microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4324 Gene

Subcategory (RNA class) for MIR4324 Gene

miRNA

Number of RNA Genes sources:

2 / 17

Aliases for MIR4324 Gene

  • MicroRNA 4324 2 3 5
  • Hsa-Mir-4324 2 3
  • MIR4324 2 5
  • MIMAT0016876 50
  • MI0015854 50
  • Mir-4324 3

External Ids for MIR4324 Gene

Previous GeneCards Identifiers for MIR4324 Gene

  • GC19U901377
  • GC19M049812

Summaries for MIR4324 Gene

Entrez Gene Summary for MIR4324 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4324 Gene

MIR4324 (MicroRNA 4324) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4324 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4324 Gene

Genomics for MIR4324 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4324 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J049308 Enhancer 0.4 Ensembl 600.7 0.0 -33 1 RFX1 SCRT2 CTCF MIR4324 MN298721-001 DKKL1 piR-50443-204 SLC6A16 TRPM4
GH19J049309 Enhancer 0.4 Ensembl 600.7 -1.1 -1133 0.8 IKZF1 PRDM1 SCRT2 MIR4324 MN298721-001 piR-50443-204 SLC6A16 TRPM4
GH19J049318 Promoter 0.4 EPDnew 0.4 -9.9 -9861 0.1 ZNF26 SLC6A16 ADM5 PIH1D1 IRF3 GRWD1 SNORD35A SNORD35B PRR12 piR-50443-204 MIR4324
GH19J049316 Enhancer 0.4 Ensembl 0.4 -7.5 -7533 0.4 SCRT2 RUNX3 SCRT1 MIR4324 piR-50443-204 SLC6A16 TRPM4
GH19J049321 Enhancer 0.3 Ensembl dbSUPER 0.4 -13.0 -13033 0.2 piR-50443-204 PTH2 SLC17A7 SLC6A16 MIR4324 TRPM4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4324 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4324 Gene

Genomic Locations for MIR4324 Gene
chr19:49,308,797-49,308,868
(GRCh38/hg38)
Size:
72 bases
Orientation:
Minus strand
chr19:49,812,054-49,812,125
(GRCh37/hg19)
Size:
72 bases
Orientation:
Minus strand

Genomic View for MIR4324 Gene

Genes around MIR4324 on UCSC Golden Path with GeneCards custom track
MIR4324 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4324 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4324 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4324 Gene

Proteins for MIR4324 Gene

Post-translational modifications for MIR4324 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4324 Gene

Domains & Families for MIR4324 Gene

Gene Families for MIR4324 Gene

HGNC:
genes like me logo Genes that share domains with MIR4324: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4324 Gene

Function for MIR4324 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4324 Gene

Localization for MIR4324 Gene

Gene Ontology (GO) - Cellular Components for MIR4324 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR4324: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR4324 Gene

Pathways & Interactions for MIR4324 Gene

PathCards logo

SuperPathways for MIR4324 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4324 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4324 Gene

Drugs & Compounds for MIR4324 Gene

No Compound Related Data Available

Transcripts for MIR4324 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4324 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075C737_9606 precursor_RNA 72 5

HGNC: 38392,

RefSeq: NR_036209,

Ensembl: ENST00000584846 (view in UCSC) ,

miRBase: MI0015854,

ENA: LM611152.1:1..72:precursor_RNA,

URS000030F801_9606 miRNA 20 3

RefSeq: NR_036209,

miRBase: MIMAT0016876,

ENA: LM381841.1:1..20:ncRNA, LM611152.1:43..62:ncRNA,

MIR4324 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR4324 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4324 Gene

No ASD Table

Relevant External Links for MIR4324 Gene

GeneLoc Exon Structure for
MIR4324

Expression for MIR4324 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR4324 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR4324

genes like me logo Genes that share expression patterns with MIR4324: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4324 Gene

Orthologs for MIR4324 Gene

Evolution for MIR4324 Gene

ENSEMBL:
Gene Tree for MIR4324 (if available)
TreeFam:
Gene Tree for MIR4324 (if available)

No data available for Orthologs for MIR4324 Gene

Paralogs for MIR4324 Gene

No data available for Paralogs for MIR4324 Gene

Variants for MIR4324 Gene

Additional dbSNP identifiers (rs#s) for MIR4324 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4324 Gene

Variant ID Type Subtype PubMed ID
dgv52n68 CNV loss 17160897
nsv9739 CNV gain+loss 18304495

Additional Variant Information for MIR4324 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4324

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4324 Gene

Disorders for MIR4324 Gene

No disorders were found for MIR4324 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4324 Gene

Publications for MIR4324 Gene

  1. Full sequence of mutant huntingtin 3'-untranslated region and modulation of its gene regulatory activity by endogenous microRNA. (PMID: 31296921) Kim KH … Lee JM (Journal of human genetics 2019) 3
  2. Identification of the novel 3' UTR sequences of human IL-21 mRNA as potential targets of miRNAs. (PMID: 28798470) Enomoto Y … Miyajima A (Scientific reports 2017) 3
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  4. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff LA … Hart RP (PloS one 2009) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4324 Gene

Sources for MIR4324 Gene