Gene
Publications for MIR4481 Gene
- Identification of the novel 3' UTR sequences of human IL-21 mRNA as potential targets of miRNAs. (PMID: 28798470) Enomoto Y … Miyajima A (Scientific reports 2017) 3
- Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
- miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3
ExternalLinks
Products for MIR4481 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR4481
- Origene Custom Protein Services for MIR4481
- Browse OriGene Inhibitory RNA Products For MIR4481
- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for MIR4481
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR4481
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR4481
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR4481
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR4481
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR4481
Sources for MIR4481 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB