microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4469 Gene

Data sources for MIR4469 Gene:

RNA type for MIR4469 Gene

miRNA

Aliases for MIR4469 Gene

External Ids for MIR4469 Gene

Previous GeneCards Identifiers for MIR4469 Gene

  • GC08U901572
  • GC08M042753
  • GC08M042849

Summaries for MIR4469 Gene

Entrez Gene Summary for MIR4469 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4469 Gene

MIR4469 (MicroRNA 4469) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4469 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4469 Gene

Genomics for MIR4469 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4469 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J042893 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 250.7 +0.1 67 6.4 BCLAF1 ZNF207 MYC ZNF600 KLF9 ZSCAN16 NFIC POLR2A ZIC2 YY1 THAP1 HOOK3 MIR4469 RNF170 FNTA SNODB2080 MN298114-252 RF00017-6459
GH08J042890 Enhancer 0.6 ENCODE 0.7 +4.0 3969 0.4 EBF1 STAT5A IKZF1 MTA3 ATF2 ZNF217 PKNOX1 IKZF2 DPF2 RELB HE855963 SNODB2080 MK992670 THAP1 HOOK3 MIR4469 RNF170 MN298114-252 RF00017-6459
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4469 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4469 Gene

Latest Assembly
chr8:42,896,197-42,896,275
(GRCh38/hg38)
Size:
79 bases
Orientation:
Minus strand

Previous Assembly
chr8:42,751,340-42,751,418
(GRCh37/hg19 by Entrez Gene)
Size:
79 bases
Orientation:
Minus strand

Genomic View for MIR4469 Gene

Genes around MIR4469 on UCSC Golden Path with GeneCards custom track
MIR4469 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR4469 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4469 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4469 Gene

Proteins for MIR4469 Gene

Post-translational modifications for MIR4469 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4469 Gene

Domains & Families for MIR4469 Gene

Gene Families for MIR4469 Gene

HGNC:
genes like me logo Genes that share domains with MIR4469: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4469 Gene

Function for MIR4469 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4469 Gene

Localization for MIR4469 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4469 Gene

Pathways & Interactions for MIR4469 Gene

PathCards logo

SuperPathways for MIR4469 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4469 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4469 Gene

Drugs & Compounds for MIR4469 Gene

No Compound Related Data Available

Transcripts for MIR4469 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4469 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000075ABE0_9606 precursor_RNA 79 4

RefSeq: NR_039679,

Ensembl: ENST00000583919 (view in UCSC) ,

miRBase: MI0016820,

ENA: LM611315.1:1..79:precursor_RNA,

URS00002CEB74_9606 miRNA 22 3

RefSeq: NR_039679,

miRBase: MIMAT0018996,

ENA: FR772839.1:1..22:ncRNA, LM382407.1:1..22:ncRNA, LM611315.1:52..73:ncRNA,

MIR4469 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR4469 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4469 Gene

No ASD Table

Relevant External Links for MIR4469 Gene

GeneLoc Exon Structure for
MIR4469

Expression for MIR4469 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4469 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR4469

genes like me logo Genes that share expression patterns with MIR4469: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4469 Gene

Orthologs for MIR4469 Gene

Evolution for MIR4469 Gene

ENSEMBL:
Gene Tree for MIR4469 (if available)
TreeFam:
Gene Tree for MIR4469 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR4469

No data available for Orthologs for MIR4469 Gene

Paralogs for MIR4469 Gene

No data available for Paralogs for MIR4469 Gene

Variants for MIR4469 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR4469 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for MIR4469 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4469
Leiden Open Variation Database (LOVD)
MIR4469

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR4469 Gene

Disorders for MIR4469 Gene

Additional Disease Information for MIR4469

No disorders were found for MIR4469 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4469 Gene

Publications for MIR4469 Gene

  1. LncRNA HCG11 suppresses laryngeal carcinoma cells progression via sponging miR-4469/APOM axis. (PMID: 32271435) Xue HX … Bian WC (European review for medical and pharmacological sciences 2020) 3
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  3. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  4. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4469 Gene

Sources for MIR4469 Gene