microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4425 Gene

Subcategory (RNA class) for MIR4425 Gene

miRNA

Number of RNA Genes sources:

4 / 17

Aliases for MIR4425 Gene

  • MicroRNA 4425 2 3 5
  • Hsa-Mir-4425 2 3
  • Hsa-MiR-4425 163 173
  • MIR4425 2 5
  • MIMAT0018940 50
  • MI0016764 50

External Ids for MIR4425 Gene

Previous GeneCards Identifiers for MIR4425 Gene

  • GC01U903275
  • GC01P025351

Summaries for MIR4425 Gene

Entrez Gene Summary for MIR4425 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4425 Gene

MIR4425 (MicroRNA 4425) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4425 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4425 Gene

Genomics for MIR4425 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4425 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J025020 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 -0.8 -810 4.9 SP1 HNRNPL KDM1A BACH1 JUND LARP7 ZNF143 RELA ZIC2 PATZ1 MIR4425 RUNX3 ENSG00000229162 RSRP1 SYF2 SRRM1 lnc-RUNX3-3
GH01J025018 Enhancer 1.3 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 0.7 -4.3 -4338 1.3 SP1 KDM1A POLR2A ZNF143 RELA ZSCAN4 YY1 EED MNT ZSCAN29 RUNX3 MIR4425 lnc-RUNX3-3 SYF2
GH01J025027 Enhancer 1 FANTOM5 dbSUPER 0.7 +3.7 3711 0.3 ZNF143 RELA IKZF2 EED DPF2 RELB RUNX3 GATAD2B BCLAF1 ZNF592 RSRP1 RUNX3 SYF2 LINC02793 MIR4425
GH01J025028 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 0.4 +5.6 5632 0.9 BACH1 LARP7 STAT3 SMAD5 IKZF2 TRIM22 PKNOX1 SCRT2 EED POLR2A LINC02793 RUNX3 ENSG00000229162 MAN1C1 RSRP1 SYF2 MIR4425
GH01J025026 Enhancer 0.7 FANTOM5 dbSUPER 0.7 +3.3 3307 0.2 ZNF592 NBN IKZF1 ZNF207 MAZ CTCF MYOM3 RSRP1 RUNX3 SYF2 LINC02793 MIR4425
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4425 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4425 Gene

Genomic Locations for MIR4425 Gene
chr1:25,023,503-25,023,586
(GRCh38/hg38)
Size:
84 bases
Orientation:
Plus strand
chr1:25,349,994-25,350,077
(GRCh37/hg19)
Size:
84 bases
Orientation:
Plus strand

Genomic View for MIR4425 Gene

Genes around MIR4425 on UCSC Golden Path with GeneCards custom track
MIR4425 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4425 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4425 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4425 Gene

Proteins for MIR4425 Gene

Post-translational modifications for MIR4425 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4425 Gene

Domains & Families for MIR4425 Gene

Gene Families for MIR4425 Gene

HGNC:
genes like me logo Genes that share domains with MIR4425: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4425 Gene

Function for MIR4425 Gene

Phenotypes From GWAS Catalog for MIR4425 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4425 Gene

Localization for MIR4425 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4425 Gene

Pathways & Interactions for MIR4425 Gene

PathCards logo

SuperPathways for MIR4425 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4425 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4425 Gene

Drugs & Compounds for MIR4425 Gene

No Compound Related Data Available

Transcripts for MIR4425 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4425 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075A0D6_9606 precursor_RNA 84 5

HGNC: 41891,

RefSeq: NR_039623,

Ensembl: ENST00000580572 (view in UCSC) ,

miRBase: MI0016764,

ENA: LM611287.1:1..84:precursor_RNA,

URS000035AC91_9606 miRNA 22 5

RefSeq: NR_039623,

LncBase: hsa-miR-4425,

miRBase: MIMAT0018940,

TarBase: hsa-miR-4425,

ENA: LM382383.1:1..22:ncRNA, LM611287.1:50..71:ncRNA,

MIR4425 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4425 Gene

No ASD Table

Relevant External Links for MIR4425 Gene

GeneLoc Exon Structure for
MIR4425

No data available for mRNA/cDNA for MIR4425 Gene

Expression for MIR4425 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4425 Gene

genes like me logo Genes that share expression patterns with MIR4425: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4425 Gene

Orthologs for MIR4425 Gene

Evolution for MIR4425 Gene

ENSEMBL:
Gene Tree for MIR4425 (if available)
TreeFam:
Gene Tree for MIR4425 (if available)

No data available for Orthologs for MIR4425 Gene

Paralogs for MIR4425 Gene

No data available for Paralogs for MIR4425 Gene

Variants for MIR4425 Gene

Additional dbSNP identifiers (rs#s) for MIR4425 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4425 Gene

Variant ID Type Subtype PubMed ID
dgv132n100 CNV gain 25217958
esv3576582 CNV gain 25503493

Additional Variant Information for MIR4425 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4425

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4425 Gene

Disorders for MIR4425 Gene

No disorders were found for MIR4425 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4425 Gene

Publications for MIR4425 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4425 Gene

Sources for MIR4425 Gene