microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR4310 Gene

Subcategory (RNA class) for MIR4310 Gene

miRNA

Number of RNA Genes sources:

1 / 14

Aliases for MIR4310 Gene

  • MicroRNA 4310 2 3 5
  • Hsa-Mir-4310 3
  • MIMAT0016862 51
  • MI0015840 51
  • MIR4310 2

External Ids for MIR4310 Gene

Previous GeneCards Identifiers for MIR4310 Gene

  • GC15U901223
  • GC15M042158

Summaries for MIR4310 Gene

Entrez Gene Summary for MIR4310 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR4310 Gene

MIR4310 (MicroRNA 4310) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR4310 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR4310 Gene

Genomics for MIR4310 Gene

GeneHancer (GH) Regulatory Elements for MIR4310 Gene

Promoters and enhancers for MIR4310 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J041865 Enhancer 0.8 Ensembl CraniofacialAtlas 500.7 +0.2 151 1.6 RFX1 ZBTB7A ZFHX2 NR2F1 TAF15 RARA NR2F6 NR2C2 HNF4A ZNF48 MIR4310 SPTBN5 NDUFAF1 MAPKBP1 RNA5SP393 RF00001-122
GH15J041862 Enhancer 0.8 Ensembl ENCODE CraniofacialAtlas 0.7 +3.7 3716 0.9 ZIC2 ZNF189 ZNF48 NFIA ZFX FOXA1 SPTBN5 NDUFAF1 MIR4310 RNA5SP393 RF00001-122
GH15J041870 Enhancer 0.6 Ensembl ENCODE 0.7 -4.5 -4450 1.2 FOS ZIC2 NRF1 RXRA PCBP1 SPTBN5 MIR4310 LOC105370792
GH15J041859 Enhancer 0.7 Ensembl 0.4 +6.3 6250 1 CTCF CTBP1 NR2F2 RAD21 SAP130 GABPB1 NR2F1 EZH2 HOMEZ RARA MIR4310 RNA5SP393 RF00001-122 SPTBN5
GH15J041855 Enhancer 0.6 Ensembl CraniofacialAtlas 0.4 +11.0 10950 1.2 ZFHX2 ZNF189 EGR1 GLIS1 EGR2 ZNF600 SPTBN5 PLA2G4B ENSG00000174171 RF00001-122 RNA5SP393 MIR4310
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR4310 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR4310 Gene

Genomic Locations for MIR4310 Gene
chr15:41,866,495-41,866,551
(GRCh38/hg38)
Size:
57 bases
Orientation:
Minus strand
chr15:42,158,693-42,158,749
(GRCh37/hg19)
Size:
57 bases
Orientation:
Minus strand

Genomic View for MIR4310 Gene

Genes around MIR4310 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR4310 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR4310 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR4310 Gene

Proteins for MIR4310 Gene

Post-translational modifications for MIR4310 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR4310 Gene

Domains & Families for MIR4310 Gene

Gene Families for MIR4310 Gene

HGNC:
genes like me logo Genes that share domains with MIR4310: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR4310 Gene

Function for MIR4310 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR4310 Gene

Localization for MIR4310 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR4310 Gene

Pathways & Interactions for MIR4310 Gene

PathCards logo

SuperPathways for MIR4310 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR4310 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR4310 Gene

Drugs & Compounds for MIR4310 Gene

No Compound Related Data Available

Transcripts for MIR4310 Gene

mRNA/cDNA for MIR4310 Gene

2 RNACentral transcripts :
1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 miRBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR4310 Gene

No ASD Table

Relevant External Links for MIR4310 Gene

GeneLoc Exon Structure for
MIR4310

Expression for MIR4310 Gene

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR4310 Gene

Orthologs for MIR4310 Gene

Evolution for MIR4310 Gene

ENSEMBL:
Gene Tree for MIR4310 (if available)
TreeFam:
Gene Tree for MIR4310 (if available)

No data available for Orthologs for MIR4310 Gene

Paralogs for MIR4310 Gene

No data available for Paralogs for MIR4310 Gene

Variants for MIR4310 Gene

Additional dbSNP identifiers (rs#s) for MIR4310 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR4310 Gene

Variant ID Type Subtype PubMed ID
dgv2582n100 CNV gain 25217958
nsv1035998 CNV gain 25217958
nsv1038933 CNV gain 25217958
nsv1050892 CNV gain 25217958
nsv517631 CNV loss 19592680
nsv9244 CNV gain 18304495
nsv952613 CNV deletion 24416366

Additional Variant Information for MIR4310 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR4310

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR4310 Gene

Disorders for MIR4310 Gene

Additional Disease Information for MIR4310

No disorders were found for MIR4310 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR4310 Gene

Publications for MIR4310 Gene

  1. LncRNA CASC15 promotes colon cancer cell proliferation and metastasis by regulating the miR‑4310/LGR5/Wnt/β‑catenin signaling pathway. (PMID: 29956772) Jing N … Zhang Y (Molecular medicine reports 2018) 3 54
  2. Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors. (PMID: 19784364) Goff LA … Hart RP (PloS one 2009) 3 54
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54

Products for MIR4310 Gene

Sources for MIR4310 Gene