microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4430 Gene

Subcategory (RNA class) for MIR4430 Gene

miRNA

Number of RNA Genes sources:

2 / 14

Aliases for MIR4430 Gene

  • MicroRNA 4430 2 3 5
  • Hsa-Mir-4430 3
  • MIMAT0018945 51
  • MI0016769 51
  • MIR4430 2

External Ids for MIR4430 Gene

Previous GeneCards Identifiers for MIR4430 Gene

  • GC02U902436
  • GC02P033645

Summaries for MIR4430 Gene

Entrez Gene Summary for MIR4430 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4430 Gene

MIR4430 (MicroRNA 4430) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4430 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4430 Gene

Genomics for MIR4430 Gene

GeneHancer (GH) Regulatory Elements for MIR4430 Gene

Promoters and enhancers for MIR4430 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J033420 Enhancer 0.7 FANTOM5 Ensembl 500.7 +1.8 1784 2.6 USF1 ZFHX2 CTCF GATA2 EGR2 MIR4430 RASGRP3
GH02J033415 Enhancer 0.3 Ensembl 500.7 -1.5 -1515 3.2 ZFP91 CEBPB MIR4430 RASGRP3 piR-61101-378
GH02J033411 Enhancer 0.9 Ensembl ENCODE 0.4 -6.2 -6174 2.1 CTCF TCF12 JUND FOS ZIC2 RFX1 REST RAD21 ATF2 SMC3 RASGRP3 ENSG00000206951 LTBP1 MIR4430 piR-61101-378
GH02J033425 Enhancer 0.8 Ensembl ENCODE 0.4 +7.9 7885 2.4 JUND REST NFIC USF1 FOS MYC PKNOX1 JUN NFIA L3MBTL2 RASGRP3 MIR4430
GH02J033396 Enhancer 0.8 Ensembl ENCODE 0.4 -21.6 -21629 0.6 MYC TEAD4 TCF7 TEAD1 HDAC2 CEBPB NANOG TCF12 KDM1A JUND piR-61101-378 MIR4430 LTBP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4430 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4430 Gene

Genomic Locations for MIR4430 Gene
chr2:33,418,516-33,418,564
(GRCh38/hg38)
Size:
49 bases
Orientation:
Plus strand
chr2:33,643,583-33,643,631
(GRCh37/hg19)
Size:
49 bases
Orientation:
Plus strand

Genomic View for MIR4430 Gene

Genes around MIR4430 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4430 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4430 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4430 Gene

Proteins for MIR4430 Gene

Post-translational modifications for MIR4430 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4430 Gene

Domains & Families for MIR4430 Gene

Gene Families for MIR4430 Gene

HGNC:
genes like me logo Genes that share domains with MIR4430: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4430 Gene

Function for MIR4430 Gene

Phenotypes From GWAS Catalog for MIR4430 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4430 Gene

Localization for MIR4430 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4430 Gene

Pathways & Interactions for MIR4430 Gene

PathCards logo

SuperPathways for MIR4430 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR4430 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4430 Gene

Drugs & Compounds for MIR4430 Gene

No Compound Related Data Available

Transcripts for MIR4430 Gene

mRNA/cDNA for MIR4430 Gene

2 RNACentral transcripts :
1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 miRBase transcripts :
3 ENA transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4430 Gene

No ASD Table

Relevant External Links for MIR4430 Gene

GeneLoc Exon Structure for
MIR4430

Expression for MIR4430 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4430 Gene

Orthologs for MIR4430 Gene

Evolution for MIR4430 Gene

ENSEMBL:
Gene Tree for MIR4430 (if available)
TreeFam:
Gene Tree for MIR4430 (if available)

No data available for Orthologs for MIR4430 Gene

Paralogs for MIR4430 Gene

No data available for Paralogs for MIR4430 Gene

Variants for MIR4430 Gene

Additional dbSNP identifiers (rs#s) for MIR4430 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4430 Gene

Variant ID Type Subtype PubMed ID
esv3590286 CNV loss 21293372
esv3891725 CNV gain 25118596

Additional Variant Information for MIR4430 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4430

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4430 Gene

Disorders for MIR4430 Gene

Additional Disease Information for MIR4430

No disorders were found for MIR4430 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4430 Gene

Publications for MIR4430 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 54
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54

Products for MIR4430 Gene

Sources for MIR4430 Gene