microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4424 Gene

Subcategory (RNA class) for MIR4424 Gene

miRNA

Number of RNA Genes sources:

3 / 17

Aliases for MIR4424 Gene

  • MicroRNA 4424 2 3 5
  • Hsa-Mir-4424 2 3 178
  • MIR4424 2 5
  • Hsa-MiR-4424 173
  • MIMAT0018939 50
  • MI0016763 50

External Ids for MIR4424 Gene

Previous GeneCards Identifiers for MIR4424 Gene

  • GC01U903280

Summaries for MIR4424 Gene

Entrez Gene Summary for MIR4424 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4424 Gene

MIR4424 (MicroRNA 4424) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4424 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4424 Gene

Genomics for MIR4424 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4424 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J178682 Enhancer 1.1 Ensembl ENCODE 0.4 +6.7 6652 4.8 GATAD2A TFE3 SOX13 NFKBIZ RCOR2 RXRB IRF2 IKZF2 GABPA CEBPA RALGPS2 lnc-RALGPS2-4 MIR4424 TEX35
GH01J178664 Promoter/Enhancer 1 EPDnew Ensembl ENCODE 0.4 -12.2 -12248 3.8 YY1 CEBPB TCF12 NBN CEBPG SPI1 POLR2A RAD51 CTCF RALGPS2 C1orf220 CLEC20A ENSG00000273384 MIR4424 TEX35
GH01J178655 Enhancer 0.9 Ensembl ENCODE 0.4 -21.5 -21548 1.6 CEBPG CREB1 ZHX2 FOXA1 ATF7 SCRT2 CTBP1 CEBPB JUN ZNF217 C1orf220 RALGPS2 ENSG00000273384 MIR4424 TEX35
GH01J178649 Enhancer 0.9 Ensembl ENCODE CraniofacialAtlas 0.3 -25.9 -25890 4.1 RFX1 FOXA2 FOSL2 POLR2A HNF4A FOS SMARCA4 JUND NR2F6 ZNF384 ENSG00000273384 lnc-CLEC20A-4 RALGPS2 C1orf220 TEX35 ANGPTL1 MIR4424
GH01J178660 Enhancer 0.7 ENCODE 0.4 -17.8 -17808 0.2 BACH1 RELA IKZF2 RCOR1 TRIM22 PKNOX1 ARID3A DPF2 RELB RUNX3 RALGPS2 ENSG00000273384 MIR4424 TEX35
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4424 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4424 Gene

Genomic Locations for MIR4424 Gene
chr1:178,677,749-178,677,834
(GRCh38/hg38)
Size:
86 bases
Orientation:
Plus strand
chr1:178,646,884-178,646,969
(GRCh37/hg19)
Size:
86 bases
Orientation:
Plus strand

Genomic View for MIR4424 Gene

Genes around MIR4424 on UCSC Golden Path with GeneCards custom track
MIR4424 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4424 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4424 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4424 Gene

Proteins for MIR4424 Gene

Post-translational modifications for MIR4424 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4424 Gene

Domains & Families for MIR4424 Gene

Gene Families for MIR4424 Gene

HGNC:
genes like me logo Genes that share domains with MIR4424: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4424 Gene

Function for MIR4424 Gene

Phenotypes From GWAS Catalog for MIR4424 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4424 Gene

Localization for MIR4424 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4424 Gene

Pathways & Interactions for MIR4424 Gene

PathCards logo

SuperPathways for MIR4424 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4424 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4424 Gene

Drugs & Compounds for MIR4424 Gene

No Compound Related Data Available

Transcripts for MIR4424 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4424 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075CF8C_9606 precursor_RNA 86 4

HGNC: 41805,

RefSeq: NR_039622,

Ensembl: ENST00000585257 (view in UCSC) ,

miRBase: MI0016763,

URS000075A76A_9606 miRNA 22 4

RefSeq: NR_039622,

miRBase: MIMAT0018939,

MirGeneDB: Hsa-Mir-4424_5p,

TarBase: hsa-miR-4424,

URS0000EFE40F_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-4424,

URS0000EFF373_9606 miRNA 22 1

MirGeneDB: Hsa-Mir-4424_3p,

MIR4424 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4424 Gene

No ASD Table

Relevant External Links for MIR4424 Gene

GeneLoc Exon Structure for
MIR4424

No data available for mRNA/cDNA for MIR4424 Gene

Expression for MIR4424 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4424 Gene

genes like me logo Genes that share expression patterns with MIR4424: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4424 Gene

Orthologs for MIR4424 Gene

Evolution for MIR4424 Gene

ENSEMBL:
Gene Tree for MIR4424 (if available)
TreeFam:
Gene Tree for MIR4424 (if available)

No data available for Orthologs for MIR4424 Gene

Paralogs for MIR4424 Gene

No data available for Paralogs for MIR4424 Gene

Variants for MIR4424 Gene

Additional dbSNP identifiers (rs#s) for MIR4424 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4424 Gene

Variant ID Type Subtype PubMed ID
nsv437255 CNV loss 16327808
nsv466116 CNV loss 19166990
nsv548254 CNV gain 21841781
nsv548255 CNV loss 21841781

Additional Variant Information for MIR4424 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4424

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4424 Gene

Disorders for MIR4424 Gene

No disorders were found for MIR4424 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4424 Gene

Publications for MIR4424 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4424 Gene

Sources for MIR4424 Gene