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Aliases for MIR433 Gene

Subcategory (RNA class) for MIR433 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR433 Gene

  • MicroRNA 433 2 3 5
  • Hsa-Mir-433 3
  • MiRNA433 3
  • Mir-433 3
  • MIRN433 3

External Ids for MIR433 Gene

ORGUL Members for MIR433 Gene

Previous HGNC Symbols for MIR433 Gene

  • MIRN433

Previous GeneCards Identifiers for MIR433 Gene

  • GC14P100464
  • GC14P100847
  • GC14P101348
  • GC14P101056
  • GC14P101281
  • GC14P101910
  • GC14P102219
  • GC14P102386
  • GC14P102564
  • GC14P102737
  • GC14P102910

Summaries for MIR433 Gene

Entrez Gene Summary for MIR433 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR433 Gene

MIR433 (MicroRNA 433) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR433 include Parkinson Disease, Late-Onset and Systemic Lupus Erythematosus. Among its related pathways are Parkinsons Disease Pathway and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Additional gene information for MIR433 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR433 Gene

Genomics for MIR433 Gene

GeneHancer (GH) Regulatory Elements for MIR433 Gene

Promoters and enhancers for MIR433 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J100880 Enhancer 0.2 ENCODE 650.7 -1.0 -1045 1 GC14P103389 GC14P103408 MIR431 MIR433 RTL1 MIR665 ENSG00000258399
GH14J100819 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -55.4 -55350 13.4 ELF3 PKNOX1 FOXA2 ZSCAN4 NFXL1 ZNF48 RAD21 RFX5 ZNF280A SLC30A9 ENSG00000274884 DLK1 MEG3 MIR493 MIR337 MIR431 MIR127 MIR136 MIR433 RTL1
GH14J100691 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10 -188.5 -188469 4.1 FOXA2 MLX SIN3A ZNF48 ETS1 YY1 GLIS2 ZNF143 FOS SP5 DLK1 MIR493 MIR337 MIR127 MIR431 MIR433 MIR136 RTL1 LINC00523 LOC105370668
GH14J100486 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 8.8 -395.4 -395447 0.6 ARID4B SIN3A FEZF1 ZNF2 ZNF48 ZNF143 ATF7 RUNX3 JUNB MXD4 RN7SKP92 MIR337 MIR127 MIR136 MIR433 RTL1 MIR431 MIR493 GC14P103466 GC14M100431
GH14J100657 Enhancer 1.4 Ensembl ENCODE dbSUPER 9.6 -217.4 -217375 13.4 ATF1 FOXA2 ARID4B DMAP1 ZNF2 ZNF48 ZNF143 ATF7 FOS RXRA LOC105370667 DLK1 WARS WDR25 BEGAIN MEG9 MIR493 MIR337 MIR127 MIR431
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR433 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR433 Gene

Genomic Locations for MIR433 Gene
chr14:100,881,886-100,881,978
(GRCh38/hg38)
Size:
93 bases
Orientation:
Plus strand
chr14:101,348,220-101,348,343
(GRCh37/hg19)
Size:
124 bases
Orientation:
Plus strand

Genomic View for MIR433 Gene

Genes around MIR433 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR433 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR433 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR433 Gene

Proteins for MIR433 Gene

Post-translational modifications for MIR433 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR433 Gene

Domains & Families for MIR433 Gene

Gene Families for MIR433 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR433: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR433 Gene

Function for MIR433 Gene

Phenotypes From GWAS Catalog for MIR433 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR433 Gene

Localization for MIR433 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR433 Gene

Pathways & Interactions for MIR433 Gene

genes like me logo Genes that share pathways with MIR433: view

Pathways by source for MIR433 Gene

2 BioSystems pathways for MIR433 Gene

Interacting Proteins for MIR433 Gene

Gene Ontology (GO) - Biological Process for MIR433 Gene

None

No data available for SIGNOR curated interactions for MIR433 Gene

Drugs & Compounds for MIR433 Gene

No Compound Related Data Available

Transcripts for MIR433 Gene

mRNA/cDNA for MIR433 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR433 Gene

No ASD Table

Relevant External Links for MIR433 Gene

GeneLoc Exon Structure for
MIR433
ECgene alternative splicing isoforms for
MIR433

Expression for MIR433 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR433 Gene

mRNA differential expression in normal tissues according to GTEx for MIR433 Gene

This gene is overexpressed in Brain - Hypothalamus (x31.6) and Brain - Substantia nigra (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of MIR433 Gene:

MIR433
genes like me logo Genes that share expression patterns with MIR433: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR433 Gene

Orthologs for MIR433 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR433 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-433 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-433 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir433 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-433 34
  • 97 (a)
OneToOne
Species where no ortholog for MIR433 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR433 Gene

ENSEMBL:
Gene Tree for MIR433 (if available)
TreeFam:
Gene Tree for MIR433 (if available)

Paralogs for MIR433 Gene

No data available for Paralogs for MIR433 Gene

Variants for MIR433 Gene

Sequence variations from dbSNP and Humsavar for MIR433 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000267233 -- 100,880,894(+) T/A upstream_transcript_variant
rs1000317571 -- 100,881,905(+) G/A non_coding_transcript_variant
rs1002522085 -- 100,880,636(+) G/A upstream_transcript_variant
rs1003148534 -- 100,882,423(+) A/T downstream_transcript_variant
rs1004495568 -- 100,880,628(+) T/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR433 Gene

Variant ID Type Subtype PubMed ID
nsv509549 CNV insertion 20534489
esv3635518 CNV gain 21293372

Additional Variant Information for MIR433 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR433

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR433 Gene

Disorders for MIR433 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR433 Gene - From: miR2Disease

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR433

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR433: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR433 Gene

Publications for MIR433 Gene

  1. FGF20 rs12720208 SNP and microRNA-433 variation: no association with Parkinson's disease in Spanish patients. (PMID: 20471450) de Mena L … Alvarez V (Neuroscience letters 2010) 3 44 58
  2. MicroRNA-433 Inhibits the Proliferation and Migration of HUVECs and Neurons by Targeting Hypoxia-Inducible Factor 1 Alpha. (PMID: 27815672) Zhang L … Liu Y (Journal of molecular neuroscience : MN 2017) 3 58
  3. MiR-433-3p suppresses cell growth and enhances chemosensitivity by targeting CREB in human glioma. (PMID: 27926502) Sun S … Wang J (Oncotarget 2017) 3 58
  4. MicroRNA-433-3p promotes osteoblast differentiation through targeting DKK1 expression. (PMID: 28628652) Tang X … Lu J (PloS one 2017) 3 58
  5. MiR-433 inhibits retinoblastoma malignancy by suppressing Notch1 and PAX6 expression. (PMID: 27470361) Li X … Wang R (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016) 3 58

Products for MIR433 Gene

Sources for MIR433 Gene

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