microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4418 Gene

Subcategory (RNA class) for MIR4418 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR4418 Gene

  • MicroRNA 4418 2 3 5
  • Hsa-Mir-4418 2 3
  • MIR4418 2 5
  • MIMAT0018930 50
  • MI0016754 50

External Ids for MIR4418 Gene

Previous GeneCards Identifiers for MIR4418 Gene

  • GC01U903287
  • GC01P022593

Summaries for MIR4418 Gene

Entrez Gene Summary for MIR4418 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4418 Gene

MIR4418 (MicroRNA 4418) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4418 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4418 Gene

Genomics for MIR4418 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4418 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J022266 Enhancer 0.4 Ensembl 600.7 +0.2 162 0.8 ZFHX2 GLIS1 EGR2 MIR4418 LINC00339 HSALNG0001578 WNT4 ZBTB40
GH01J022250 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -8.1 -8139 15.4 ZBTB33 TEAD4 RFX1 KDM1A FOXA1 ZIC2 ZNF776 ZSCAN4 MTA1 PATZ1 KDM1A NBPF2P USP48 NBPF3 LINC00339 HSPG2 MIR4418 LOC107985377 lnc-CDC42-1 WNT4
GH01J022273 Enhancer 0.9 Ensembl ENCODE 0.4 +8.1 8102 3.9 HNRNPL CTCF ZBTB33 PATZ1 REST RAD21 ZNF24 ZNF600 ATF7 ZNF444 WNT4 LUZP1 MIR4418 HSALNG0001578 ZBTB40
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4418 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4418 Gene

Genomic Locations for MIR4418 Gene
chr1:22,266,239-22,266,300
(GRCh38/hg38)
Size:
62 bases
Orientation:
Plus strand
chr1:22,592,732-22,592,793
(GRCh37/hg19)
Size:
62 bases
Orientation:
Plus strand

Genomic View for MIR4418 Gene

Genes around MIR4418 on UCSC Golden Path with GeneCards custom track
MIR4418 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4418 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4418 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4418 Gene

Proteins for MIR4418 Gene

Post-translational modifications for MIR4418 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4418 Gene

Domains & Families for MIR4418 Gene

Gene Families for MIR4418 Gene

HGNC:
genes like me logo Genes that share domains with MIR4418: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4418 Gene

Function for MIR4418 Gene

Phenotypes From GWAS Catalog for MIR4418 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4418 Gene

Localization for MIR4418 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4418 Gene

Pathways & Interactions for MIR4418 Gene

PathCards logo

SuperPathways for MIR4418 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4418 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4418 Gene

Drugs & Compounds for MIR4418 Gene

No Compound Related Data Available

Transcripts for MIR4418 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4418 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075C3AB_9606 precursor_RNA 62 4

HGNC: 41789,

RefSeq: NR_039613,

Ensembl: ENST00000581169 (view in UCSC) ,

miRBase: MI0016754,

URS000075ADC1_9606 miRNA 18 2

RefSeq: NR_039613,

miRBase: MIMAT0018930,

MIR4418 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4418 Gene

No ASD Table

Relevant External Links for MIR4418 Gene

GeneLoc Exon Structure for
MIR4418

No data available for mRNA/cDNA for MIR4418 Gene

Expression for MIR4418 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4418 Gene

Orthologs for MIR4418 Gene

Evolution for MIR4418 Gene

ENSEMBL:
Gene Tree for MIR4418 (if available)
TreeFam:
Gene Tree for MIR4418 (if available)

No data available for Orthologs for MIR4418 Gene

Paralogs for MIR4418 Gene

No data available for Paralogs for MIR4418 Gene

Variants for MIR4418 Gene

Additional dbSNP identifiers (rs#s) for MIR4418 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4418 Gene

Variant ID Type Subtype PubMed ID
esv3585465 CNV loss 21293372
esv3585467 CNV loss 21293372
nsv516575 CNV loss 19592680

Additional Variant Information for MIR4418 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4418

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4418 Gene

Disorders for MIR4418 Gene

No disorders were found for MIR4418 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4418 Gene

Publications for MIR4418 Gene

  1. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

No data available for Mastermind for MIR4418 Gene

Products for MIR4418 Gene

Sources for MIR4418 Gene