microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4433A Gene

Data sources for MIR4433A Gene:

Subcategory (RNA class) for MIR4433A Gene

miRNA

Aliases for MIR4433A Gene

External Ids for MIR4433A Gene

Previous HGNC Symbols for MIR4433A Gene

  • MIR4433

Summaries for MIR4433A Gene

Entrez Gene Summary for MIR4433A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4433A Gene

MIR4433A (MicroRNA 4433a) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4433A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4433A Gene

Genomics for MIR4433A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4433A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J064338 Enhancer 0.5 Ensembl 250.7 -1.7 -1658 1 ZIC2 YY1 CBFB BATF JUNB RUNX3 MIR4433A MIR4433B lnc-LGALSL-6 ENSG00000238012 ENSG00000237217 LGALSL LGALSL-DT AFTPH PRELID1P6 ENSG00000238201
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4433A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4433A Gene

Latest Assembly
chr2:64,340,759-64,340,839
(GRCh38/hg38)
Size:
81 bases
Orientation:
Plus strand

Previous Assembly
chr2:64,567,893-64,567,973
(GRCh37/hg19 by Entrez Gene)
Size:
81 bases
Orientation:
Plus strand

Genomic View for MIR4433A Gene

Genes around MIR4433A on UCSC Golden Path with GeneCards custom track
MIR4433A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR4433A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4433A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4433A Gene

Proteins for MIR4433A Gene

Post-translational modifications for MIR4433A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4433A Gene

Domains & Families for MIR4433A Gene

Gene Families for MIR4433A Gene

HGNC:
genes like me logo Genes that share domains with MIR4433A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4433A Gene

Function for MIR4433A Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4433A Gene

Localization for MIR4433A Gene

Gene Ontology (GO) - Cellular Components for MIR4433A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 31926946
genes like me logo Genes that share ontologies with MIR4433A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR4433A Gene

Pathways & Interactions for MIR4433A Gene

PathCards logo

SuperPathways for MIR4433A Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4433A Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4433A Gene

Drugs & Compounds for MIR4433A Gene

No Compound Related Data Available

Transcripts for MIR4433A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4433A Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075C7DE_9606 pre_miRNA 81 3

RefSeq: NR_039632,

Ensembl: ENST00000637652 (view in UCSC) ,

miRBase: MI0016773,

URS00005A3BC9_9606 miRNA 21 2

RefSeq: NR_039632,

miRBase: MIMAT0018949,

URS000075A620_9606 miRNA 21 2

RefSeq: NR_039632,

miRBase: MIMAT0020956,

MIR4433A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4433A Gene

No ASD Table

Relevant External Links for MIR4433A Gene

GeneLoc Exon Structure for
MIR4433A

No data available for mRNA/cDNA for MIR4433A Gene

Expression for MIR4433A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4433A Gene

genes like me logo Genes that share expression patterns with MIR4433A: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4433A Gene

Orthologs for MIR4433A Gene

Evolution for MIR4433A Gene

ENSEMBL:
Gene Tree for MIR4433A (if available)
TreeFam:
Gene Tree for MIR4433A (if available)

No data available for Orthologs for MIR4433A Gene

Paralogs for MIR4433A Gene

No data available for Paralogs for MIR4433A Gene

Variants for MIR4433A Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR4433A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR4433A Gene

Variant ID Type Subtype PubMed ID
nsv1006553 CNV gain 25217958
nsv1013132 CNV loss 25217958
nsv582126 CNV gain 21841781
nsv582127 CNV gain 21841781
nsv7313 OTHER inversion 18451855
nsv834244 CNV gain 17160897

Additional Variant Information for MIR4433A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4433A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4433A Gene

Disorders for MIR4433A Gene

Additional Disease Information for MIR4433A

No disorders were found for MIR4433A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4433A Gene

Publications for MIR4433A Gene

  1. Exosomal miR-146a-5p from Treponema pallidum-stimulated macrophages reduces endothelial cells permeability and monocyte transendothelial migration by targeting JAM-C. (PMID: 31926946) Hu W … Zhang R (Experimental cell research 2020) 3
  2. Enhancing miRNA annotation confidence in miRBase by continuous cross dataset analysis. (PMID: 21558790) Hansen TB … Bramsen JB (RNA biology 2011) 3
  3. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4433A Gene

Sources for MIR4433A Gene