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Aliases for MIR4451 Gene

Subcategory (RNA class) for MIR4451 Gene


Quality Score for this RNA gene is


Aliases for MIR4451 Gene

  • MicroRNA 4451 2 3 5
  • Hsa-Mir-4451 3
  • Mir-4451 3

External Ids for MIR4451 Gene

Previous GeneCards Identifiers for MIR4451 Gene

  • GC04U901501
  • GC04P086645

Summaries for MIR4451 Gene

Entrez Gene Summary for MIR4451 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4451 Gene

MIR4451 (MicroRNA 4451) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4451 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4451 Gene

Genomics for MIR4451 Gene

GeneHancer (GH) Regulatory Elements for MIR4451 Gene

Promoters and enhancers for MIR4451 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I085720 Enhancer 0.7 ENCODE dbSUPER 550.8 -1.5 -1501 1.1 FOSL1 SP1 JUND FOSL2 FOS MIR4451 LOC105377319 ARHGAP24
GH04I085722 Enhancer 0.4 ENCODE dbSUPER 550.8 +0.8 751 1.9 MIR4451 GC04P085763 ARHGAP24
GH04I085724 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 0.8 +3.4 3430 2.4 HDAC1 BATF IRF4 TCF12 ZNF766 EGR1 ETV6 ATF7 BCLAF1 IKZF2 MIR4451 GC04P085763 ARHGAP24
GH04I085740 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 0.3 +20.6 20556 4.4 PKNOX1 SMAD1 ATF1 TAF9B NFIB ARNT TCF12 ZNF766 FOS ATF7 ARHGAP24 MIR4451 GC04P085763
GH04I085735 Enhancer 1.1 Ensembl ENCODE dbSUPER 0.4 +12.2 12151 0.4 HDAC1 MEIS2 JUN PYGO2 ZEB1 FOSL1 CCNT2 NFE2 RCOR1 FOS MIR4451 GC04P085763 ARHGAP24
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4451 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4451 Gene

Genomic Locations for MIR4451 Gene
66 bases
Plus strand

Genomic View for MIR4451 Gene

Genes around MIR4451 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4451 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4451 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4451 Gene

Proteins for MIR4451 Gene

Post-translational modifications for MIR4451 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4451 Gene

Domains & Families for MIR4451 Gene

Gene Families for MIR4451 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4451: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4451 Gene

Function for MIR4451 Gene

Phenotypes From GWAS Catalog for MIR4451 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4451 Gene

Localization for MIR4451 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4451 Gene

Pathways & Interactions for MIR4451 Gene

SuperPathways for MIR4451 Gene

No Data Available

Interacting Proteins for MIR4451 Gene

Gene Ontology (GO) - Biological Process for MIR4451 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR4451 Gene

Drugs & Compounds for MIR4451 Gene

No Compound Related Data Available

Transcripts for MIR4451 Gene

mRNA/cDNA for MIR4451 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4451 Gene

No ASD Table

Relevant External Links for MIR4451 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR4451 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4451 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4451 Gene

Orthologs for MIR4451 Gene

Evolution for MIR4451 Gene

Gene Tree for MIR4451 (if available)
Gene Tree for MIR4451 (if available)

No data available for Orthologs for MIR4451 Gene

Paralogs for MIR4451 Gene

No data available for Paralogs for MIR4451 Gene

Variants for MIR4451 Gene

Sequence variations from dbSNP and Humsavar for MIR4451 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000728570 -- 85,721,399(+) AAACAAACAAA/AAACAAA upstream_transcript_variant
rs1001174448 -- 85,722,538(+) C/T downstream_transcript_variant
rs1002178268 -- 85,721,420(+) A/G upstream_transcript_variant
rs1002209372 -- 85,721,687(+) T/C upstream_transcript_variant
rs1003429057 -- 85,723,034(+) A/G

Structural Variations from Database of Genomic Variants (DGV) for MIR4451 Gene

Variant ID Type Subtype PubMed ID
nsv829999 CNV gain 17160897
nsv594747 CNV gain 21841781
nsv470048 CNV gain 18288195
nsv461566 CNV gain 19166990

Additional Variant Information for MIR4451 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4451 Gene

Disorders for MIR4451 Gene

Additional Disease Information for MIR4451

No disorders were found for MIR4451 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4451 Gene

Publications for MIR4451 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  2. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 58
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4451 Gene

Sources for MIR4451 Gene

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