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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR4452 Gene
Data sources for MIR4452 Gene:
Subcategory (RNA class) for MIR4452 Gene
miRNA
Aliases for MIR4452 Gene
- MicroRNA 4452 (HGNC, NCBI Entrez Gene, Ensembl)
- Hsa-Mir-4452 (HGNC, NCBI Entrez Gene)
- Hsa-MiR-4452 (LncBase, TarBase)
- MIMAT0018974 (miRBase)
- MI0016798 (miRBase)
- MIR4452 (Ensembl)
External Ids for MIR4452 Gene
- HGNC: 41539
- NCBI Entrez Gene: 100616463
- Ensembl: ENSG00000266515
- miRBase: hsa-mir-4452
Previous GeneCards Identifiers for MIR4452 Gene
- GC04U901495
- GC04M087464
Summaries for MIR4452 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR4452 Gene
MIR4452 (MicroRNA 4452) is an RNA Gene, and is affiliated with the miRNA class.
Additional gene information for MIR4452 Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4452 Gene
Genomics for MIR4452 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR4452 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH04J086540 | Enhancer | 0.8 | Ensembl ENCODE | 250.7 | -0.6 | -649 | 4.8 | IRF4 JUND PRDM6 BATF MAFK NFATC1 ATF2 JUNB ATF7 CREM | MIR4452 PTPN13 MAPK10 SLC10A6 HSD17B13 piR-39098-176 HSALNG0035662 lnc-SLC10A6-4 | |
| GH04J086521 | Enhancer | 0.6 | Ensembl | 0.4 | +19.9 | 19851 | 3.4 | CTCF EBF1 RAD21 SMC3 ELF1 IKZF1 NR2F1 IKZF2 EED TCF12 | PTPN13 MAPK10 SLC10A6 HSD17B13 HSALNG0035662 MIR4452 lnc-SLC10A6-4 | |
| GH04J086514 | Enhancer | 0.2 | Ensembl | 0.3 | +27.9 | 27851 | 0.2 | SLC10A6 HSALNG0035662 MIR4452 MAPK10 PTPN13 lnc-SLC10A6-4 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR4452 on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR4452 Gene
Latest Assembly
- chr4:86,542,482-86,542,552
- (GRCh38/hg38)
- Size:
- 71 bases
- Orientation:
- Minus strand
Previous Assembly
- chr4:87,463,635-87,463,705
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 71 bases
- Orientation:
- Minus strand
- chr4:87,463,635-87,463,705
- (GRCh37/hg19 by Ensembl)
- Size:
- 71 bases
- Orientation:
- Minus strand
Genomic View for MIR4452 Gene
Genes around MIR4452 on UCSC Golden Path with GeneCards custom track
MIR4452 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 4q21.3 by HGNC
- 4q21.3 by Entrez Gene
- 4q21.3 by Ensembl
MIR4452 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR4452 Gene
Proteins for MIR4452 Gene
Post-translational modifications for MIR4452 Gene
No Post-translational modifications
No data available for DME Specific Peptides for MIR4452 Gene
Domains & Families for MIR4452 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4452 Gene
Function for MIR4452 Gene
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR4452 - Starting at $85 >
- * MIR4452 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR4452 - Starting at $45 >
- * MIR4452 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4452 Gene
Localization for MIR4452 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4452 Gene
Transcripts for MIR4452 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4452 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS000075A9FF_9606 | miRNA | 23 | 4 |
RefSeq: NR_039657, LncBase: hsa-miR-4452, miRBase: MIMAT0018974, TarBase: hsa-miR-4452, |
| URS000075B8FF_9606 | precursor_RNA | 71 | 3 |
RefSeq: NR_039657, Ensembl: ENST00000583004 (view in UCSC) , miRBase: MI0016798, |
MIR4452 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR4452 - Starting at $85 >
- * MIR4452 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR4452 - Starting at $45 >
- * MIR4452 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for MIR4452 Gene
- GeneLoc Exon Structure for
- MIR4452
No data available for mRNA/cDNA for MIR4452 Gene
Expression for MIR4452 Gene
No Expression Related Data Available
Primer products for research
-
OriGene qPCR primer pairs for MIR4452
Gene Expression Assays for research
No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4452 Gene
Orthologs for MIR4452 Gene
No data available for Orthologs for MIR4452 Gene
Paralogs for MIR4452 Gene
No data available for Paralogs for MIR4452 Gene
Variants for MIR4452 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Additional Variant Information for MIR4452 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR4452
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4452 Gene
Disorders for MIR4452 Gene
Additional Disease Information for MIR4452
No disorders were found for MIR4452 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4452 Gene
Publications for MIR4452 Gene
- Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
- miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3
ExternalLinks
Products for MIR4452 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR4452
- Origene Custom Protein Services for MIR4452
- Browse OriGene Inhibitory RNA Products For MIR4452
- OriGene qPCR primer pairs for MIR4452
- Browse CRISPR knockouts for MIR4452
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR4452
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR4452
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR4452
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR4452
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR4452
Sources for MIR4452 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB