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Aliases for MIR431 Gene

Subcategory (RNA class) for MIR431 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR431 Gene

  • MicroRNA 431 2 3 5
  • Hsa-Mir-431 3
  • MiRNA431 3
  • Mir-431 3
  • MIRN431 3

External Ids for MIR431 Gene

ORGUL Members for MIR431 Gene

Previous HGNC Symbols for MIR431 Gene

  • MIRN431

Previous GeneCards Identifiers for MIR431 Gene

  • GC14P100465
  • GC14P100848
  • GC14P101347
  • GC14P101058
  • GC14P101283
  • GC14P101911
  • GC14P102220
  • GC14P102387
  • GC14P102565
  • GC14P102738

Summaries for MIR431 Gene

Entrez Gene Summary for MIR431 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR431 Gene

MIR431 (MicroRNA 431) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Parkinsons Disease Pathway and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

Additional gene information for MIR431 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR431 Gene

Genomics for MIR431 Gene

GeneHancer (GH) Regulatory Elements for MIR431 Gene

Promoters and enhancers for MIR431 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I100880 Enhancer 0.2 ENCODE 550.8 -0.2 -166 1 GC14P103221 MIR431 MIR433 GC14P103199 RTL1 MIR665 ENSG00000258399
GH14I100819 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -54.5 -54471 13.4 ELF3 PKNOX1 FOXA2 ZSCAN4 NFXL1 ZNF48 RAD21 RFX5 ZNF280A SLC30A9 ENSG00000274884 DLK1 MEG3 MIR493 MIR337 MIR431 MIR127 MIR136 MIR433 RTL1
GH14I100691 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10 -187.6 -187590 4.1 FOXA2 MLX ZNF48 ETS1 GLIS2 ZNF143 FOS SP5 REST ZNF623 DLK1 MIR493 MIR337 MIR127 MIR431 MIR433 MIR136 RTL1 LINC00523 LOC105370668
GH14I100486 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 8.8 -394.6 -394568 0.6 ARID4B SIN3A FEZF1 ZNF2 ZNF48 ZNF143 ATF7 RUNX3 JUNB MXD4 RN7SKP92 MIR337 MIR493 MIR431 MIR127 MIR136 MIR433 RTL1 GC14P103283 GC14M100431
GH14I100657 Enhancer 1.4 Ensembl ENCODE dbSUPER 9.6 -216.5 -216496 13.4 ATF1 FOXA2 ARID4B DMAP1 ZNF2 ZNF48 ZNF143 ATF7 FOS RXRA LOC105370667 DLK1 WARS WDR25 BEGAIN MEG9 MIR493 MIR337 MIR127 MIR431
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR431 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR431 Gene

Genomic Locations for MIR431 Gene
chr14:100,881,007-100,881,120
(GRCh38/hg38)
Size:
114 bases
Orientation:
Plus strand
chr14:101,347,344-101,347,457
(GRCh37/hg19)

Genomic View for MIR431 Gene

Genes around MIR431 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR431 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR431 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR431 Gene

Proteins for MIR431 Gene

Post-translational modifications for MIR431 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR431 Gene

Domains & Families for MIR431 Gene

Gene Families for MIR431 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR431: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR431 Gene

Function for MIR431 Gene

Phenotypes From GWAS Catalog for MIR431 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR431 Gene

Localization for MIR431 Gene

Gene Ontology (GO) - Cellular Components for MIR431 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR431: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR431 Gene

Pathways & Interactions for MIR431 Gene

genes like me logo Genes that share pathways with MIR431: view

Pathways by source for MIR431 Gene

2 BioSystems pathways for MIR431 Gene

Interacting Proteins for MIR431 Gene

Gene Ontology (GO) - Biological Process for MIR431 Gene

None

No data available for SIGNOR curated interactions for MIR431 Gene

Drugs & Compounds for MIR431 Gene

No Compound Related Data Available

Transcripts for MIR431 Gene

mRNA/cDNA for MIR431 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR431 Gene

No ASD Table

Relevant External Links for MIR431 Gene

GeneLoc Exon Structure for
MIR431
ECgene alternative splicing isoforms for
MIR431

Expression for MIR431 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR431 Gene

mRNA differential expression in normal tissues according to GTEx for MIR431 Gene

This gene is overexpressed in Brain - Hypothalamus (x39.2), Brain - Substantia nigra (x5.3), and Adrenal Gland (x4.6).

NURSA nuclear receptor signaling pathways regulating expression of MIR431 Gene:

MIR431
genes like me logo Genes that share expression patterns with MIR431: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR431 Gene

Orthologs for MIR431 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR431 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-431 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir431 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-431 34
  • 94 (a)
OneToOne
Species where no ortholog for MIR431 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR431 Gene

ENSEMBL:
Gene Tree for MIR431 (if available)
TreeFam:
Gene Tree for MIR431 (if available)

Paralogs for MIR431 Gene

No data available for Paralogs for MIR431 Gene

Variants for MIR431 Gene

Sequence variations from dbSNP and Humsavar for MIR431 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000267233 -- 100,880,894(+) T/A upstream_transcript_variant
rs1002522085 -- 100,880,636(+) G/A upstream_transcript_variant
rs1004495568 -- 100,880,628(+) T/G upstream_transcript_variant
rs1006137561 -- 100,881,424(+) C/T downstream_transcript_variant
rs1006170180 -- 100,881,621(+) G/C

Structural Variations from Database of Genomic Variants (DGV) for MIR431 Gene

Variant ID Type Subtype PubMed ID
nsv509549 CNV insertion 20534489
esv3635518 CNV gain 21293372

Additional Variant Information for MIR431 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR431

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR431 Gene

Disorders for MIR431 Gene

Additional Disease Information for MIR431

No disorders were found for MIR431 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR431 Gene

Publications for MIR431 Gene

  1. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 58
  2. Correlation between down-expression of miR-431 and clinicopathological significance in HCC tissues. (PMID: 25775917) Pan L … Chen G (Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2015) 3 58
  3. Inhibition of cell viability by human IFN-β is mediated by microRNA-431. (PMID: 22293894) Tanaka T … Suzuki N (International journal of oncology 2012) 3 58
  4. Differential microRNA expression in peripheral blood mononuclear cells from Graves' disease patients. (PMID: 22456620) Liu R … Wang S (The Journal of clinical endocrinology and metabolism 2012) 3 58
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58

Products for MIR431 Gene

Sources for MIR431 Gene

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