microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4434 Gene

Subcategory (RNA class) for MIR4434 Gene

miRNA

Number of RNA Genes sources:

1 / 14

Aliases for MIR4434 Gene

  • MicroRNA 4434 2 3 5
  • Hsa-Mir-4434 3
  • MIMAT0018950 51
  • MI0016774 51
  • MIR4434 2

External Ids for MIR4434 Gene

Previous GeneCards Identifiers for MIR4434 Gene

  • GC02U902437
  • GC02P064754

Summaries for MIR4434 Gene

Entrez Gene Summary for MIR4434 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4434 Gene

MIR4434 (MicroRNA 4434) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4434 include Danubian Endemic Familial Nephropathy.

Additional gene information for MIR4434 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4434 Gene

Genomics for MIR4434 Gene

GeneHancer (GH) Regulatory Elements for MIR4434 Gene

Promoters and enhancers for MIR4434 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J064522 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 -0.1 -112 5.6 EP300 FOXK2 ZBTB40 ZNF217 CTCF SIN3A NRF1 POLR2G GTF2E2 PHF8 AFTPH ENSG00000260101 LOC101927402 MIR4434 VPS54 SERTAD2
GH02J064534 Promoter 0.8 Ensembl 0.4 +9.2 9188 0.2 BATF ELF1 IRF4 IKZF1 NR2F1 ATF2 JUNB NFATC1 MTA3 SPI1 MIR4434 AFTPH LOC105374773
GH02J064542 Enhancer 0.6 ENCODE 0.4 +17.3 17319 0.2 TCF12 NCOR1 ZSCAN9 ZNF316 FOXA2 MAFF FOSL2 MAFK FOXA1 ZGPAT AFTPH LOC105374773 MIR4434
GH02J064546 Enhancer 0.4 Ensembl 0.4 +20.2 20188 0.2 ZNF384 ZNF362 ZNF652 SOX13 AFTPH LOC105374773 MIR4434
GH02J064547 Enhancer 0.3 Ensembl 0.4 +22.6 22588 3 FOXA2 SREBF1 AFTPH LOC105374773 MIR4434
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4434 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4434 Gene

Genomic Locations for MIR4434 Gene
chr2:64,525,513-64,525,565
(GRCh38/hg38)
Size:
53 bases
Orientation:
Plus strand
chr2:64,752,647-64,752,699
(GRCh37/hg19)
Size:
53 bases
Orientation:
Plus strand

Genomic View for MIR4434 Gene

Genes around MIR4434 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4434 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4434 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4434 Gene

Proteins for MIR4434 Gene

Post-translational modifications for MIR4434 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4434 Gene

Domains & Families for MIR4434 Gene

Gene Families for MIR4434 Gene

HGNC:
genes like me logo Genes that share domains with MIR4434: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4434 Gene

Function for MIR4434 Gene

Phenotypes From GWAS Catalog for MIR4434 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4434 Gene

Localization for MIR4434 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4434 Gene

Pathways & Interactions for MIR4434 Gene

PathCards logo

SuperPathways for MIR4434 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR4434 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4434 Gene

Drugs & Compounds for MIR4434 Gene

No Compound Related Data Available

Transcripts for MIR4434 Gene

mRNA/cDNA for MIR4434 Gene

2 RNACentral transcripts :
1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 miRBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4434 Gene

No ASD Table

Relevant External Links for MIR4434 Gene

GeneLoc Exon Structure for
MIR4434

Expression for MIR4434 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4434 Gene

Orthologs for MIR4434 Gene

Evolution for MIR4434 Gene

ENSEMBL:
Gene Tree for MIR4434 (if available)
TreeFam:
Gene Tree for MIR4434 (if available)

No data available for Orthologs for MIR4434 Gene

Paralogs for MIR4434 Gene

No data available for Paralogs for MIR4434 Gene

Variants for MIR4434 Gene

Additional dbSNP identifiers (rs#s) for MIR4434 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4434 Gene

Variant ID Type Subtype PubMed ID
nsv1006553 CNV gain 25217958
nsv2754 CNV insertion 18451855
nsv582127 CNV gain 21841781
nsv7313 OTHER inversion 18451855
nsv834245 CNV gain 17160897

Additional Variant Information for MIR4434 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4434

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4434 Gene

Disorders for MIR4434 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR4434 Gene - From: DISEASES

Disorder Aliases PubMed IDs
danubian endemic familial nephropathy
  • defn
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR4434

genes like me logo Genes that share disorders with MIR4434: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR4434 Gene

Publications for MIR4434 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 54
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54

Products for MIR4434 Gene

Sources for MIR4434 Gene