microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4433B Gene

Subcategory (RNA class) for MIR4433B Gene

miRNA

Number of RNA Genes sources:

1 / 14

Aliases for MIR4433B Gene

  • MicroRNA 4433b 2 3 5
  • MicroRNA Mir-4433b 3
  • Hsa-Mir-4433b 3
  • MIMAT0030414 51
  • MIMAT0030413 51
  • MI0025511 51
  • MIR4433B 2

External Ids for MIR4433B Gene

Previous GeneCards Identifiers for MIR4433B Gene

  • GC02U903013

Summaries for MIR4433B Gene

Entrez Gene Summary for MIR4433B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4433B Gene

MIR4433B (MicroRNA 4433b) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4433B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4433B Gene

Genomics for MIR4433B Gene

GeneHancer (GH) Regulatory Elements for MIR4433B Gene

Promoters and enhancers for MIR4433B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J064338 Enhancer 0.5 Ensembl 500.7 +1.6 1647 0.8 ZIC2 CBFB YY1 BATF JUNB NFIC RUNX3 MIR4433A MIR4433B lnc-LGALSL-6 LOC105374769 ENSG00000237217 LGALSL LGALSL-DT AFTPH ENSG00000228305 ENSG00000238201
GH02J064342 Enhancer 0.3 Ensembl 500.7 -1.9 -1930 0.8 PRDM10 ENSG00000238201 MIR4433B LOC105374768 ENSG00000237217 LGALSL LGALSL-DT LOC105374769 RPL23AP37 lnc-LGALSL-6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4433B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4433B Gene

Genomic Locations for MIR4433B Gene
chr2:64,340,747-64,340,848
(GRCh38/hg38)
Size:
102 bases
Orientation:
Minus strand

Genomic View for MIR4433B Gene

Genes around MIR4433B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4433B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4433B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4433B Gene

Proteins for MIR4433B Gene

Post-translational modifications for MIR4433B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4433B Gene

Domains & Families for MIR4433B Gene

Gene Families for MIR4433B Gene

HGNC:
genes like me logo Genes that share domains with MIR4433B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4433B Gene

Function for MIR4433B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4433B Gene

Localization for MIR4433B Gene

Gene Ontology (GO) - Cellular Components for MIR4433B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR4433B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR4433B Gene

Pathways & Interactions for MIR4433B Gene

PathCards logo

SuperPathways for MIR4433B Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR4433B Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4433B Gene

Drugs & Compounds for MIR4433B Gene

No Compound Related Data Available

Transcripts for MIR4433B Gene

mRNA/cDNA for MIR4433B Gene

3 RNACentral transcripts :
1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4433B Gene

No ASD Table

Relevant External Links for MIR4433B Gene

GeneLoc Exon Structure for
MIR4433B

Expression for MIR4433B Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4433B Gene

Orthologs for MIR4433B Gene

Evolution for MIR4433B Gene

ENSEMBL:
Gene Tree for MIR4433B (if available)
TreeFam:
Gene Tree for MIR4433B (if available)

No data available for Orthologs for MIR4433B Gene

Paralogs for MIR4433B Gene

No data available for Paralogs for MIR4433B Gene

Variants for MIR4433B Gene

Additional dbSNP identifiers (rs#s) for MIR4433B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4433B Gene

Variant ID Type Subtype PubMed ID
nsv1006553 CNV gain 25217958
nsv1013132 CNV loss 25217958
nsv582126 CNV gain 21841781
nsv582127 CNV gain 21841781
nsv7313 OTHER inversion 18451855
nsv834244 CNV gain 17160897

Additional Variant Information for MIR4433B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4433B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4433B Gene

Disorders for MIR4433B Gene

Additional Disease Information for MIR4433B

No disorders were found for MIR4433B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4433B Gene

Publications for MIR4433B Gene

  1. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 54
  2. The repertoire and features of human platelet microRNAs. (PMID: 23226537) Plé H … Provost P (PloS one 2012) 3 54
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54

Products for MIR4433B Gene

Sources for MIR4433B Gene