microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4439 Gene

Data sources for MIR4439 Gene:

Subcategory (RNA class) for MIR4439 Gene

miRNA

Aliases for MIR4439 Gene

External Ids for MIR4439 Gene

Previous GeneCards Identifiers for MIR4439 Gene

  • GC02U902452
  • GC02M225877

Summaries for MIR4439 Gene

Entrez Gene Summary for MIR4439 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4439 Gene

MIR4439 (MicroRNA 4439) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4439 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4439 Gene

Genomics for MIR4439 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4439 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J225009 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 250.7 -0.4 -402 2.8 YY1 FOSL1 JUND MAFK GLIS1 POLR2A CTCF NFE2L2 FOS EP300 MIR4439 DOCK10 NYAP2 lnc-NYAP2-10 CCDC195
GH02J225010 Enhancer 0.7 ENCODE dbSUPER 250.7 +1.4 1401 0.1 CTCF SMARCA5 RAD21 ZNF143 DPF2 SMC3 ZNF654 MIR4439 DOCK10 lnc-NYAP2-10 CCDC195
GH02J225037 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.3 -30.0 -30039 6 ZBTB10 BCL11A POLR2A SIN3A REST EBF1 SMARCA5 MAX CBFB TAF1 DOCK10 NYAP2 CUL3 MIR4439 lnc-NYAP2-10 CCDC195
GH02J224992 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +11.1 11139 12 CTCF FOXA2 TRIM22 MAFF EBF1 SMC3 RAD21 SMARCA5 ZNF2 MAFK NYAP2 DOCK10 MIR4439 lnc-NYAP2-10 CCDC195
GH02J224981 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.3 +27.7 27697 4.9 EBF1 NR2F1 ATF2 RCOR1 GATA2 IKZF1 POLR2A CHD2 TCF12 RUNX3 NYAP2 lnc-NYAP2-10 MIR4439 DOCK10 CCDC195
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4439 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4439 Gene

Latest Assembly
chr2:225,010,461-225,010,540
(GRCh38/hg38)
Size:
80 bases
Orientation:
Minus strand

Previous Assembly
chr2:225,875,178-225,875,257
(GRCh37/hg19 by Entrez Gene)
Size:
80 bases
Orientation:
Minus strand

chr2:225,875,178-225,875,257
(GRCh37/hg19 by Ensembl)
Size:
80 bases
Orientation:
Minus strand

Genomic View for MIR4439 Gene

Genes around MIR4439 on UCSC Golden Path with GeneCards custom track
MIR4439 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR4439 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4439 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4439 Gene

Proteins for MIR4439 Gene

Post-translational modifications for MIR4439 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4439 Gene

Domains & Families for MIR4439 Gene

Gene Families for MIR4439 Gene

HGNC:
genes like me logo Genes that share domains with MIR4439: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4439 Gene

Function for MIR4439 Gene

Phenotypes From GWAS Catalog for MIR4439 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4439 Gene

Localization for MIR4439 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4439 Gene

Pathways & Interactions for MIR4439 Gene

PathCards logo

SuperPathways for MIR4439 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4439 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4439 Gene

Drugs & Compounds for MIR4439 Gene

No Compound Related Data Available

Transcripts for MIR4439 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4439 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075A963_9606 pre_miRNA 80 3

RefSeq: NR_039641,

Ensembl: ENST00000583746 (view in UCSC) ,

miRBase: MI0016782,

URS000075E7F6_9606 miRNA 22 2

RefSeq: NR_039641,

miRBase: MIMAT0018957,

MIR4439 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4439 Gene

No ASD Table

Relevant External Links for MIR4439 Gene

GeneLoc Exon Structure for
MIR4439

No data available for mRNA/cDNA for MIR4439 Gene

Expression for MIR4439 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4439 Gene

genes like me logo Genes that share expression patterns with MIR4439: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4439 Gene

Orthologs for MIR4439 Gene

Evolution for MIR4439 Gene

ENSEMBL:
Gene Tree for MIR4439 (if available)
TreeFam:
Gene Tree for MIR4439 (if available)

No data available for Orthologs for MIR4439 Gene

Paralogs for MIR4439 Gene

No data available for Paralogs for MIR4439 Gene

Variants for MIR4439 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR4439 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for MIR4439 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4439

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR4439 Gene

Disorders for MIR4439 Gene

Additional Disease Information for MIR4439

No disorders were found for MIR4439 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4439 Gene

Publications for MIR4439 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4439 Gene

Sources for MIR4439 Gene