microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4452 Gene

Data sources for MIR4452 Gene:

Subcategory (RNA class) for MIR4452 Gene

miRNA

Aliases for MIR4452 Gene

External Ids for MIR4452 Gene

Previous GeneCards Identifiers for MIR4452 Gene

  • GC04U901495
  • GC04M087464

Summaries for MIR4452 Gene

Entrez Gene Summary for MIR4452 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4452 Gene

MIR4452 (MicroRNA 4452) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4452 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4452 Gene

Genomics for MIR4452 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4452 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J086540 Enhancer 0.8 Ensembl ENCODE 250.7 -0.6 -649 4.8 IRF4 JUND PRDM6 BATF MAFK NFATC1 ATF2 JUNB ATF7 CREM MIR4452 PTPN13 MAPK10 SLC10A6 HSD17B13 piR-39098-176 HSALNG0035662 lnc-SLC10A6-4
GH04J086521 Enhancer 0.6 Ensembl 0.4 +19.9 19851 3.4 CTCF EBF1 RAD21 SMC3 ELF1 IKZF1 NR2F1 IKZF2 EED TCF12 PTPN13 MAPK10 SLC10A6 HSD17B13 HSALNG0035662 MIR4452 lnc-SLC10A6-4
GH04J086514 Enhancer 0.2 Ensembl 0.3 +27.9 27851 0.2 SLC10A6 HSALNG0035662 MIR4452 MAPK10 PTPN13 lnc-SLC10A6-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4452 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4452 Gene

Latest Assembly
chr4:86,542,482-86,542,552
(GRCh38/hg38)
Size:
71 bases
Orientation:
Minus strand

Previous Assembly
chr4:87,463,635-87,463,705
(GRCh37/hg19 by Entrez Gene)
Size:
71 bases
Orientation:
Minus strand

chr4:87,463,635-87,463,705
(GRCh37/hg19 by Ensembl)
Size:
71 bases
Orientation:
Minus strand

Genomic View for MIR4452 Gene

Genes around MIR4452 on UCSC Golden Path with GeneCards custom track
MIR4452 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR4452 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4452 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4452 Gene

Proteins for MIR4452 Gene

Post-translational modifications for MIR4452 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4452 Gene

Domains & Families for MIR4452 Gene

Gene Families for MIR4452 Gene

HGNC:
genes like me logo Genes that share domains with MIR4452: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4452 Gene

Function for MIR4452 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4452 Gene

Localization for MIR4452 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4452 Gene

Pathways & Interactions for MIR4452 Gene

PathCards logo

SuperPathways for MIR4452 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4452 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4452 Gene

Drugs & Compounds for MIR4452 Gene

No Compound Related Data Available

Transcripts for MIR4452 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4452 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075A9FF_9606 miRNA 23 4

RefSeq: NR_039657,

LncBase: hsa-miR-4452,

miRBase: MIMAT0018974,

TarBase: hsa-miR-4452,

URS000075B8FF_9606 precursor_RNA 71 3

RefSeq: NR_039657,

Ensembl: ENST00000583004 (view in UCSC) ,

miRBase: MI0016798,

MIR4452 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4452 Gene

No ASD Table

Relevant External Links for MIR4452 Gene

GeneLoc Exon Structure for
MIR4452

No data available for mRNA/cDNA for MIR4452 Gene

Expression for MIR4452 Gene

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4452 Gene

Orthologs for MIR4452 Gene

Evolution for MIR4452 Gene

ENSEMBL:
Gene Tree for MIR4452 (if available)
TreeFam:
Gene Tree for MIR4452 (if available)

No data available for Orthologs for MIR4452 Gene

Paralogs for MIR4452 Gene

No data available for Paralogs for MIR4452 Gene

Variants for MIR4452 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR4452 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR4452 Gene

Variant ID Type Subtype PubMed ID
esv2759264 CNV loss 17122850
nsv4411 CNV insertion 18451855
nsv594786 CNV gain 21841781
nsv594787 CNV gain 21841781

Additional Variant Information for MIR4452 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4452

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4452 Gene

Disorders for MIR4452 Gene

Additional Disease Information for MIR4452

No disorders were found for MIR4452 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4452 Gene

Publications for MIR4452 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4452 Gene

Sources for MIR4452 Gene