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Aliases for MIR4319 Gene

Subcategory (RNA class) for MIR4319 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR4319 Gene

  • MicroRNA 4319 2 3 5
  • Hsa-Mir-4319 3

External Ids for MIR4319 Gene

Previous GeneCards Identifiers for MIR4319 Gene

  • GC18U900573
  • GC18M042550

Summaries for MIR4319 Gene

Entrez Gene Summary for MIR4319 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4319 Gene

MIR4319 (MicroRNA 4319) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4319 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR4319 Gene

Genomics for MIR4319 Gene

GeneHancer (GH) Regulatory Elements for MIR4319 Gene

Promoters and enhancers for MIR4319 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J044970 Enhancer 0.6 Ensembl ENCODE 600.7 +0.8 766 1.6 FOXA2 FOXA1 CTCF MIR4319 GC18M044779 SETBP1
GH18J044937 Enhancer 1 UCNEbase ENCODE 0.3 +31.4 31418 1.6 PRDM1 PRDM10 ZIC2 ZSCAN4 ZNF140 ZXDB OSR2 ZNF189 RCOR1 FEZF1 MIR4319 GC18M044779 SETBP1
GH18J044945 Enhancer 0.9 Ensembl 0.3 +24.0 23965 1.6 ZSCAN21 SP7 MZF1 ZNF488 ZBTB8A ZNF600 PRDM10 ZIC2 ZEB2 ZNF639 MIR4319 GC18M044779 SETBP1
GH18J044974 Enhancer 0.4 Ensembl 0.7 -4.2 -4235 0.4 RUNX3 JUNB MIR4319 ENSG00000279319 SETBP1
GH18J044942 Enhancer 0.7 Ensembl ENCODE 0.3 +27.5 27465 4.2 SP1 ZIC2 FOXA2 RAD21 MAFK GLIS1 FOXA1 SETBP1 MIR4319 GC18M044779
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4319 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4319 Gene

Genomic Locations for MIR4319 Gene
chr18:44,970,082-44,970,166
(GRCh38/hg38)
Size:
85 bases
Orientation:
Minus strand
chr18:42,550,047-42,550,131
(GRCh37/hg19)
Size:
85 bases
Orientation:
Minus strand

Genomic View for MIR4319 Gene

Genes around MIR4319 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4319 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4319 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4319 Gene

Proteins for MIR4319 Gene

Post-translational modifications for MIR4319 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4319 Gene

Domains & Families for MIR4319 Gene

Gene Families for MIR4319 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR4319: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR4319 Gene

Function for MIR4319 Gene

Phenotypes From GWAS Catalog for MIR4319 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4319 Gene

Localization for MIR4319 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4319 Gene

Pathways & Interactions for MIR4319 Gene

PathCards logo

SuperPathways for MIR4319 Gene

No Data Available

Interacting Proteins for MIR4319 Gene

Gene Ontology (GO) - Biological Process for MIR4319 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR4319 Gene

Drugs & Compounds for MIR4319 Gene

No Compound Related Data Available

Transcripts for MIR4319 Gene

mRNA/cDNA for MIR4319 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNA Central transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4319 Gene

No ASD Table

Relevant External Links for MIR4319 Gene

GeneLoc Exon Structure for
MIR4319
ECgene alternative splicing isoforms for
MIR4319

Expression for MIR4319 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR4319 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR4319 Gene:

MIR4319
genes like me logo Genes that share expression patterns with MIR4319: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4319 Gene

Orthologs for MIR4319 Gene

Evolution for MIR4319 Gene

ENSEMBL:
Gene Tree for MIR4319 (if available)
TreeFam:
Gene Tree for MIR4319 (if available)

No data available for Orthologs for MIR4319 Gene

Paralogs for MIR4319 Gene

No data available for Paralogs for MIR4319 Gene

Variants for MIR4319 Gene

Sequence variations from dbSNP and Humsavar for MIR4319 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000074263 -- 44,970,883(-) A/G upstream_transcript_variant
rs1001233238 -- 44,970,383(-) G/C upstream_transcript_variant
rs1001287314 -- 44,970,644(-) T/C upstream_transcript_variant
rs1006260420 -- 44,971,387(-) A/G upstream_transcript_variant
rs1006314149 -- 44,971,595(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR4319 Gene

Variant ID Type Subtype PubMed ID
nsv833637 CNV gain 17160897

Additional Variant Information for MIR4319 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4319

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR4319 Gene

Disorders for MIR4319 Gene

Additional Disease Information for MIR4319

No disorders were found for MIR4319 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4319 Gene

Publications for MIR4319 Gene

  1. Re-expression of microRNA-4319 inhibits growth of prostate cancer via Her-2 suppression. (PMID: 29633185) Lin X … Wang Y (Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2018) 3 58
  2. MiR-4319 Suppress the Malignancy of Triple-Negative Breast Cancer by Regulating Self-Renewal and Tumorigenesis of Stem Cells. (PMID: 30021199) Chu J … Yuan H (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018) 3 58
  3. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S … Sun J (Carcinogenesis 2012) 3 58
  4. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff LA … Hart RP (PloS one 2009) 3 58
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR4319 Gene

Sources for MIR4319 Gene

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