microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4451 Gene

Subcategory (RNA class) for MIR4451 Gene

miRNA

Number of RNA Genes sources:

2 / 17

Aliases for MIR4451 Gene

  • MicroRNA 4451 2 3 5
  • Hsa-Mir-4451 2 3
  • MIR4451 2 5
  • MIMAT0018973 50
  • MI0016797 50
  • Mir-4451 3

External Ids for MIR4451 Gene

Previous GeneCards Identifiers for MIR4451 Gene

  • GC04U901501
  • GC04P086645

Summaries for MIR4451 Gene

Entrez Gene Summary for MIR4451 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4451 Gene

MIR4451 (MicroRNA 4451) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4451 include Hypopharynx Cancer and Autosomal Recessive Congenital Ichthyosis.

Additional gene information for MIR4451 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4451 Gene

Genomics for MIR4451 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4451 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J085720 Enhancer 0.8 Ensembl ENCODE dbSUPER 600.7 -1.3 -1267 1.6 CEBPB SP1 JUND FOSL1 FOSL2 FOS NR3C1 MIR4451 KR153194-149 ARHGAP24 PTPN13
GH04J085722 Enhancer 0.3 ENCODE dbSUPER 600.7 +0.8 751 1.9 MIR4451 MN298114-157 ARHGAP24 PTPN13
GH04J085724 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 0.7 +3.4 3430 2.4 IKZF1 ETV6 JUND IKZF2 DPF2 HDAC1 SOX6 RELA EED ZNF766 MIR4451 MN298114-157 ARHGAP24 PTPN13
GH04J085734 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 +12.6 12633 6.2 ZNF629 JUND TCF12 HDAC1 SOX6 FOXJ2 EED DPF2 RUNX3 NFE2 ARHGAP24 MN298114-157 MIR4451 PTPN13
GH04J085700 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 0.4 -21.1 -21058 2.7 BACH1 RELA TCF12 IKZF2 TRIM22 ARID3A DPF2 RELB RUNX3 BCL11A ARHGAP24 MAPK10-AS1 KR153194-149 MIR4451 PTPN13
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4451 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4451 Gene

Genomic Locations for MIR4451 Gene
chr4:85,722,468-85,722,533
(GRCh38/hg38)
Size:
66 bases
Orientation:
Plus strand
chr4:86,643,621-86,643,686
(GRCh37/hg19)
Size:
66 bases
Orientation:
Plus strand

Genomic View for MIR4451 Gene

Genes around MIR4451 on UCSC Golden Path with GeneCards custom track
MIR4451 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4451 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4451 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4451 Gene

Proteins for MIR4451 Gene

Post-translational modifications for MIR4451 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4451 Gene

Domains & Families for MIR4451 Gene

Gene Families for MIR4451 Gene

HGNC:
genes like me logo Genes that share domains with MIR4451: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4451 Gene

Function for MIR4451 Gene

Phenotypes From GWAS Catalog for MIR4451 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4451 Gene

Localization for MIR4451 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4451 Gene

Pathways & Interactions for MIR4451 Gene

PathCards logo

SuperPathways for MIR4451 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4451 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4451 Gene

Drugs & Compounds for MIR4451 Gene

No Compound Related Data Available

Transcripts for MIR4451 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4451 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075B8AC_9606 precursor_RNA 66 5

HGNC: 41858,

RefSeq: NR_039656,

Ensembl: ENST00000580577 (view in UCSC) ,

miRBase: MI0016797,

ENA: LM611305.1:1..66:precursor_RNA,

URS000037E170_9606 miRNA 17 3

RefSeq: NR_039656,

miRBase: MIMAT0018973,

ENA: LM382398.1:1..17:ncRNA, LM611305.1:48..64:ncRNA,

MIR4451 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR4451 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4451 Gene

No ASD Table

Relevant External Links for MIR4451 Gene

GeneLoc Exon Structure for
MIR4451

Expression for MIR4451 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR4451

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4451 Gene

Orthologs for MIR4451 Gene

Evolution for MIR4451 Gene

ENSEMBL:
Gene Tree for MIR4451 (if available)
TreeFam:
Gene Tree for MIR4451 (if available)

No data available for Orthologs for MIR4451 Gene

Paralogs for MIR4451 Gene

No data available for Paralogs for MIR4451 Gene

Variants for MIR4451 Gene

Additional dbSNP identifiers (rs#s) for MIR4451 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4451 Gene

Variant ID Type Subtype PubMed ID
nsv461566 CNV gain 19166990
nsv470048 CNV gain 18288195
nsv594747 CNV gain 21841781
nsv829999 CNV gain 17160897

Additional Variant Information for MIR4451 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4451

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4451 Gene

Disorders for MIR4451 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR4451 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hypopharynx cancer
  • hypopharyngeal cancer
autosomal recessive congenital ichthyosis
  • arci
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR4451: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR4451 Gene

Publications for MIR4451 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4451 Gene

Sources for MIR4451 Gene