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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR4302 (MicroRNA 4302) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH12J025875 | Enhancer | 0.5 | Ensembl ENCODE | 250.7 | -1.5 | -1515 | 0.8 | CEBPB ZNF512 | MIR4302 RASSF8 RASSF8-AS1 HSALNG0089949 LMNTD1 | |
GH12J025867 | Enhancer | 0.6 | Ensembl ENCODE | 0.4 | +7.1 | 7078 | 1.6 | OSR2 MZF1 WT1 | HSALNG0089946 MIR4302 RASSF8 LMNTD1 | |
GH12J025863 | Enhancer | 0.6 | ENCODE | 0.4 | +10.7 | 10716 | 0.2 | ZEB1 CEBPB PRDM6 JUND SP7 ZFP69B ZEB2 CBX8 EP300 FOS | HSALNG0089946 MIR4302 RASSF8 LMNTD1 | |
GH12J025876 | Enhancer | 0.2 | ENCODE | 0.7 | -2.4 | -2400 | 0.2 | RASSF8 RASSF8-AS1 MIR4302 HSALNG0089949 LMNTD1 | ||
GH12J025877 | Enhancer | 0.2 | ENCODE | 0.7 | -2.6 | -2624 | 0.2 | RASSF8 RASSF8-AS1 MIR4302 HSALNG0089949 LMNTD1 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075C647_9606 | precursor_RNA | 60 | 3 |
RefSeq: NR_036188, Ensembl: ENST00000638058 (view in UCSC) , miRBase: MI0015833, |
URS000075E65D_9606 | miRNA | 18 | 2 |
RefSeq: NR_036188, miRBase: MIMAT0016855, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759886 | CNV | loss | 17122850 |
nsv1035319 | CNV | loss | 25217958 |
No disorders were found for MIR4302 Gene.