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Aliases for MIR4456 Gene

Subcategory (RNA class) for MIR4456 Gene


Quality Score for this RNA gene is


Aliases for MIR4456 Gene

  • MicroRNA 4456 2 3 5
  • Hsa-Mir-4456 3

External Ids for MIR4456 Gene

Previous GeneCards Identifiers for MIR4456 Gene

  • GC05U901577

Summaries for MIR4456 Gene

Entrez Gene Summary for MIR4456 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4456 Gene

MIR4456 (MicroRNA 4456) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4456 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4456 Gene

Genomics for MIR4456 Gene

GeneHancer (GH) Regulatory Elements for MIR4456 Gene

Promoters and enhancers for MIR4456 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I000535 Enhancer 0.3 dbSUPER 550.8 +0.4 372 0.6 GLIS2 MIR4456 SLC9A3 EXOC3 SLC9A3-AS1 ENSG00000250385
GH05I000532 Enhancer 0.6 dbSUPER 0.8 +3.0 2954 1.3 SOX13 GATAD2A TFAP4 FOXA2 ARID4B MNT ZBTB7B PPARG MXD3 CEP72 AHRR SLC6A3 MIR4456 ENSG00000250385 SLC9A3
GH05I000529 Enhancer 0.9 Ensembl ENCODE 0.4 +5.5 5481 1.2 NEUROD1 E2F1 CTBP1 GATA3 ARID3A ATF7 RCOR1 RUNX3 HES1 EZH2 CEP72 ENSG00000250385 MIR4456 SLC9A3
GH05I000528 Enhancer 0.5 dbSUPER 0.4 +7.3 7302 0.8 SUZ12 MAX MYC EZH2 SLC9A3 SLC6A3 ENSG00000250385 MIR4456
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4456 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4456 Gene

Genomic Locations for MIR4456 Gene
43 bases
Minus strand

Genomic View for MIR4456 Gene

Genes around MIR4456 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4456 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4456 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4456 Gene

Proteins for MIR4456 Gene

Post-translational modifications for MIR4456 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4456 Gene

Domains & Families for MIR4456 Gene

Gene Families for MIR4456 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4456: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4456 Gene

Function for MIR4456 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4456 Gene

Localization for MIR4456 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4456 Gene

Pathways & Interactions for MIR4456 Gene

SuperPathways for MIR4456 Gene

No Data Available

Interacting Proteins for MIR4456 Gene

Gene Ontology (GO) - Biological Process for MIR4456 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR4456 Gene

Drugs & Compounds for MIR4456 Gene

No Compound Related Data Available

Transcripts for MIR4456 Gene

mRNA/cDNA for MIR4456 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4456 Gene

No ASD Table

Relevant External Links for MIR4456 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4456 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4456 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4456 Gene

Orthologs for MIR4456 Gene

Evolution for MIR4456 Gene

Gene Tree for MIR4456 (if available)
Gene Tree for MIR4456 (if available)

No data available for Orthologs for MIR4456 Gene

Paralogs for MIR4456 Gene

No data available for Paralogs for MIR4456 Gene

Variants for MIR4456 Gene

Sequence variations from dbSNP and Humsavar for MIR4456 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1001791894 -- 535,486(-) C/T downstream_transcript_variant
rs1002067192 -- 537,513(-) C/T upstream_transcript_variant
rs1002663816 -- 536,338(-) G/A upstream_transcript_variant
rs1003144239 -- 536,217(-) A/G upstream_transcript_variant
rs1003266335 -- 537,567(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4456 Gene

Variant ID Type Subtype PubMed ID
dgv9479n54 CNV gain 21841781
esv2752071 CNV gain 17911159
esv2759315 CNV loss 17122850
esv3603750 CNV gain 21293372
esv3603754 CNV gain 21293372
esv3894107 CNV gain 25118596
nsv1019215 CNV gain 25217958
nsv1032584 CNV gain 25217958
nsv1133013 OTHER inversion 24896259
nsv1147234 OTHER inversion 26484159
nsv461889 CNV gain 19166990
nsv461890 CNV gain 19166990
nsv509042 CNV insertion 20534489
nsv596626 CNV gain 21841781
nsv596628 CNV gain 21841781
nsv596629 CNV gain 21841781
nsv822926 CNV gain 20364138
nsv950619 CNV deletion 24416366

Additional Variant Information for MIR4456 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4456 Gene

Disorders for MIR4456 Gene

Additional Disease Information for MIR4456

No disorders were found for MIR4456 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4456 Gene

Publications for MIR4456 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 58
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4456 Gene

Sources for MIR4456 Gene

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