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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR4452 (MicroRNA 4452) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH04J086540 | Enhancer | 0.8 | Ensembl ENCODE | 250.7 | -0.6 | -649 | 4.8 | IRF4 JUND PRDM6 BATF MAFK NFATC1 ATF2 JUNB ATF7 CREM | MIR4452 PTPN13 MAPK10 SLC10A6 HSD17B13 piR-39098-176 HSALNG0035662 lnc-SLC10A6-4 | |
GH04J086521 | Enhancer | 0.6 | Ensembl | 0.4 | +19.9 | 19851 | 3.4 | CTCF EBF1 RAD21 SMC3 ELF1 IKZF1 NR2F1 IKZF2 EED TCF12 | PTPN13 MAPK10 SLC10A6 HSD17B13 HSALNG0035662 MIR4452 lnc-SLC10A6-4 | |
GH04J086514 | Enhancer | 0.2 | Ensembl | 0.3 | +27.9 | 27851 | 0.2 | SLC10A6 HSALNG0035662 MIR4452 MAPK10 PTPN13 lnc-SLC10A6-4 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075A9FF_9606 | miRNA | 23 | 4 |
RefSeq: NR_039657, LncBase: hsa-miR-4452, miRBase: MIMAT0018974, TarBase: hsa-miR-4452, |
URS000075B8FF_9606 | precursor_RNA | 71 | 3 |
RefSeq: NR_039657, Ensembl: ENST00000583004 (view in UCSC) , miRBase: MI0016798, |
No disorders were found for MIR4452 Gene.