microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4316 Gene

Data sources for MIR4316 Gene:

Subcategory (RNA class) for MIR4316 Gene

miRNA

Aliases for MIR4316 Gene

External Ids for MIR4316 Gene

Previous GeneCards Identifiers for MIR4316 Gene

  • GC17U901500
  • GC17M075393

Summaries for MIR4316 Gene

Entrez Gene Summary for MIR4316 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4316 Gene

MIR4316 (MicroRNA 4316) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4316 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4316 Gene

Genomics for MIR4316 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR4316 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J077398 Promoter/Enhancer 1.2 Ensembl ENCODE dbSUPER 0.7 -2.8 -2750 3.4 CTCF SIN3A REST TRIM22 ZNF341 EBF1 SMC3 RBM22 RAD21 SPI1 MIR4316 HSALNG0118921 HSALNG0118922 SEPTIN9 TNRC6C
GH17J077379 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +8.7 8669 18.7 CHD2 MXD4 CEBPA NR2C1 MNT IKZF1 HES1 MBD2 ZIC2 HOMEZ SEPTIN9 SRSF2 ENSG00000267546 ENSG00000266998 ENSG00000272386 METTL23 ENSG00000287257 lnc-SRSF2-9 MIR4316 HSALNG0118921
GH17J077402 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -11.1 -11122 11.3 BCL11A SP1 NR2C1 SIN3A GABPA FOXA2 TRIM22 IRF4 KLF7 EBF1 ENSG00000266998 MIR4316 HSALNG0118922 SEPTIN9 TNRC6C
GH17J077415 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.3 -34.9 -34903 32.5 SP1 BCL11A MXD4 FEZF1 CEBPA NR2C1 MNT IKZF1 ETS1 ZFP64 TMC8 METTL23 SRSF2 RHBDF2 SEPTIN9 HSALNG0118922 LOC112268199 lnc-TMC6-12 ENSG00000200651 ENSG00000279801
GH17J077416 Enhancer 0.4 Ensembl dbSUPER 0.4 -17.2 -17247 0.2 ZBTB40 MIR4316 HSALNG0118922 SEPTIN9 TNRC6C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4316 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR4316 Gene

Latest Assembly
chr17:77,396,984-77,397,054
(GRCh38/hg38)
Size:
71 bases
Orientation:
Minus strand

Previous Assembly
chr17:75,393,066-75,393,136
(GRCh37/hg19 by Entrez Gene)
Size:
71 bases
Orientation:
Minus strand

chr17:75,393,066-75,393,136
(GRCh37/hg19 by Ensembl)
Size:
71 bases
Orientation:
Minus strand

Genomic View for MIR4316 Gene

Genes around MIR4316 on UCSC Golden Path with GeneCards custom track
MIR4316 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR4316 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4316 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4316 Gene

Proteins for MIR4316 Gene

Post-translational modifications for MIR4316 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4316 Gene

Domains & Families for MIR4316 Gene

Gene Families for MIR4316 Gene

HGNC:
genes like me logo Genes that share domains with MIR4316: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4316 Gene

Function for MIR4316 Gene

Phenotypes From GWAS Catalog for MIR4316 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4316 Gene

Localization for MIR4316 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4316 Gene

Pathways & Interactions for MIR4316 Gene

PathCards logo

SuperPathways for MIR4316 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR4316 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4316 Gene

Drugs & Compounds for MIR4316 Gene

No Compound Related Data Available

Transcripts for MIR4316 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR4316 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075C32A_9606 precursor_RNA 71 3

RefSeq: NR_036200,

Ensembl: ENST00000579394 (view in UCSC) ,

miRBase: MI0015845,

URS000075C3BE_9606 miRNA 17 2

RefSeq: NR_036200,

miRBase: MIMAT0016867,

MIR4316 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4316 Gene

No ASD Table

Relevant External Links for MIR4316 Gene

GeneLoc Exon Structure for
MIR4316

No data available for mRNA/cDNA for MIR4316 Gene

Expression for MIR4316 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR4316

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4316 Gene

Orthologs for MIR4316 Gene

Evolution for MIR4316 Gene

ENSEMBL:
Gene Tree for MIR4316 (if available)
TreeFam:
Gene Tree for MIR4316 (if available)

No data available for Orthologs for MIR4316 Gene

Paralogs for MIR4316 Gene

No data available for Paralogs for MIR4316 Gene

Variants for MIR4316 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR4316 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR4316 Gene

Variant ID Type Subtype PubMed ID
dgv3284n100 CNV gain 25217958
nsv833552 CNV loss 17160897

Additional Variant Information for MIR4316 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4316

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4316 Gene

Disorders for MIR4316 Gene

Additional Disease Information for MIR4316

No disorders were found for MIR4316 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4316 Gene

Publications for MIR4316 Gene

  1. LncRNA CALML3-AS1 promotes tumorigenesis of bladder cancer via regulating ZBTB2 by suppression of microRNA-4316. (PMID: 30177388) Wang F … Yang Y (Biochemical and biophysical research communications 2018) 3
  2. Circular RNA circMYO9B facilitates breast cancer cell proliferation and invasiveness via upregulating FOXP4 expression by sponging miR-4316. (PMID: 29702064) Wang N … Qiu X (Archives of biochemistry and biophysics 2018) 3
  3. Evaluation of miR-506 and miR-4316 expression in early and non-invasive diagnosis of colorectal cancer. (PMID: 28405738) Krawczyk P … Milanowski J (International journal of colorectal disease 2017) 3
  4. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff LA … Hart RP (PloS one 2009) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR4316 Gene

Sources for MIR4316 Gene