microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4448 Gene

Subcategory (RNA class) for MIR4448 Gene

miRNA

Number of RNA Genes sources:

4 / 14

Aliases for MIR4448 Gene

  • MicroRNA 4448 2 3 5
  • Hsa-MiR-4448 166 177
  • Hsa-Mir-4448 3
  • MIMAT0018967 51
  • MI0016791 51
  • MIR4448 2

External Ids for MIR4448 Gene

Previous GeneCards Identifiers for MIR4448 Gene

  • GC03U901791
  • GC03P183609

Summaries for MIR4448 Gene

Entrez Gene Summary for MIR4448 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4448 Gene

MIR4448 (MicroRNA 4448) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Parkinsons Disease Pathway.

Additional gene information for MIR4448 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4448 Gene

Genomics for MIR4448 Gene

Genomic Locations for MIR4448 Gene

Genomic Locations for MIR4448 Gene
chr3:183,886,800-183,886,885
(GRCh38/hg38)
Size:
86 bases
Orientation:
Plus strand
chr3:183,604,588-183,604,673
(GRCh37/hg19)
Size:
86 bases
Orientation:
Plus strand

Genomic View for MIR4448 Gene

Genes around MIR4448 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4448 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4448 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4448 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR4448 Gene

Proteins for MIR4448 Gene

Post-translational modifications for MIR4448 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4448 Gene

Domains & Families for MIR4448 Gene

Gene Families for MIR4448 Gene

HGNC:
genes like me logo Genes that share domains with MIR4448: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4448 Gene

Function for MIR4448 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4448 Gene

Localization for MIR4448 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR4448 gene
Compartment Confidence
plasma membrane 1
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4448 Gene

Pathways & Interactions for MIR4448 Gene

PathCards logo

SuperPathways for MIR4448 Gene

SuperPathway Contained pathways
1 Parkinsons Disease Pathway
genes like me logo Genes that share pathways with MIR4448: view

Pathways by source for MIR4448 Gene

1 BioSystems pathway for MIR4448 Gene
;

Gene Ontology (GO) - Biological Process for MIR4448 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR4448 Gene

Drugs & Compounds for MIR4448 Gene

No Compound Related Data Available

Transcripts for MIR4448 Gene

mRNA/cDNA for MIR4448 Gene

2 RNACentral transcripts :
1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 miRBase transcripts :
3 ENA transcripts :
1 LncBase transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4448 Gene

No ASD Table

Relevant External Links for MIR4448 Gene

GeneLoc Exon Structure for
MIR4448

Expression for MIR4448 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4448 Gene

genes like me logo Genes that share expression patterns with MIR4448: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4448 Gene

Orthologs for MIR4448 Gene

Evolution for MIR4448 Gene

ENSEMBL:
Gene Tree for MIR4448 (if available)
TreeFam:
Gene Tree for MIR4448 (if available)

No data available for Orthologs for MIR4448 Gene

Paralogs for MIR4448 Gene

No data available for Paralogs for MIR4448 Gene

Variants for MIR4448 Gene

Additional dbSNP identifiers (rs#s) for MIR4448 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4448 Gene

Variant ID Type Subtype PubMed ID
esv3598933 CNV gain 21293372
nsv592656 CNV gain 21841781
nsv979908 CNV duplication 23825009

Additional Variant Information for MIR4448 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4448

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4448 Gene

Disorders for MIR4448 Gene

Additional Disease Information for MIR4448

No disorders were found for MIR4448 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4448 Gene

Publications for MIR4448 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 54
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54

Products for MIR4448 Gene

Sources for MIR4448 Gene