microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4422 Gene

Data sources for MIR4422 Gene:

RNA type for MIR4422 Gene

miRNA

Aliases for MIR4422 Gene

External Ids for MIR4422 Gene

Previous GeneCards Identifiers for MIR4422 Gene

  • GC01U903282
  • GC01P055693

Summaries for MIR4422 Gene

Entrez Gene Summary for MIR4422 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4422 Gene

MIR4422 (MicroRNA 4422) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4422 include Epilepsy With Generalized Tonic-Clonic Seizures.

Additional gene information for MIR4422 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4422 Gene

Genomics for MIR4422 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4422 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J055225 Enhancer 0.2 Ensembl 250.7 -0.2 -240 0.4 HSALNG0003825 MIR4422 MIR4422HG USP24
GH01J055233 Enhancer 0.8 Ensembl 0.4 +8.3 8260 1.4 ZNF592 YY1 FOXA1 THAP11 FOXA2 RXRA SAP130 TEAD3 JUND FOSL2 piR-61945-024 USP24 MIR4422 MIR4422HG
GH01J055232 Enhancer 0.3 Ensembl 0.4 +7.1 7060 0.2 SCRT2 piR-61945-024 MIR4422 USP24 MIR4422HG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4422 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4422 Gene

Latest Assembly
chr1:55,225,641-55,225,723
(GRCh38/hg38)
Size:
83 bases
Orientation:
Plus strand

Previous Assembly
chr1:55,691,314-55,691,396
(GRCh37/hg19 by Entrez Gene)
Size:
83 bases
Orientation:
Plus strand

chr1:55,691,314-55,691,396
(GRCh37/hg19 by Ensembl)
Size:
83 bases
Orientation:
Plus strand

Genomic View for MIR4422 Gene

Genes around MIR4422 on UCSC Golden Path with GeneCards custom track
MIR4422 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR4422 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4422 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4422 Gene

Proteins for MIR4422 Gene

Post-translational modifications for MIR4422 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4422 Gene

Domains & Families for MIR4422 Gene

Gene Families for MIR4422 Gene

HGNC:
genes like me logo Genes that share domains with MIR4422: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4422 Gene

Function for MIR4422 Gene

Phenotypes From GWAS Catalog for MIR4422 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4422 Gene

Localization for MIR4422 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4422 Gene

Pathways & Interactions for MIR4422 Gene

PathCards logo

SuperPathways for MIR4422 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4422 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4422 Gene

Drugs & Compounds for MIR4422 Gene

No Compound Related Data Available

Transcripts for MIR4422 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4422 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00005606AA_9606 miRNA 21 5

RefSeq: NR_039618,

LncBase: hsa-miR-4422,

miRBase: MIMAT0018935,

TarBase: hsa-miR-4422,

ENA: FR772830.1:1..21:ncRNA, LM382379.1:1..21:ncRNA, LM611283.1:16..36:ncRNA,

URS000075B2A4_9606 precursor_RNA 83 4

RefSeq: NR_039618,

Ensembl: ENST00000581938 (view in UCSC) ,

miRBase: MI0016759,

ENA: LM611283.1:1..83:precursor_RNA,

MIR4422 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR4422 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4422 Gene

No ASD Table

Relevant External Links for MIR4422 Gene

GeneLoc Exon Structure for
MIR4422

Expression for MIR4422 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4422 Gene

genes like me logo Genes that share expression patterns with MIR4422: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4422 Gene

Orthologs for MIR4422 Gene

Evolution for MIR4422 Gene

ENSEMBL:
Gene Tree for MIR4422 (if available)
TreeFam:
Gene Tree for MIR4422 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR4422

No data available for Orthologs for MIR4422 Gene

Paralogs for MIR4422 Gene

No data available for Paralogs for MIR4422 Gene

Variants for MIR4422 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR4422 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR4422 Gene

Variant ID Type Subtype PubMed ID
nsv817614 CNV gain 22305530
nsv945962 CNV duplication 23825009

Additional Variant Information for MIR4422 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4422
Leiden Open Variation Database (LOVD)
MIR4422

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4422 Gene

Disorders for MIR4422 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR4422 Gene - From: COP

Disorder Aliases PubMed IDs
epilepsy with generalized tonic-clonic seizures
  • epileptic seizures, tonic-clonic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR4422

genes like me logo Genes that share disorders with MIR4422: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR4422 Gene

Publications for MIR4422 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H … Rovira C (Cancer research 2011) 3
  3. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4422 Gene

Sources for MIR4422 Gene