microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4423 Gene

Subcategory (RNA class) for MIR4423 Gene

miRNA

Number of RNA Genes sources:

4 / 17

Aliases for MIR4423 Gene

  • MicroRNA 4423 2 3 5
  • Hsa-MiR-4423-3p 163 173
  • Hsa-MiR-4423-5p 163 173
  • Hsa-Mir-4423 2 3
  • MIR4423 2 5
  • MIMAT0018936 50
  • MIMAT0019232 50
  • MI0016760 50
  • Mir-4423 3

External Ids for MIR4423 Gene

Previous GeneCards Identifiers for MIR4423 Gene

  • GC01U903285
  • GC01P085602

Summaries for MIR4423 Gene

Entrez Gene Summary for MIR4423 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4423 Gene

MIR4423 (MicroRNA 4423) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4423 include Bronchus Cancer.

Additional gene information for MIR4423 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4423 Gene

Genomics for MIR4423 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4423 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J085132 Enhancer 0.9 Ensembl ENCODE 600.7 +0.8 807 5.6 CEBPG CREB1 GATAD2A FOXA1 RFX1 CEBPA ZBTB44 CEBPB EZH2 ZNF23 MIR4423 SYDE2 SPATA1 DNAI3 MCOLN2 ENSG00000280099 lnc-SYDE2-1 MCOLN3
GH01J085137 Enhancer 0.8 Ensembl ENCODE 0.7 +4.1 4107 0.6 REST SP1 FOXA2 YY1 GABPA ZBTB33 JUND NR2F2 RAD21 HNF4A MCOLN2 MIR4423 ENSG00000280099 lnc-SYDE2-1 SYDE2 MCOLN3
GH01J085148 Enhancer 0.8 FANTOM5 Ensembl 0.4 +15.3 15307 2.2 JUND RUNX3 BCLAF1 BCL11A JUNB IRF4 BATF EBF1 MTA2 SPI1 SYDE2 MCOLN2 DNAI3 ENSG00000280099 lnc-SYDE2-1 MIR4423 MCOLN3
GH01J085151 Enhancer 0.5 Ensembl 0.4 +17.9 17907 0.6 PRDM1 NR2F2 PRDM6 SMARCA4 NR2F6 NR2F1 ZNF384 PKNOX1 ENSG00000223653 MCOLN2 ENSG00000280099 lnc-SYDE2-1 MIR4423 SYDE2 MCOLN3
GH01J085153 Enhancer 0.5 Ensembl 0.4 +19.5 19507 0.6 PRDM1 SCRT2 ZNF316 ZBTB17 SCRT1 RFX5 ZFHX2 CREM ENSG00000280099 lnc-SYDE2-1 MIR4423 SYDE2 MCOLN3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4423 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4423 Gene

Genomic Locations for MIR4423 Gene
chr1:85,133,794-85,133,873
(GRCh38/hg38)
Size:
80 bases
Orientation:
Plus strand
chr1:85,599,477-85,599,556
(GRCh37/hg19)
Size:
80 bases
Orientation:
Plus strand

Genomic View for MIR4423 Gene

Genes around MIR4423 on UCSC Golden Path with GeneCards custom track
MIR4423 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4423 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4423 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4423 Gene

Proteins for MIR4423 Gene

Post-translational modifications for MIR4423 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4423 Gene

Domains & Families for MIR4423 Gene

Gene Families for MIR4423 Gene

HGNC:
genes like me logo Genes that share domains with MIR4423: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4423 Gene

Function for MIR4423 Gene

Phenotypes From GWAS Catalog for MIR4423 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4423 Gene

Localization for MIR4423 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR4423 gene
Compartment Confidence
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4423 Gene

Pathways & Interactions for MIR4423 Gene

PathCards logo

SuperPathways for MIR4423 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4423 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4423 Gene

Drugs & Compounds for MIR4423 Gene

No Compound Related Data Available

Transcripts for MIR4423 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4423 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075CEC2_9606 precursor_RNA 80 5

HGNC: 41784,

RefSeq: NR_039619,

Ensembl: ENST00000580922 (view in UCSC) ,

miRBase: MI0016760,

ENA: LM611284.1:1..80:precursor_RNA,

URS0000567AB1_9606 miRNA 22 5

RefSeq: NR_039619,

LncBase: hsa-miR-4423-5p,

miRBase: MIMAT0019232,

TarBase: hsa-miR-4423-5p,

ENA: FR772832.1:1..22:ncRNA, LM382504.1:1..22:ncRNA, LM611284.1:13..34:ncRNA,

URS00001481F9_9606 miRNA 21 5

RefSeq: NR_039619,

LncBase: hsa-miR-4423-3p,

miRBase: MIMAT0018936,

TarBase: hsa-miR-4423-3p,

ENA: LM382380.1:1..21:ncRNA, LM611284.1:49..69:ncRNA,

URS00005FE9BE_9606 miRNA 22 1

ENA: FR772831.1:1..22:ncRNA,

MIR4423 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR4423 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4423 Gene

No ASD Table

Relevant External Links for MIR4423 Gene

GeneLoc Exon Structure for
MIR4423

Expression for MIR4423 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4423 Gene

genes like me logo Genes that share expression patterns with MIR4423: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4423 Gene

Orthologs for MIR4423 Gene

Evolution for MIR4423 Gene

ENSEMBL:
Gene Tree for MIR4423 (if available)
TreeFam:
Gene Tree for MIR4423 (if available)

No data available for Orthologs for MIR4423 Gene

Paralogs for MIR4423 Gene

No data available for Paralogs for MIR4423 Gene

Variants for MIR4423 Gene

Additional dbSNP identifiers (rs#s) for MIR4423 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4423 Gene

Variant ID Type Subtype PubMed ID
esv34165 CNV loss 18971310
nsv830459 CNV loss 17160897

Additional Variant Information for MIR4423 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4423

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4423 Gene

Disorders for MIR4423 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR4423 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bronchus cancer
  • malignant neoplasm of bronchus and lung
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR4423: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR4423 Gene

Publications for MIR4423 Gene

  1. MicroRNA 4423 is a primate-specific regulator of airway epithelial cell differentiation and lung carcinogenesis. (PMID: 24158479) Perdomo C … Spira A (Proceedings of the National Academy of Sciences of the United States of America 2013) 3
  2. miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. (PMID: 21911355) Friedländer MR … Rajewsky N (Nucleic acids research 2012) 3
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  4. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  5. Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome. (PMID: 21807764) Joyce CE … Bowcock AM (Human molecular genetics 2011) 3

Products for MIR4423 Gene

Sources for MIR4423 Gene