microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4428 Gene

Subcategory (RNA class) for MIR4428 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR4428 Gene

  • MicroRNA 4428 2 3 5
  • Hsa-Mir-4428 3
  • MIMAT0018943 53
  • MI0016767 53
  • MIR4428 2

External Ids for MIR4428 Gene

Previous GeneCards Identifiers for MIR4428 Gene

  • GC01U903286
  • GC01P237636

Summaries for MIR4428 Gene

Entrez Gene Summary for MIR4428 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4428 Gene

MIR4428 (MicroRNA 4428) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4428 include Catecholaminergic Polymorphic Ventricular Tachycardia.

Additional gene information for MIR4428 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4428 Gene

Genomics for MIR4428 Gene

GeneHancer (GH) Regulatory Elements for MIR4428 Gene

Promoters and enhancers for MIR4428 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J237471 Enhancer 0.6 ENCODE 750.6 0.0 -43 0.2 POLR2A MYC MAX ZNF512 CEBPB MXI1 ZNF10 ZBTB17 RFX5 USF2 MIR4428 piR-60051-006 RYR2
GH01J237506 Enhancer 0.6 Ensembl 0.3 +36.0 35982 0.6 ZNF24 ETV6 PRDM1 IKZF2 RUNX3 ZNF592 IRF4 EZH2 ATF2 ZNF217 piR-38051-026 MIR4428 RYR2
GH01J237481 Enhancer 0.3 FANTOM5 0.4 +10.8 10780 0.2 ZNF362 RYR2 MIR4428 piR-38051-026
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4428 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4428 Gene

Genomic Locations for MIR4428 Gene
chr1:237,471,119-237,471,191
(GRCh38/hg38)
Size:
73 bases
Orientation:
Plus strand
chr1:237,634,419-237,634,491
(GRCh37/hg19)
Size:
73 bases
Orientation:
Plus strand

Genomic View for MIR4428 Gene

Genes around MIR4428 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4428 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4428 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4428 Gene

Proteins for MIR4428 Gene

Post-translational modifications for MIR4428 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4428 Gene

Domains & Families for MIR4428 Gene

Gene Families for MIR4428 Gene

HGNC:
genes like me logo Genes that share domains with MIR4428: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4428 Gene

Function for MIR4428 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4428 Gene

Localization for MIR4428 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4428 Gene

Pathways & Interactions for MIR4428 Gene

PathCards logo

SuperPathways for MIR4428 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4428 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4428 Gene

Drugs & Compounds for MIR4428 Gene

No Compound Related Data Available

Transcripts for MIR4428 Gene

mRNA/cDNA for MIR4428 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNACentral transcripts :
(2) miRBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4428 Gene

No ASD Table

Relevant External Links for MIR4428 Gene

GeneLoc Exon Structure for
MIR4428
ECgene alternative splicing isoforms for
MIR4428

Expression for MIR4428 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4428 Gene:

MIR4428
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4428 Gene

Orthologs for MIR4428 Gene

Evolution for MIR4428 Gene

ENSEMBL:
Gene Tree for MIR4428 (if available)
TreeFam:
Gene Tree for MIR4428 (if available)

No data available for Orthologs for MIR4428 Gene

Paralogs for MIR4428 Gene

No data available for Paralogs for MIR4428 Gene

Variants for MIR4428 Gene

Sequence variations from dbSNP and Humsavar for MIR4428 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1553462870 likely-benign, Catecholaminergic polymorphic ventricular tachycardia 237,469,126(+) T/C upstream_transcript_variant
rs371262363 likely-benign, Catecholaminergic polymorphic ventricular tachycardia, not specified, Cardiovascular phenotype 237,469,144(+) C/A/T upstream_transcript_variant
rs773609522 uncertain-significance, not provided 237,469,154(+) A/G upstream_transcript_variant
rs794728722 uncertain-significance, not provided 237,469,120(+) C/A upstream_transcript_variant
rs1001999014 -- 237,471,129(+) C/T non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4428 Gene

Variant ID Type Subtype PubMed ID
nsv1006191 CNV gain 25217958
nsv549415 CNV gain 21841781

Additional Variant Information for MIR4428 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4428

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4428 Gene

Disorders for MIR4428 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR4428 Gene - From: GeneCards

Disorder Aliases PubMed IDs
catecholaminergic polymorphic ventricular tachycardia
  • ventricular tachycardia, catecholaminergic polymorphic, 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR4428

genes like me logo Genes that share disorders with MIR4428: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR4428 Gene

Publications for MIR4428 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 56
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 56

Products for MIR4428 Gene

Sources for MIR4428 Gene