microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR432 Gene

Subcategory (RNA class) for MIR432 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR432 Gene

  • MIMAT0002815 50
  • MIMAT0002814 50
  • MI0003133 50
  • MIRN432 3
  • Mir-432 3
  • RF00775 168

External Ids for MIR432 Gene

Previous HGNC Symbols for MIR432 Gene

  • MIRN432

Previous GeneCards Identifiers for MIR432 Gene

  • GC14P100484
  • GC14P100860
  • GC14P101350
  • GC14P101075
  • GC14P101286
  • GC14P103471
  • GC14P103661
  • GC14P103873
  • GC14P104254
  • GC14P101915
  • GC14P102223
  • GC14P102390
  • GC14P102570
  • GC14P102741
  • GC14P102915
  • GC14P103092
  • GC14P103289

Summaries for MIR432 Gene

Entrez Gene Summary for MIR432 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR432 Gene

MIR432 (MicroRNA 432) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR432 include Ovarian Cancer and Autism Spectrum Disorder.

Rfam classification for MIR432 Gene

Additional gene information for MIR432 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR432 Gene

Genomics for MIR432 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR432 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J100883 Enhancer 0.4 ENCODE dbSUPER 600.7 +0.4 350 2.8 ZKSCAN1 MIR127 MIR136 MIR432 MEG3 MIR370 SNORD113-1 SNORD113-2 PPP2R5C MEG8 RTL1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR432 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR432 Gene

Genomic Locations for MIR432 Gene
chr14:100,884,483-100,884,576
(GRCh38/hg38)
Size:
94 bases
Orientation:
Plus strand
chr14:101,350,820-101,350,913
(GRCh37/hg19)
Size:
94 bases
Orientation:
Plus strand

Genomic View for MIR432 Gene

Genes around MIR432 on UCSC Golden Path with GeneCards custom track
MIR432 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR432 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR432 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR432 Gene

Proteins for MIR432 Gene

Post-translational modifications for MIR432 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR432 Gene

Domains & Families for MIR432 Gene

Gene Families for MIR432 Gene

HGNC:
genes like me logo Genes that share domains with MIR432: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR432 Gene

Function for MIR432 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR432 Gene

Localization for MIR432 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR432 gene
Compartment Confidence
cytoskeleton 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MIR432 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR432: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR432 Gene

Pathways & Interactions for MIR432 Gene

PathCards logo

SuperPathways for MIR432 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR432 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR432: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR432 Gene

Drugs & Compounds for MIR432 Gene

No Compound Related Data Available

Transcripts for MIR432 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR432 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00006284D8_9606 precursor_RNA 94 6

HGNC: 32083,

RefSeq: NR_030173,

Ensembl: ENST00000606207 (view in UCSC) ,

miRBase: MI0003133,

Rfam: RF00775,

ENA: LM609463.1:1..94:precursor_RNA,

URS00001C406A_9606 miRNA 23 6

RefSeq: NR_030173,

LncBase: hsa-miR-432-5p,

miRBase: MIMAT0002814,

MirGeneDB: Hsa-Mir-432_5p,

TarBase: hsa-miR-432-5p,

ENA: AY785934.1:1..23:ncRNA, LM379772.1:1..23:ncRNA, LM609463.1:14..36:ncRNA,

URS0000105D19_9606 miRNA 21 5

RefSeq: NR_030173,

LncBase: hsa-miR-432-3p,

miRBase: MIMAT0002815,

TarBase: hsa-miR-432-3p,

ENA: AY940862.1:1..21:ncRNA, LM609463.1:62..82:ncRNA,

URS0000EFC395_9606 precursor_RNA 70 1

MirGeneDB: Hsa-Mir-432,

URS00007E4556_9606 miRNA 22 1

MirGeneDB: Hsa-Mir-432_3p,

MIR432 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR432 Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR432 Gene

No ASD Table

Relevant External Links for MIR432 Gene

GeneLoc Exon Structure for
MIR432

Expression for MIR432 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR432 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR432

genes like me logo Genes that share expression patterns with MIR432: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR432 Gene

Orthologs for MIR432 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR432 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-432 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-432 31
  • 94 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-432 31
  • 91 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir432 31
  • 63 (a)
OneToOne
Species where no ortholog for MIR432 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR432 Gene

ENSEMBL:
Gene Tree for MIR432 (if available)
TreeFam:
Gene Tree for MIR432 (if available)

Paralogs for MIR432 Gene

No data available for Paralogs for MIR432 Gene

Variants for MIR432 Gene

Additional dbSNP identifiers (rs#s) for MIR432 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR432 Gene

Variant ID Type Subtype PubMed ID
esv3635518 CNV gain 21293372
nsv509549 CNV insertion 20534489

Additional Variant Information for MIR432 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR432

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR432 Gene

Disorders for MIR432 Gene

MalaCards: The human disease database

(12) MalaCards diseases for MIR432 Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
ovarian cancer
  • ovarian cancer, somatic
autism spectrum disorder
  • asd
nemaline myopathy
  • nm
muscular dystrophy, duchenne type
  • dmd
chromosome 13q14 deletion syndrome
  • chromosome 13q deletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR432

genes like me logo Genes that share disorders with MIR432: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR432 Gene

Publications for MIR432 Gene

  1. ZFAS1 knockdown inhibits viability and enhances cisplatin cytotoxicity by up-regulating miR-432-5p in glioma cells. (PMID: 31246330) Yang G … Feng T (Basic & clinical pharmacology & toxicology 2019) 3
  2. Circular RNA hsa_circ_0008039 promotes breast cancer cell proliferation and migration by regulating miR-432-5p/E2F3 axis. (PMID: 29807010) Liu Y … Sun L (Biochemical and biophysical research communications 2018) 3
  3. Overexpression of circular RNA circ_001569 indicates poor prognosis in hepatocellular carcinoma and promotes cell growth and metastasis by sponging miR-411-5p and miR-432-5p. (PMID: 30086881) Liu H … Yang X (Biochemical and biophysical research communications 2018) 3
  4. miR-432 Induces NRF2 Stabilization by Directly Targeting KEAP1. (PMID: 28760781) Akdemir B … Inoue J (Molecular cancer research : MCR 2017) 3
  5. LncRNA625 modulates prostate cancer cells proliferation and apoptosis through regulating the Wnt/β-catenin pathway by targeting miR-432. (PMID: 28678327) Li JB … Yu LJ (European review for medical and pharmacological sciences 2017) 3

Products for MIR432 Gene

Sources for MIR432 Gene