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Aliases for MIR4454 Gene

Subcategory (RNA class) for MIR4454 Gene


Quality Score for this RNA gene is


Aliases for MIR4454 Gene

  • MicroRNA 4454 2 3 5
  • Hsa-Mir-4454 3

External Ids for MIR4454 Gene

Previous GeneCards Identifiers for MIR4454 Gene

  • GC04U901515
  • GC04M164016

Summaries for MIR4454 Gene

Entrez Gene Summary for MIR4454 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4454 Gene

MIR4454 (MicroRNA 4454) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4454 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4454 Gene

Genomics for MIR4454 Gene

GeneHancer (GH) Regulatory Elements for MIR4454 Gene

Promoters and enhancers for MIR4454 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I163063 Enhancer 0.5 ENCODE 0.3 +29.6 29564 0.2 JUND GFI1B FOSL2 FOS LOC101928081 MIR4454 ENSG00000251123
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4454 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4454 Gene

Genomic Locations for MIR4454 Gene
55 bases
Minus strand

Genomic View for MIR4454 Gene

Genes around MIR4454 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4454 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4454 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4454 Gene

Proteins for MIR4454 Gene

Post-translational modifications for MIR4454 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4454 Gene

Domains & Families for MIR4454 Gene

Gene Families for MIR4454 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4454: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4454 Gene

Function for MIR4454 Gene

Phenotypes From GWAS Catalog for MIR4454 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4454 Gene

Localization for MIR4454 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4454 Gene

Pathways & Interactions for MIR4454 Gene

SuperPathways for MIR4454 Gene

No Data Available

Interacting Proteins for MIR4454 Gene

Gene Ontology (GO) - Biological Process for MIR4454 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR4454 Gene

Drugs & Compounds for MIR4454 Gene

No Compound Related Data Available

Transcripts for MIR4454 Gene

mRNA/cDNA for MIR4454 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4454 Gene

No ASD Table

Relevant External Links for MIR4454 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4454 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4454 Gene

mRNA differential expression in normal tissues according to GTEx for MIR4454 Gene

This gene is overexpressed in Breast - Mammary Tissue (x10.4), Esophagus - Mucosa (x8.5), Vagina (x5.9), Minor Salivary Gland (x5.5), and Skin - Sun Exposed (Lower leg) (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of MIR4454 Gene:

genes like me logo Genes that share expression patterns with MIR4454: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4454 Gene

Orthologs for MIR4454 Gene

Evolution for MIR4454 Gene

Gene Tree for MIR4454 (if available)
Gene Tree for MIR4454 (if available)

No data available for Orthologs for MIR4454 Gene

Paralogs for MIR4454 Gene

No data available for Paralogs for MIR4454 Gene

Variants for MIR4454 Gene

Sequence variations from dbSNP and Humsavar for MIR4454 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000988042 -- 163,093,468(-) A/G downstream_transcript_variant
rs1001347156 -- 163,093,755(-) GCG/G upstream_transcript_variant
rs1002024624 -- 163,093,826(-) G/A upstream_transcript_variant
rs1002158821 -- 163,094,042(-) C/T upstream_transcript_variant
rs1003744283 -- 163,095,214(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4454 Gene

Variant ID Type Subtype PubMed ID
dgv5571n100 CNV loss 25217958
dgv691n27 CNV loss 19166990
esv1001030 CNV gain 20482838
esv22341 CNV gain+loss 19812545
esv3569988 CNV loss 25503493
esv3576050 CNV gain 25503493
esv3602948 CNV gain 21293372
esv3602952 CNV loss 21293372
esv3604044 CNV loss 21293372
esv3606878 CNV loss 21293372
esv3894064 CNV gain 25118596
esv3894131 CNV gain 25118596
nsv1015505 CNV gain 25217958
nsv1018954 CNV loss 25217958
nsv1030184 CNV loss 25217958
nsv1034539 CNV loss 25217958
nsv1042376 CNV gain 25217958
nsv1047309 CNV gain 25217958
nsv428463 CNV loss 18775914
nsv4584 CNV insertion 18451855
nsv461978 CNV loss 19166990
nsv4703 CNV insertion 18451855
nsv509053 CNV insertion 20534489
nsv510896 OTHER complex 20534489
nsv517486 CNV gain+loss 19592680
nsv520673 CNV loss 19592680
nsv526392 CNV gain 19592680
nsv549299 CNV gain 21841781
nsv597157 CNV loss 21841781
nsv597158 CNV loss 21841781
nsv597159 CNV loss 21841781
nsv597160 CNV loss 21841781
nsv7198 OTHER inversion 18451855
nsv823004 CNV gain 20364138
nsv830206 CNV gain 17160897

Additional Variant Information for MIR4454 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4454 Gene

Disorders for MIR4454 Gene

Additional Disease Information for MIR4454

No disorders were found for MIR4454 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4454 Gene

Publications for MIR4454 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 58
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4454 Gene

Sources for MIR4454 Gene

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