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Aliases for MIR4424 Gene

Subcategory (RNA class) for MIR4424 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR4424 Gene

  • MicroRNA 4424 2 3 5
  • Hsa-Mir-4424 3

External Ids for MIR4424 Gene

Previous GeneCards Identifiers for MIR4424 Gene

  • GC01U903280

Summaries for MIR4424 Gene

Entrez Gene Summary for MIR4424 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4424 Gene

MIR4424 (MicroRNA 4424) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4424 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4424 Gene

Genomics for MIR4424 Gene

GeneHancer (GH) Regulatory Elements for MIR4424 Gene

Promoters and enhancers for MIR4424 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I178682 Enhancer 0.9 ENCODE 0.8 +4.9 4892 0.2 FOXA2 MLX ARID4B SP5 MIER2 PPARG KAT8 NFIL3 MIER3 RCOR2 MIR4424 GC01P178687
GH01I178683 Enhancer 0.9 Ensembl ENCODE 0.4 +7.1 7109 2.9 JUN ZNF384 BATF IRF4 RARA RFX5 POLR2A RCOR1 ATF7 FOSL2 RALGPS2 GC01P178687 MIR4424
GH01I178660 Enhancer 0.7 ENCODE 0.4 -17.8 -17808 0.2 PKNOX1 SMAD1 BACH1 BMI1 IRF4 RELA FOXK2 ATF7 IKZF2 RUNX3 RALGPS2 ENSG00000273384 MIR4424
GH01I178659 Enhancer 0.6 ENCODE 0.4 -18.1 -18108 0.2 CBFB JUNB DPF2 ZNF217 FOXK2 IKZF1 MLLT1 IKZF2 ENSG00000273384 MIR4424
GH01I178650 Enhancer 0.8 Ensembl ENCODE 0.3 -25.5 -25508 3.4 RFX1 ZNF384 JUND POLR2A FOS HNF4A NR2F6 FOSL2 ENSG00000273384 GC01M178650 RALGPS2 C1orf220 ANGPTL1 MIR4424
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR4424 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4424 Gene

Genomic Locations for MIR4424 Gene
chr1:178,677,749-178,677,834
(GRCh38/hg38)
Size:
86 bases
Orientation:
Plus strand
chr1:178,646,884-178,646,969
(GRCh37/hg19)

Genomic View for MIR4424 Gene

Genes around MIR4424 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4424 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4424 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4424 Gene

Proteins for MIR4424 Gene

Post-translational modifications for MIR4424 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4424 Gene

Domains & Families for MIR4424 Gene

Gene Families for MIR4424 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4424: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4424 Gene

Function for MIR4424 Gene

Phenotypes From GWAS Catalog for MIR4424 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4424 Gene

Localization for MIR4424 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4424 Gene

Pathways & Interactions for MIR4424 Gene

SuperPathways for MIR4424 Gene

No Data Available

Interacting Proteins for MIR4424 Gene

Gene Ontology (GO) - Biological Process for MIR4424 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4424 Gene

Drugs & Compounds for MIR4424 Gene

No Compound Related Data Available

Transcripts for MIR4424 Gene

mRNA/cDNA for MIR4424 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4424 Gene

No ASD Table

Relevant External Links for MIR4424 Gene

GeneLoc Exon Structure for
MIR4424
ECgene alternative splicing isoforms for
MIR4424

Expression for MIR4424 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4424 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4424 Gene:

MIR4424
genes like me logo Genes that share expression patterns with MIR4424: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4424 Gene

Orthologs for MIR4424 Gene

Evolution for MIR4424 Gene

ENSEMBL:
Gene Tree for MIR4424 (if available)
TreeFam:
Gene Tree for MIR4424 (if available)

No data available for Orthologs for MIR4424 Gene

Paralogs for MIR4424 Gene

No data available for Paralogs for MIR4424 Gene

Variants for MIR4424 Gene

Sequence variations from dbSNP and Humsavar for MIR4424 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000130318 -- 178,677,139(+) C/A upstream_transcript_variant
rs1000418748 -- 178,676,793(+) G/A upstream_transcript_variant
rs1001123695 -- 178,678,298(+) A/G downstream_transcript_variant
rs1001131086 -- 178,677,198(+) T/A upstream_transcript_variant
rs1001531695 -- 178,678,335(+) A/T

Structural Variations from Database of Genomic Variants (DGV) for MIR4424 Gene

Variant ID Type Subtype PubMed ID
nsv548255 CNV loss 21841781
nsv548254 CNV gain 21841781
nsv466116 CNV loss 19166990
nsv437255 CNV loss 16327808

Additional Variant Information for MIR4424 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4424

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4424 Gene

Disorders for MIR4424 Gene

Additional Disease Information for MIR4424

No disorders were found for MIR4424 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4424 Gene

Publications for MIR4424 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3 58
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4424 Gene

Sources for MIR4424 Gene

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