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Aliases for MIR4427 Gene

Subcategory (RNA class) for MIR4427 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4427 Gene

  • MicroRNA 4427 2 3 5
  • Hsa-Mir-4427 3

External Ids for MIR4427 Gene

Previous GeneCards Identifiers for MIR4427 Gene

  • GC01U903255
  • GC01P233761

Summaries for MIR4427 Gene

Entrez Gene Summary for MIR4427 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4427 Gene

MIR4427 (MicroRNA 4427) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4427 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4427 Gene

Genomics for MIR4427 Gene

GeneHancer (GH) Regulatory Elements for MIR4427 Gene

Promoters and enhancers for MIR4427 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I233625 Enhancer 0.7 dbSUPER 550.8 +1.9 1887 1.6 HDAC1 TEAD4 TAL1 CHAMP1 TCF12 CTBP1 GATA2 NCOR1 CBFA2T2 ZNF600 MIR4427 KCNK1 GC01P233696
GH01I233613 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.4 -9.3 -9349 3.2 HDGF PKNOX1 SMAD1 SIN3A FEZF1 ZNF2 ZBTB7B YY1 POLR2B ZNF213 KCNK1 IRF2BP2 PCNX2 RPS7P3 MIR4427
GH01I233635 Enhancer 1.1 ENCODE 0.4 +12.0 11952 1.6 CLOCK FEZF1 ZNF213 E2F8 ZNF416 ZNF548 SP3 MEF2D ZNF610 GLIS1 RPS7P3 IRF2BP2 KCNK1 LOC101927765 NTPCR MIR4427 GC01P233696
GH01I233667 Enhancer 1.2 Ensembl ENCODE 0.3 +44.7 44712 1.9 HDGF PKNOX1 ATF1 ARNT NCOA2 TCF12 ZNF766 GATA2 E2F8 ATF7 KCNK1 TARBP1 GC01P233696 MIR4427
GH01I233665 Enhancer 1.2 ENCODE dbSUPER 0.3 +42.0 41996 0.7 PKNOX1 SMAD1 ARNT ZNF766 CBX5 REST ZNF592 MEF2D SMARCA4 NBN RPS7P3 IRF2BP2 KCNK1 GC01P233696 MIR4427
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4427 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4427 Gene

Genomic Locations for MIR4427 Gene
chr1:233,624,152-233,624,219
(GRCh38/hg38)
Size:
68 bases
Orientation:
Plus strand
chr1:233,759,898-233,759,965
(GRCh37/hg19)

Genomic View for MIR4427 Gene

Genes around MIR4427 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4427 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4427 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4427 Gene

Proteins for MIR4427 Gene

Post-translational modifications for MIR4427 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4427 Gene

Domains & Families for MIR4427 Gene

Gene Families for MIR4427 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4427: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4427 Gene

Function for MIR4427 Gene

Phenotypes From GWAS Catalog for MIR4427 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4427 Gene

Localization for MIR4427 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4427 Gene

Pathways & Interactions for MIR4427 Gene

SuperPathways for MIR4427 Gene

No Data Available

Interacting Proteins for MIR4427 Gene

Gene Ontology (GO) - Biological Process for MIR4427 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4427 Gene

Drugs & Compounds for MIR4427 Gene

No Compound Related Data Available

Transcripts for MIR4427 Gene

mRNA/cDNA for MIR4427 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4427 Gene

No ASD Table

Relevant External Links for MIR4427 Gene

GeneLoc Exon Structure for
MIR4427
ECgene alternative splicing isoforms for
MIR4427

Expression for MIR4427 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4427 Gene:

MIR4427
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4427 Gene

Orthologs for MIR4427 Gene

Evolution for MIR4427 Gene

ENSEMBL:
Gene Tree for MIR4427 (if available)
TreeFam:
Gene Tree for MIR4427 (if available)

No data available for Orthologs for MIR4427 Gene

Paralogs for MIR4427 Gene

No data available for Paralogs for MIR4427 Gene

Variants for MIR4427 Gene

Sequence variations from dbSNP and Humsavar for MIR4427 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1004045585 -- 233,623,453(+) A/G upstream_transcript_variant
rs1004758065 -- 233,623,880(+) C/T upstream_transcript_variant
rs1006475016 -- 233,624,689(+) C/G downstream_transcript_variant
rs1009160249 -- 233,622,714(+) T/G upstream_transcript_variant
rs1009518557 -- 233,622,399(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4427 Gene

Variant ID Type Subtype PubMed ID
nsv528071 CNV loss 19592680

Additional Variant Information for MIR4427 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4427

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4427 Gene

Disorders for MIR4427 Gene

Additional Disease Information for MIR4427

No disorders were found for MIR4427 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4427 Gene

Publications for MIR4427 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 58
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4427 Gene

Sources for MIR4427 Gene

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