microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4321 Gene

Subcategory (RNA class) for MIR4321 Gene

miRNA

Number of RNA Genes sources:

1 / 17

Aliases for MIR4321 Gene

  • MicroRNA 4321 2 3 5
  • Hsa-Mir-4321 2 3
  • MIR4321 2 5
  • MIMAT0016874 50
  • MI0015852 50

External Ids for MIR4321 Gene

Previous GeneCards Identifiers for MIR4321 Gene

  • GC19U901368
  • GC19P002249

Summaries for MIR4321 Gene

Entrez Gene Summary for MIR4321 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4321 Gene

MIR4321 (MicroRNA 4321) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR4321 include Persistent Mullerian Duct Syndrome and Mullerian Aplasia And Hyperandrogenism. Among its related pathways are Mesodermal Commitment Pathway.

Additional gene information for MIR4321 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4321 Gene

Genomics for MIR4321 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4321 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J002250 Promoter 0.7 Ensembl 600.7 +0.1 62 0.2 HNRNPL ZNF600 POLR2A KLF8 HIC1 SUPT5H RARA ZBTB33 ZFP37 NR2F6 AMH MIR4321 piR-35674-239 OAZ1
GH19J002252 Promoter 0.7 Ensembl 600.7 +1.3 1262 1.8 HNRNPL RBFOX2 POLR2A RNF2 TFDP1 ZNF792 GABPB1 KDM1A MXD3 EZH2 MIR4321 AMH piR-35674-239 JSRP1 OAZ1
GH19J002249 Promoter 0.7 EPDnew 600.7 -1.3 -1334 0.1 POLR2A ZBED1 BCL11A HIC1 SUPT5H BCL11B GLIS1 GLIS2 PML AMH MIR4321 NONHSAG024424.2 PLEKHJ1
GH19J002248 Enhancer 0.5 Ensembl 600.7 -1.8 -1838 0.4 ZNF341 SCRT2 POLR2A ZKSCAN1 SCRT1 ZFHX2 ZFP69B FEZF1 EGR2 AMH MIR4321 PLEKHJ1 NONHSAG024424.2 SF3A2
GH19J002254 Promoter/Enhancer 1.1 Ensembl ENCODE 0.7 +3.1 3097 1.1 HNRNPL GATAD2A CTCF TFE3 RXRB PATZ1 RAD21 IRF2 EZH2 GABPA THOP1 AMH MIR4321 piR-35674-239 JSRP1 OAZ1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4321 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4321 Gene

Genomic Locations for MIR4321 Gene
chr19:2,250,639-2,250,718
(GRCh38/hg38)
Size:
80 bases
Orientation:
Plus strand
chr19:2,250,638-2,250,717
(GRCh37/hg19)
Size:
80 bases
Orientation:
Plus strand

Genomic View for MIR4321 Gene

Genes around MIR4321 on UCSC Golden Path with GeneCards custom track
MIR4321 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR4321 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4321 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4321 Gene

Proteins for MIR4321 Gene

Post-translational modifications for MIR4321 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4321 Gene

Domains & Families for MIR4321 Gene

Gene Families for MIR4321 Gene

HGNC:
genes like me logo Genes that share domains with MIR4321: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4321 Gene

Function for MIR4321 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4321 Gene

Localization for MIR4321 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4321 Gene

Pathways & Interactions for MIR4321 Gene

PathCards logo

SuperPathways for MIR4321 Gene

SuperPathway Contained pathways
1 Mesodermal Commitment Pathway
genes like me logo Genes that share pathways with MIR4321: view

Pathways by source for MIR4321 Gene

1 BioSystems pathway for MIR4321 Gene

Gene Ontology (GO) - Biological Process for MIR4321 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR4321 Gene

Drugs & Compounds for MIR4321 Gene

No Compound Related Data Available

Transcripts for MIR4321 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4321 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075E6AC_9606 precursor_RNA 80 4

HGNC: 38244,

RefSeq: NR_036207,

Ensembl: ENST00000592276 (view in UCSC) ,

miRBase: MI0015852,

URS000075C164_9606 miRNA 21 2

RefSeq: NR_036207,

miRBase: MIMAT0016874,

MIR4321 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4321 Gene

No ASD Table

Relevant External Links for MIR4321 Gene

GeneLoc Exon Structure for
MIR4321

No data available for mRNA/cDNA for MIR4321 Gene

Expression for MIR4321 Gene

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4321 Gene

Orthologs for MIR4321 Gene

Evolution for MIR4321 Gene

ENSEMBL:
Gene Tree for MIR4321 (if available)
TreeFam:
Gene Tree for MIR4321 (if available)

No data available for Orthologs for MIR4321 Gene

Paralogs for MIR4321 Gene

No data available for Paralogs for MIR4321 Gene

Variants for MIR4321 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR4321 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs104894666 Pathogenic: Persistent mullerian duct syndrome, type I 2,250,667(+) C/T NONSENSE,NON_CODING_TRANSCRIPT_VARIANT
rs558720829 Uncertain Significance: not provided 2,250,712(+) G/C MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT

Additional dbSNP identifiers (rs#s) for MIR4321 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4321 Gene

Variant ID Type Subtype PubMed ID
dgv6218n54 CNV loss 21841781
nsv578382 CNV loss 21841781
nsv578383 CNV loss 21841781
nsv833707 CNV loss 17160897

Additional Variant Information for MIR4321 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4321

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4321 Gene

Disorders for MIR4321 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR4321 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
persistent mullerian duct syndrome
  • pmds
mullerian aplasia and hyperandrogenism
  • mullerian duct failure and hyperandrogenism
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR4321

genes like me logo Genes that share disorders with MIR4321: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR4321 Gene

Publications for MIR4321 Gene

  1. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff LA … Hart RP (PloS one 2009) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4321 Gene

Sources for MIR4321 Gene