microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4465 Gene

Subcategory (RNA class) for MIR4465 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR4465 Gene

  • MicroRNA 4465 2 3 5
  • Hsa-Mir-4465 2 3
  • MIR4465 2 5
  • MIMAT0018992 50
  • MI0016816 50

External Ids for MIR4465 Gene

Previous GeneCards Identifiers for MIR4465 Gene

  • GC06U902219
  • GC06P141006

Summaries for MIR4465 Gene

Entrez Gene Summary for MIR4465 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4465 Gene

MIR4465 (MicroRNA 4465) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4465 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4465 Gene

Genomics for MIR4465 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4465 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J140684 Enhancer 0.3 Ensembl 600.7 +1.3 1287 0.6 NFE2 L3MBTL2 MIR4465 piR-60031-056 LOC105378027 ENSG00000285875
GH06J140669 Enhancer 0.3 Ensembl 0.4 -13.9 -13913 1 RUNX3 SPI1 RPS3AP24 ENSG00000234147 LOC105378026 MIR4465 LOC105378027 ENSG00000285875
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4465 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4465 Gene

Genomic Locations for MIR4465 Gene
chr6:140,683,814-140,683,883
(GRCh38/hg38)
Size:
70 bases
Orientation:
Plus strand
chr6:141,004,951-141,005,020
(GRCh37/hg19)
Size:
70 bases
Orientation:
Plus strand

Genomic View for MIR4465 Gene

Genes around MIR4465 on UCSC Golden Path with GeneCards custom track
MIR4465 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4465 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4465 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4465 Gene

Proteins for MIR4465 Gene

Post-translational modifications for MIR4465 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4465 Gene

Domains & Families for MIR4465 Gene

Gene Families for MIR4465 Gene

HGNC:
genes like me logo Genes that share domains with MIR4465: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4465 Gene

Function for MIR4465 Gene

Phenotypes From GWAS Catalog for MIR4465 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4465 Gene

Localization for MIR4465 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4465 Gene

Pathways & Interactions for MIR4465 Gene

PathCards logo

SuperPathways for MIR4465 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4465 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4465 Gene

Drugs & Compounds for MIR4465 Gene

No Compound Related Data Available

Transcripts for MIR4465 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4465 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075EA2C_9606 precursor_RNA 70 4

HGNC: 41842,

RefSeq: NR_039675,

Ensembl: ENST00000583434 (view in UCSC) ,

miRBase: MI0016816,

URS000075D297_9606 miRNA 22 2

RefSeq: NR_039675,

miRBase: MIMAT0018992,

MIR4465 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4465 Gene

No ASD Table

Relevant External Links for MIR4465 Gene

GeneLoc Exon Structure for
MIR4465

No data available for mRNA/cDNA for MIR4465 Gene

Expression for MIR4465 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4465 Gene

genes like me logo Genes that share expression patterns with MIR4465: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4465 Gene

Orthologs for MIR4465 Gene

Evolution for MIR4465 Gene

ENSEMBL:
Gene Tree for MIR4465 (if available)
TreeFam:
Gene Tree for MIR4465 (if available)

No data available for Orthologs for MIR4465 Gene

Paralogs for MIR4465 Gene

No data available for Paralogs for MIR4465 Gene

Variants for MIR4465 Gene

Additional dbSNP identifiers (rs#s) for MIR4465 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4465 Gene

Variant ID Type Subtype PubMed ID
esv2614350 CNV loss 19546169
esv2761069 CNV loss 21179565
esv2763598 CNV gain 21179565
esv33208 CNV loss 17666407
esv3576233 CNV gain 25503493
esv3890953 CNV loss 25118596
nsv1023213 CNV gain 25217958
nsv1026042 CNV gain 25217958
nsv604765 CNV gain 21841781
nsv604774 CNV loss 21841781
nsv604775 CNV loss 21841781
nsv604777 CNV loss 21841781
nsv830821 CNV loss 17160897

Additional Variant Information for MIR4465 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4465

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4465 Gene

Disorders for MIR4465 Gene

Additional Disease Information for MIR4465

No disorders were found for MIR4465 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4465 Gene

Publications for MIR4465 Gene

  1. MiR-4465 directly targets PTEN to inhibit AKT/mTOR pathway-mediated autophagy. (PMID: 30421325) Tao Z … Wang M (Cell stress & chaperones 2019) 3
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4465 Gene

Sources for MIR4465 Gene