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Aliases for MIR448 Gene

Subcategory (RNA class) for MIR448 Gene


Quality Score for this RNA gene is


Aliases for MIR448 Gene

  • MicroRNA 448 2 3 5
  • Hsa-Mir-448 3
  • MiRNA448 3
  • MIRN448 3

External Ids for MIR448 Gene

ORGUL Members for MIR448 Gene

Previous HGNC Symbols for MIR448 Gene

  • MIRN448

Previous GeneCards Identifiers for MIR448 Gene

  • GC0XP113964
  • GC0XP114058

Summaries for MIR448 Gene

Entrez Gene Summary for MIR448 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR448 Gene

MIR448 (MicroRNA 448) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR448 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR448 Gene

Genomics for MIR448 Gene

Genomic Locations for MIR448 Gene

Genomic Locations for MIR448 Gene
111 bases
Plus strand

Genomic View for MIR448 Gene

Genes around MIR448 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR448 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR448 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR448 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR448 Gene

Proteins for MIR448 Gene

Post-translational modifications for MIR448 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR448 Gene

Domains & Families for MIR448 Gene

Gene Families for MIR448 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR448: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR448 Gene

Function for MIR448 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR448 Gene

Localization for MIR448 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR448 Gene

Pathways & Interactions for MIR448 Gene

SuperPathways for MIR448 Gene

No Data Available

Interacting Proteins for MIR448 Gene

Gene Ontology (GO) - Biological Process for MIR448 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR448 Gene

Drugs & Compounds for MIR448 Gene

No Compound Related Data Available

Transcripts for MIR448 Gene

mRNA/cDNA for MIR448 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR448 Gene

No ASD Table

Relevant External Links for MIR448 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR448 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR448 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR448 Gene

Orthologs for MIR448 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR448 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-448 34
  • 100 (a)
(Canis familiaris)
Mammalia cfa-mir-448 34
  • 93 (a)
(Mus musculus)
Mammalia Mir448 34
  • 90 (a)
(Bos Taurus)
Mammalia bta-mir-448 34
  • 89 (a)
Species where no ortholog for MIR448 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR448 Gene

Gene Tree for MIR448 (if available)
Gene Tree for MIR448 (if available)

Paralogs for MIR448 Gene

No data available for Paralogs for MIR448 Gene

Variants for MIR448 Gene

Sequence variations from dbSNP and Humsavar for MIR448 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1003735053 -- 114,823,165(+) A/G upstream_transcript_variant
rs1004995418 -- 114,823,751(+) G/A downstream_transcript_variant
rs1008720353 -- 114,822,017(+) T/C/G upstream_transcript_variant
rs1009545031 -- 114,823,145(+) C/G upstream_transcript_variant
rs1010242856 -- 114,822,454(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR448 Gene

Variant ID Type Subtype PubMed ID
esv33994 CNV gain+loss 17666407
nsv527347 CNV gain 19592680

Additional Variant Information for MIR448 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR448 Gene

Disorders for MIR448 Gene

Additional Disease Information for MIR448

No disorders were found for MIR448 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR448 Gene

Publications for MIR448 Gene

  1. MicroRNA-448 promotes multiple sclerosis development through induction of Th17 response through targeting protein tyrosine phosphatase non-receptor type 2 (PTPN2). (PMID: 28342869) Wu R … Bi X (Biochemical and biophysical research communications 2017) 3 58
  2. MicroRNA-448 suppresses osteosarcoma cell proliferation and invasion through targeting EPHA7. (PMID: 28604772) Wu X … Ding X (PloS one 2017) 3 58
  3. Application of plasma circulating microRNA-448, 506, 4316, and 4478 analysis for non-invasive diagnosis of lung cancer. (PMID: 26341493) Powrózek T … Milanowski J (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 58
  4. microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia. (PMID: 26882564) Correia NC … Barata JT (Oncotarget 2016) 3 58
  5. Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448. (PMID: 26917489) Bamodu OA … Chao TY (BMC cancer 2016) 3 58

Products for MIR448 Gene

Sources for MIR448 Gene

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